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Biology and Biochemistry

D-Index
122
Citations
56092
World Ranking
582
National Ranking
372

Medicine

D-Index
122
Citations
56023
World Ranking
3472
National Ranking
1908

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Timothy Hla is affiliated with Harvard University in the United States and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Their research focuses primarily on Molecular Biology, Cell Biology, Immunology, Genetics, and Physiology.

The core scientific work of Timothy Hla includes studies in sphingolipid metabolism and signaling, notably within the context of vascular biology and immunological regulation. Other notable research topics involve caveolin-1 and cellular processes, zebrafish biomedical research applications, retinal diseases and treatments, phagocytosis and immune regulation, lipid metabolism and disorders, and connective tissue disorders.

Frequent publication venues for Timothy Hla include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Arteriosclerosis Thrombosis and Vascular Biology
  • JCI Insight
  • Developmental Cell

Their publication record highlights several recent papers, such as:

  • Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke, 2020, Circulation Research
  • Lysophospholipid Mediators in Health and Disease, 2021, Annual Review of Pathology Mechanisms of Disease
  • Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy, 2020, Proceedings of the National Academy of Sciences
  • S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling, 2020, JCI Insight
  • Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases, 2022, Nature Reviews Rheumatology

Timothy Hla has collaborated frequently with colleagues including Andrew Kuo, Andréane Cartier, Colin Niaudet, B. Jung, and Steven Swendeman.

In recognition of their scientific contributions, Timothy Hla was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2016.

Best Publications

  • Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

    Daniel L. Simmons;Regina M. Botting;Timothy Hla

  • Human cyclooxygenase-2 cDNA.

    Timothy Hla;Karen Neilson

  • Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer

    Hajime Sano;Yutaka Kawahito;Ronald L. Wilder;Akira Hashiramoto

  • Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

    Yujing Liu;Ryuichi Wada;Tadashi Yamashita;Yide Mi

  • Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

    Menq Jer Lee;James R. Van Brocklyn;James R. Van Brocklyn;James R. Van Brocklyn;Shobha Thangada;Shobha Thangada;Shobha Thangada;Catherine H. Liu;Catherine H. Liu;Catherine H. Liu

  • Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

    Menq-Jer Lee;Shobha Thangada;Kevin P Claffey;Nicolas Ancellin

  • Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

    Catherine H. Liu;Sung-Hee Chang;Kirsi Narko;Ovidiu C. Trifan

  • Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

    Leslie J. Crofford;Ronald L. Wilder;Ari P. Ristimaki;Hajime Sano

  • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

    D Goldgaber;H W Harris;T Hla;T Maciag

  • Structure of the human cyclo-oxygenase-2 gene

    S B Appleby;A Ristimäki;K Neilson;K Narko

  • Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

    Pazit Ben-Av;Leslie J. Crofford;Ronald L. Wilder;Timothy Hla

  • The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses.

    Robert B. Clark;David Bishop-Bailey;Tatiana Estrada-Hernandez;Timothy Hla

  • Lysophospholipids--receptor revelations.

    Timothy Hla;Menq-Jer Lee;Nicolas Ancellin;Ji H. Paik

  • FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

    Volker Brinkmann;Jason G. Cyster;Timothy Hla

  • Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2.

    David Bishop-Bailey;Timothy Hla

  • Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.

    Christina Christoffersen;Hideru Obinata;Sunil B. Kumaraswamy;Sylvain Galvani

  • Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

    O Laneuville;D K Breuer;D L Dewitt;T Hla

  • Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

    A Ristimäki;S Garfinkel;J Wessendorf;T Maciag

  • International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

    Jerold Chun;Edward J. Goetzl;Timothy Hla;Yasuyuki Igarashi

  • An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

    T Hla;T Maciag

Frequent Co-Authors

Richard L. Proia
Richard L. Proia National Institutes of Health
Jihye Paik
Jihye Paik Cornell University
Thomas Maciag
Thomas Maciag Maine Medical Center
Kevin P. Claffey
Kevin P. Claffey University of Connecticut Health Center
Ari Ristimäki
Ari Ristimäki University of Helsinki
Andrew J. Dannenberg
Andrew J. Dannenberg Cornell University
Todd Evans
Todd Evans Cornell University
Christer Betsholtz
Christer Betsholtz Uppsala University
Kotha Subbaramaiah
Kotha Subbaramaiah Cornell University
Frederick R. Maxfield
Frederick R. Maxfield Cornell University

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