His scientific interests lie mostly in Immunology, Cell biology, Cytokine, Immune system and Inflammation. He regularly links together related areas like Chemotaxis in his Immunology studies. The Cell biology study combines topics in areas such as Cell, Biochemistry and Endothelium.
His Cytokine research is multidisciplinary, incorporating perspectives in Receptor, Apoptosis and Downregulation and upregulation. His Immune system research is multidisciplinary, incorporating elements of Homeostasis, Sepsis and Effector. His work on Proinflammatory cytokine as part of general Inflammation research is frequently linked to Poison control, thereby connecting diverse disciplines of science.
Leo Koenderman focuses on Immunology, Cell biology, Internal medicine, Inflammation and Eosinophil. His Cell biology course of study focuses on Biochemistry and Platelet-activating factor. His Internal medicine research incorporates elements of Gastroenterology and Endocrinology.
Leo Koenderman interconnects Tumor necrosis factor alpha and Pathology in the investigation of issues within Inflammation. His Eosinophil research integrates issues from Eosinophilia, Chemotaxis and Interleukin 5. He focuses mostly in the field of Signal transduction, narrowing it down to topics relating to Receptor and, in certain cases, Molecular biology.
Leo Koenderman spends much of his time researching Immunology, Immune system, Inflammation, Flow cytometry and Innate immune system. His research integrates issues of Phenotype and Staphylococcus aureus in his study of Immunology. His work deals with themes such as Inflammatory cascade, Recurrent infections and Severe trauma, which intersect with Immune system.
His Inflammation research incorporates elements of Tumor necrosis factor alpha, Endocrinology, Hypersegmented neutrophil, Apoptosis and Monocyte. His Innate immune system research is multidisciplinary, relying on both Systemic-onset juvenile idiopathic arthritis, Arthritis, Interleukin, Systemic inflammation and Cohort. His Nucleus study introduces a deeper knowledge of Cell biology.
His primary areas of investigation include Immunology, Immune system, Inflammation, Innate immune system and Flow cytometry. In the subject of general Immunology, his work in Interleukin 5 is often linked to Granulomatosis with polyangiitis, thereby combining diverse domains of study. His Immune system study integrates concerns from other disciplines, such as Inflammatory cascade, Recurrent infections and Immunosuppression.
His Inflammation research is multidisciplinary, incorporating perspectives in Phenotype, Blood drawing, Ex vivo and Hypersegmented neutrophil. His Innate immune system research is multidisciplinary, incorporating elements of Anakinra, Systemic inflammation, Bone marrow and CD64. His Flow cytometry research incorporates themes from Gating, Computational biology and Dimensionality reduction.
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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
Pascale F Dijkers;Rene H Medema;Jan-Willem J Lammers;Leo Koenderman.
Current Biology (2000)
In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.
Janesh Pillay;Ineke den Braber;Nienke Vrisekoop;Lydia M. Kwast.
Blood (2010)
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
Janesh Pillay;Vera M. Kamp;Els van Hoffen;Tjaakje Visser.
Journal of Clinical Investigation (2012)
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
P.F. Dijkers;R.H. Medema;C. Pals;L. Banerji.
Molecular and Cellular Biology (2000)
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
E. Caldenhoven;J. Liden;S. Wissink;A. Van de Stolpe.
Molecular Endocrinology (1995)
The systemic immune response to trauma: an overview of pathophysiology and treatment.
Janet M Lord;Mark J Midwinter;Yen-Fu Chen;Yen-Fu Chen;Antonio Belli.
The Lancet (2014)
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B–enhanced cell survival through maintenance of mitochondrial integrity
Pascale F. Dijkers;Kim U. Birkenkamp;Eric W.-F. Lam;N. Shaun B. Thomas.
Journal of Cell Biology (2002)
STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription
Eric Caldenhoven;Thamar B. van Dijk;Roberto Solari;John Armstrong.
Journal of Biological Chemistry (1996)
12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.
A. Van De Stolpe;E. Caldenhoven;B. G. Stade;L. Koenderman.
Journal of Biological Chemistry (1994)
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.
Janesh Pillay;Tamar Tak;Vera M. Kamp;Leo Koenderman.
Cellular and Molecular Life Sciences (2013)
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