2016 - Fellow of the American Association for the Advancement of Science (AAAS)
The scientist’s investigation covers issues in Cell biology, Receptor, Sphingosine, Angiogenesis and Sphingosine-1-phosphate. His Cell biology research incorporates elements of Adherens junction assembly, S1PR1 and Sphingosine-1-phosphate receptor. His studies link Endocrinology with Receptor.
His Sphingosine research integrates issues from Extracellular, Endothelium, Protein kinase B and Lipid signaling. To a larger extent, Timothy Hla studies Cancer research with the aim of understanding Angiogenesis. The study incorporates disciplines such as GTP-binding protein regulators, Mediator, P2Y receptor and Vascular permeability in addition to Sphingosine-1-phosphate.
Timothy Hla focuses on Cell biology, Receptor, Sphingosine, Sphingosine-1-phosphate and Cancer research. His research in Cell biology intersects with topics in S1PR1, Angiogenesis and Sphingosine-1-phosphate receptor. His biological study spans a wide range of topics, including Endocrinology and Endothelium.
Timothy Hla has researched Sphingosine in several fields, including Endothelial stem cell, Sphingolipid, Lipid signaling and Immunology. His work carried out in the field of Sphingosine-1-phosphate brings together such families of science as Cell migration, Mediator and Immune system. His studies deal with areas such as Carcinogenesis, Inflammation, Apoptosis and Peroxisome proliferator-activated receptor as well as Cancer research.
Cell biology, Sphingosine, Receptor, Sphingosine-1-phosphate and S1PR1 are his primary areas of study. Timothy Hla specializes in Cell biology, namely G protein-coupled receptor. In his work, Ceramide synthase 2 and Cell cycle is strongly intertwined with Kinase, which is a subfield of Sphingosine.
His work deals with themes such as APOM, Endocrinology, Signal transduction and Cancer research, which intersect with Receptor. His Sphingosine-1-phosphate research is multidisciplinary, relying on both Angiogenesis, Mediator and Immune system. His study in S1PR1 is interdisciplinary in nature, drawing from both Barrier function, S1PR2, S1PR3 and Tight junction.
His scientific interests lie mostly in Cell biology, Sphingosine, Receptor, Endothelium and Sphingosine-1-phosphate. The Cell biology study combines topics in areas such as Lipid signaling and Immunology. His Sphingosine research is multidisciplinary, incorporating elements of Endothelial stem cell, Sphingolipid, Barrier function, Lymphatic system and S1PR1.
Timothy Hla interconnects APOM and Endocrinology, Vascular permeability in the investigation of issues within Receptor. His studies examine the connections between Endothelium and genetics, as well as such issues in Sphingosine-1-phosphate receptor, with regards to Phenotype, Agonist, Cholestasis, Liver regeneration and Cancer research. His study focuses on the intersection of Sphingosine-1-phosphate and fields such as Immune system with connections in the field of Bone marrow, Lymphocyte, Lymphopoiesis and Haematopoiesis.
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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Daniel L. Simmons;Regina M. Botting;Timothy Hla.
Pharmacological Reviews (2004)
Human cyclooxygenase-2 cDNA.
Timothy Hla;Karen Neilson.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer
Hajime Sano;Yutaka Kawahito;Ronald L. Wilder;Akira Hashiramoto.
Cancer Research (1995)
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
Yujing Liu;Ryuichi Wada;Tadashi Yamashita;Yide Mi.
Journal of Clinical Investigation (2000)
Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate
Menq-Jer Lee;Shobha Thangada;Kevin P Claffey;Nicolas Ancellin.
Cell (1999)
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Menq Jer Lee;James R. Van Brocklyn;Shobha Thangada;Catherine H. Liu.
Science (1998)
Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice
Catherine H. Liu;Sung-Hee Chang;Kirsi Narko;Ovidiu C. Trifan.
Journal of Biological Chemistry (2001)
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
Leslie J. Crofford;Ronald L. Wilder;Ari P. Ristimaki;Hajime Sano.
Journal of Clinical Investigation (1994)
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
D Goldgaber;H W Harris;T Hla;T Maciag.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Structure of the human cyclo-oxygenase-2 gene
S B Appleby;A Ristimäki;K Neilson;K Narko.
Biochemical Journal (1994)
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