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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
23213
World Ranking
2880
National Ranking
65

Medicine

D-Index
87
Citations
23260
World Ranking
13785
National Ranking
456

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Angel F. Lopez is affiliated with the University of South Australia and conducts research primarily in the fields of Medicine and Immunology and Microbiology. Their work spans several subfields, including Immunology, Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, and Hematology.

The scientist's research addresses multiple topics, notably Immune Cell Function and Interaction, Asthma and Respiratory Diseases, Acute Myeloid Leukemia Research, T-cell and B-cell Immunology, Myeloproliferative Neoplasms: Diagnosis and Treatment, Malaria Research and Control, and HIV Research and Treatment.

Lopez has contributed to numerous publications, often collaborating with recurring coauthors including Denis Tvorogov, Timothy R. Hercus, Danièl Thomas, Michael W. Parker, and Winnie L. Kan. These collaborations have resulted in a consistent body of work across several leading venues.

  • Zenodo (CERN European Organization for Nuclear Research)
  • Blood
  • Journal of Allergy and Clinical Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cell Biology

Some of the recent papers authored by Lopez include:

  • "TLR7 gain-of-function genetic variation causes human lupus," 2022, Nature
  • "Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers," 2021, Science Translational Medicine
  • "ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism," 2020, Nature Cell Biology
  • "Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia," 2021, Nature Communications
  • "41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo," 2020, Journal for ImmunoTherapy of Cancer

The research contributions of Lopez focus heavily on immune mechanisms, cancer biology, and therapeutic strategies within hematology and oncology contexts. Their work on TLR7 genetic variation and lupus adds to understanding autoimmune diseases, while studies on leukemia and CAR T cell therapies contribute to advancements in cancer immunotherapy. The exploration of drug repurposing further showcases an interest in translational approaches to medical research.

Best Publications

  • Recombinant human interleukin 5 is a selective activator of human eosinophil function.

    Angel F. Lopez;Colin J. Sanderson;Jennifer R. Gamble;Hugh D. Campbell

  • Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

    A F Lopez;D J Williamson;J R Gamble;C G Begley

  • Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

    Liqing Jin;Erwin M. Lee;Hayley S. Ramshaw;Samantha J. Busfield

  • Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor.

    Metcalf D;Begley Cg;Johnson Gr;Nicola Na

  • Correction: Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

    Simone M. Schoenwaelder;Roxane Darbousset;Susan L. Cranmer;Hayley S. Ramshaw

  • Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro

    Joanna Murray;Joanna Murray;Joanna Murray;Jeffrey A.J. Barbara;Jeffrey A.J. Barbara;Jeffrey A.J. Barbara;Sarah A. Dunkley;Sarah A. Dunkley;Sarah A. Dunkley;Angel F. Lopez;Angel F. Lopez;Angel F. Lopez

  • Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice.

    D Metcalf;CG Begley;GR Johnson;NA Nicola

  • Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors.

    CG Begley;CG Begley;AF Lopez;AF Lopez;NA Nicola;NA Nicola;DJ Warren;DJ Warren

  • The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

    Timothy R Hercus;Daniel Thomas;Mark Andrew Guthridge;Paul G Ekert

  • The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

    Guido Hansen;Timothy R Hercus;Barbara J McClure;Frank C Stomski

  • Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia

    Xiaoyan Jiang;Angel Lopez;Tessa Holyoake;Allen Eaves

  • Purification and properties of bacterially synthesized human granulocyte-macrophage colony stimulating factor

    AW Burgess;CG Begley;GR Johnson;AF Lopez

  • The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors

    Christopher J. Bagley;Joanna M. Woodcock;Frank C. Stomski;Angel F. Lopez

  • Mechanism of Activation of the GM-CSF, IL-3, and IL-5 Family of Receptors

    Mark A. Guthridge;Frank C. Stomski;Daniel Thomas;Joanna M. Woodcock

  • Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors.

    A F Lopez;N A Nicola;A W Burgess;D Metcalf

  • The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling

    Sophie E. Broughton;Urmi Dhagat;Timothy R. Hercus;Tracy L. Nero

  • Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.

    A. F. Lopez;L. B. To;Yu-Chung Yang;J. R. Gamble

  • The Dimeric Versus Monomeric Status of 14-3-3ζ Is Controlled by Phosphorylation of Ser58 at the Dimer Interface

    Joanna M. Woodcock;Jane Murphy;Frank C. Stomski;Michael C. Berndt

  • Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state.

    Yat-Yuen Lim;Josephine A. Wright;Josephine A. Wright;Joanne L. Attema;Joanne L. Attema;Philip A. Gregory;Philip A. Gregory

  • Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

    J A Barbara;W B Smith;J R Gamble;X Van Ostade

Frequent Co-Authors

Michael W. Parker
Michael W. Parker University of Melbourne
Mathew A. Vadas
Mathew A. Vadas University of Sydney
Timothy P. Hughes
Timothy P. Hughes South Australian Health and Medical Research Institute
Paul G Ekert
Paul G Ekert University of New South Wales
Stuart M. Pitson
Stuart M. Pitson University of South Australia
Vinay Tergaonkar
Vinay Tergaonkar Agency for Science, Technology and Research
Jennifer R. Gamble
Jennifer R. Gamble University of Sydney
Gregory J. Goodall
Gregory J. Goodall University of Adelaide
Michael C. Berndt
Michael C. Berndt Curtin University
Nicos A. Nicola
Nicos A. Nicola Walter and Eliza Hall Institute of Medical Research

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