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Immunology

D-Index
60
Citations
13500
World Ranking
3323
National Ranking
128

Overview

Jaap Jan Zwaginga is affiliated with Leiden University Medical Center in the Netherlands. Their research spans primarily the field of Medicine, with a substantive focus on Hematology, Immunology, and Genetics. Additional subfields of study include Biochemistry and Oncology.

Their work covers several specialized topics within these disciplines, notably:

  • Blood groups and transfusion
  • Platelet Disorders and Treatments
  • Blood transfusion and management
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Hemoglobinopathies and Related Disorders
  • Hematopoietic Stem Cell Transplantation

Zwaginga has published research in a variety of journals, with frequent contributions to:

  • Vox Sanguinis
  • Cytotherapy
  • Transfusion
  • Frontiers in Immunology
  • British Journal of Haematology

Recent papers include:

  • "Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes," 2020, published in The Lancet Diabetes & Endocrinology
  • "What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings," 2020, published in Cytotherapy
  • "Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID," 2020, published in Molecular Therapy - Methods & Clinical Development
  • "Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials," 2023, published in Clinical Infectious Diseases
  • "HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study," 2020, published in Frontiers in Immunology

Frequent co-authors in Zwaginga's research include:

  • Masja de Haas
  • Martin R. Schipperus
  • Johanna G. van der Bom
  • C. Ellen van der Schoot
  • Leendert Porcelijn

Best Publications

  • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

    Marjolijn Duijvestein;Anne Christine W Vos;Helene Roelofs;Manon E Wildenberg

  • Adipose Tissue-Derived Multipotent Stromal Cells Have a Higher Immunomodulatory Capacity Than Their Bone Marrow-Derived Counterparts

    Sara M. Melief;Jaap Jan Zwaginga;Willem E. Fibbe;Helene Roelofs

  • New gene functions in megakaryopoiesis and platelet formation

    Christian Gieger;Aparna Radhakrishnan;Ana Cvejic;Weihong Tang

  • Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial.

    Jan van Ramshorst;Jeroen J. Bax;Saskia L. M. A. Beeres;Petra Dibbets-Schneider

  • Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases.

    Janine M. van Gils;Jaap Jan Zwaginga;Jaap Jan Zwaginga;Peter L. Hordijk

  • IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC.

    Martine A. Boks;Judith R. Kager-Groenland;Michiel S.P. Haasjes;Jaap Jan Zwaginga;Jaap Jan Zwaginga

  • Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE trial

    Alexander Hirsch;Robin Nijveldt;Pieter A. van der Vleuten;Jan G.P. Tijssen

  • The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential

    Suzanne M. Watt;Suzanne M. Watt;Francesca Gullo;Francesca Gullo;Mark van der Garde;Mark van der Garde;Mark van der Garde;Daniel Markeson;Daniel Markeson;Daniel Markeson

  • VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration

    Sandra van Wetering;Nadia van den Berk;Jaap D. van Buul;Frederik P. J. Mul

  • Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid‐refractory, grade III–IV acute graft‐versus‐host disease

    Lynne M. Ball;Maria E. Bernardo;Helene Roelofs;Maarten J. D. van Tol

  • Platelet-dependent primary hemostasis promotes selectin- and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions

    P. H. M. Kuijper;H. I. Gallardo Torres;J. A. M. Van Der Linden;J.-W. J. Lammers

  • Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of β1 and β2 integrins

    Paula A. da Costa Martins;Janine M. van Gils;Anita Mol;Peter L. Hordijk

  • An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura

    Adrian Newland;Marie T. Caulier;Mies Kappers-Klunne;Martin R. Schipperus

  • Clinical effectiveness of leucoreduced, pooled donor platelet concentrates, stored in plasma or additive solution with and without pathogen reduction

    Jean-Louis Henry Kerkhoffs;Wim L.J. van Putten;Viera M.J. Novotny;Peter A. W. Te Boekhorst

  • A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: monocytes and myocardial infarction.

    Anja M. van der Laan;Alexander Hirsch;Lourens F.H.J. Robbers;Robin Nijveldt

  • Platelet and Fibrin Deposition at the Damaged Vessel Wall: Cooperative Substrates for Neutrophil Adhesion Under Flow Conditions

    P.H.M. Kuijper;H.I. Gallardo Torres;J.W.J. Lammers;J.J. Sixma

  • Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption

    Kasper M. A. Rouschop;Joris J.T.H. Roelofs;Nike Claessen;Paula da Costa Martins

  • P-Selectin Glycoprotein Ligand-1 Is Expressed on Endothelial Cells and Mediates Monocyte Adhesion to Activated Endothelium

    Paula Da Costa Martins;Juan Jesús García-Vallejo;Johannes V. Van Thienen;Mar Fernandez-Borja

  • Red-blood-cell alloimmunization and number of red-blood-cell transfusions

    S. Zalpuri;J. J. Zwaginga;S. le Cessie;J. Elshuis

  • Platelet-Monocyte Complexes Support Monocyte Adhesion to Endothelium by Enhancing Secondary Tethering and Cluster Formation

    P. da Costa Martins;N. van den Berk;Laurien H. Ulfman;L. Koenderman

  • The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization.

    Anja ten Brinke;Miriam L. Karsten;Miranda C. Dieker;Jaap Jan Zwaginga

Frequent Co-Authors

Willem E. Fibbe
Willem E. Fibbe Leiden University Medical Center
Martin J. Schalij
Martin J. Schalij Leiden University Medical Center
Anneke Brand
Anneke Brand Leiden University Medical Center
Leo Koenderman
Leo Koenderman Utrecht University
Jeroen J. Bax
Jeroen J. Bax Leiden University Medical Center
Albert de Roos
Albert de Roos Leiden University Medical Center
Arjan C. Lankester
Arjan C. Lankester Leiden University Medical Center
Peter L. Hordijk
Peter L. Hordijk University of Amsterdam
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge

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