D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 111 Citations 46,352 296 World Ranking 3085 National Ranking 1760
Biology and Biochemistry D-index 114 Citations 50,749 317 World Ranking 547 National Ranking 372

Research.com Recognitions

Awards & Achievements

2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

The scientist’s investigation covers issues in Cell biology, Receptor, Sphingosine, Angiogenesis and Sphingosine-1-phosphate. His Cell biology research incorporates elements of Adherens junction assembly, S1PR1 and Sphingosine-1-phosphate receptor. His studies link Endocrinology with Receptor.

His Sphingosine research integrates issues from Extracellular, Endothelium, Protein kinase B and Lipid signaling. To a larger extent, Timothy Hla studies Cancer research with the aim of understanding Angiogenesis. The study incorporates disciplines such as GTP-binding protein regulators, Mediator, P2Y receptor and Vascular permeability in addition to Sphingosine-1-phosphate.

His most cited work include:

  • Human cyclooxygenase-2 cDNA. (1358 citations)
  • Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (1290 citations)
  • Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer (1066 citations)

What are the main themes of his work throughout his whole career to date?

Timothy Hla focuses on Cell biology, Receptor, Sphingosine, Sphingosine-1-phosphate and Cancer research. His research in Cell biology intersects with topics in S1PR1, Angiogenesis and Sphingosine-1-phosphate receptor. His biological study spans a wide range of topics, including Endocrinology and Endothelium.

Timothy Hla has researched Sphingosine in several fields, including Endothelial stem cell, Sphingolipid, Lipid signaling and Immunology. His work carried out in the field of Sphingosine-1-phosphate brings together such families of science as Cell migration, Mediator and Immune system. His studies deal with areas such as Carcinogenesis, Inflammation, Apoptosis and Peroxisome proliferator-activated receptor as well as Cancer research.

He most often published in these fields:

  • Cell biology (52.94%)
  • Receptor (35.59%)
  • Sphingosine (37.06%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (52.94%)
  • Sphingosine (37.06%)
  • Receptor (35.59%)

In recent papers he was focusing on the following fields of study:

Cell biology, Sphingosine, Receptor, Sphingosine-1-phosphate and S1PR1 are his primary areas of study. Timothy Hla specializes in Cell biology, namely G protein-coupled receptor. In his work, Ceramide synthase 2 and Cell cycle is strongly intertwined with Kinase, which is a subfield of Sphingosine.

His work deals with themes such as APOM, Endocrinology, Signal transduction and Cancer research, which intersect with Receptor. His Sphingosine-1-phosphate research is multidisciplinary, relying on both Angiogenesis, Mediator and Immune system. His study in S1PR1 is interdisciplinary in nature, drawing from both Barrier function, S1PR2, S1PR3 and Tight junction.

Between 2014 and 2021, his most popular works were:

  • Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy (275 citations)
  • HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation (168 citations)
  • Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. (143 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His scientific interests lie mostly in Cell biology, Sphingosine, Receptor, Endothelium and Sphingosine-1-phosphate. The Cell biology study combines topics in areas such as Lipid signaling and Immunology. His Sphingosine research is multidisciplinary, incorporating elements of Endothelial stem cell, Sphingolipid, Barrier function, Lymphatic system and S1PR1.

Timothy Hla interconnects APOM and Endocrinology, Vascular permeability in the investigation of issues within Receptor. His studies examine the connections between Endothelium and genetics, as well as such issues in Sphingosine-1-phosphate receptor, with regards to Phenotype, Agonist, Cholestasis, Liver regeneration and Cancer research. His study focuses on the intersection of Sphingosine-1-phosphate and fields such as Immune system with connections in the field of Bone marrow, Lymphocyte, Lymphopoiesis and Haematopoiesis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Daniel L. Simmons;Regina M. Botting;Timothy Hla.
Pharmacological Reviews (2004)

2105 Citations

Human cyclooxygenase-2 cDNA.

Timothy Hla;Karen Neilson.
Proceedings of the National Academy of Sciences of the United States of America (1992)

1974 Citations

Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer

Hajime Sano;Yutaka Kawahito;Ronald L. Wilder;Akira Hashiramoto.
Cancer Research (1995)

1606 Citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Yujing Liu;Ryuichi Wada;Tadashi Yamashita;Yide Mi.
Journal of Clinical Investigation (2000)

1329 Citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

Menq-Jer Lee;Shobha Thangada;Kevin P Claffey;Nicolas Ancellin.
Cell (1999)

1143 Citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

Menq Jer Lee;James R. Van Brocklyn;Shobha Thangada;Catherine H. Liu.
Science (1998)

1123 Citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

Catherine H. Liu;Sung-Hee Chang;Kirsi Narko;Ovidiu C. Trifan.
Journal of Biological Chemistry (2001)

1090 Citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

Leslie J. Crofford;Ronald L. Wilder;Ari P. Ristimaki;Hajime Sano.
Journal of Clinical Investigation (1994)

919 Citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

D Goldgaber;H W Harris;T Hla;T Maciag.
Proceedings of the National Academy of Sciences of the United States of America (1989)

746 Citations

Structure of the human cyclo-oxygenase-2 gene

S B Appleby;A Ristimäki;K Neilson;K Narko.
Biochemical Journal (1994)

737 Citations

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