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Biology and Biochemistry

D-Index
65
Citations
12910
World Ranking
9303
National Ranking
243

Overview

Stuart M. Pitson is affiliated with the University of South Australia in Australia. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a total of 74 and 52 publications respectively. Within these broad areas, they have contributed extensively to subfields including Molecular Biology, Hematology, Cell Biology, Immunology, and Oncology.

Their work encompasses several specific research topics such as:

  • Sphingolipid Metabolism and Signaling
  • Acute Myeloid Leukemia Research
  • Phagocytosis and Immune Regulation
  • CAR-T cell therapy research
  • Erythrocyte Function and Pathophysiology
  • Multiple Myeloma Research and Treatments
  • Ubiquitin and proteasome pathways

Recent papers authored or co-authored by Stuart M. Pitson highlight diverse areas of investigation. These include:

  • "ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism," 2020, Nature Cell Biology
  • "GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma," 2022, Journal for ImmunoTherapy of Cancer
  • "Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion," 2021, Current Biology
  • "Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy," 2020, Clinical & Translational Immunology
  • "Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia," 2023, Cancer Cell

Stuart M. Pitson frequently publishes in the venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • EMBO Reports
  • Nature Cell Biology
  • Clinical & Translational Immunology

Collaboration is an important aspect of their research efforts. Frequent co-authors include Melinda N. Tea, Jason A. Powell, Lisa M. Ebert, Briony L. Gliddon, and Melissa R. Pitman, with multiple joint publications reflecting ongoing cooperative work.

Best Publications

  • Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation

    Stuart M. Pitson;Paul A.B. Moretti;Julia R. Zebol;Helen E. Lynn

  • An oncogenic role of sphingosine kinase

    Pu Xia;Jennifer R. Gamble;Lijun Wang;Stuart M. Pitson

  • Correction: Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

    Simone M. Schoenwaelder;Roxane Darbousset;Susan L. Cranmer;Hayley S. Ramshaw

  • Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

    Pu Xia;Lijun Wang;Paul A. B. Moretti;Nathaniel Albanese

  • Regulation of sphingosine kinase and sphingolipid signaling

    Stuart M. Pitson;Stuart M. Pitson

  • The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity.

    Valentina Poltavets;Marina Kochetkova;Stuart M. Pitson;Stuart M. Pitson;Michael S. Samuel;Michael S. Samuel

  • Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

    Stuart M. Pitson;Pu Xia;Tamara M. Leclercq;Paul A.B. Moretti

  • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

    Francesca Tonelli;Keng Gat Lim;Carolyn Loveridge;Jaclyn Long

  • Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.

    Stuart M. Pitson;Paul A.B. Moretti;Julia R. Zebol;Pu Xia

  • Noncellulolytic fungal β-glucanases: Their physiology and regulation

    S.M. Pitson;R.J. Seviour;B.M. McDougall

  • Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells.

    Alice Pebay;Raymond C B Wong;Stuart M Pitson;Ernst Jurgen Wolvetang

  • Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.

    Stuart M. Pitson;Richard J. D'andrea;Lucianne Vandeleur;Paul A. B. Moretti

  • An oncogenic role for sphingosine kinase 2.

    Heidi A. Neubauer;Heidi A. Neubauer;Duyen H. Pham;Duyen H. Pham;Julia R. Zebol;Paul A.B. Moretti

  • Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

    Olga A. Sukocheva;Lijun Wang;Nathaniel Albanese;Stuart M. Pitson

  • Roles, regulation and inhibitors of sphingosine kinase 2.

    Heidi A. Neubauer;Heidi A. Neubauer;Stuart M. Pitson;Stuart M. Pitson;Stuart M. Pitson

  • Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

    Kate E. Jarman;Kate E. Jarman;Paul A.B. Moretti;Julia R. Zebol;Stuart M. Pitson;Stuart M. Pitson

  • Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase.

    Steffen Sebastian Bolz;Lukas Vogel;Daniel Sollinger;Roland Derwand

  • The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function.

    Binks W. Wattenberg;Stuart M. Pitson;Daniel M. Raben

  • Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.

    Julius G. Juarez;Nadia Harun;Marilyn Thien;Robert Welschinger

  • Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

    Johnatan Ceccom;Najat Loukh;Valérie Lauwers-Cances;Christian Touriol

Frequent Co-Authors

Mathew A. Vadas
Mathew A. Vadas University of Sydney
Angel F. Lopez
Angel F. Lopez University of South Australia
Jennifer R. Gamble
Jennifer R. Gamble University of Sydney
Robert J. Seviour
Robert J. Seviour La Trobe University
Andrew I. Webb
Andrew I. Webb Walter and Eliza Hall Institute of Medical Research
Gerrit Beldman
Gerrit Beldman Wageningen University & Research
Vinay Tergaonkar
Vinay Tergaonkar Agency for Science, Technology and Research
Sandra Hodge
Sandra Hodge University of Adelaide
Susan Pyne
Susan Pyne University of Strathclyde
Nigel J. Pyne
Nigel J. Pyne University of Strathclyde

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