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Biology and Biochemistry

D-Index
60
Citations
15120
World Ranking
11830
National Ranking
5088

Overview

Victor S. Goldmacher is affiliated with ImmunoGen in the United States and specializes in research intersecting medicine, biochemistry, molecular biology, and oncology. Their recent work emphasizes the development of antibody-based therapies and cancer treatment strategies.

The researcher's primary areas of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields encompass:

  • Radiology, Nuclear Medicine and Imaging
  • Oncology
  • Molecular Biology
  • Immunology

Main topics addressed in their research are:

  • Monoclonal and Polyclonal Antibodies Research
  • Glycosylation and Glycoproteins Research
  • HER2/EGFR in Cancer Research
  • Toxin Mechanisms and Immunotoxins
  • Cancer Treatment and Pharmacology

Victor S. Goldmacher has published several scientific papers recently, focusing on bispecific antibodies and antibody-drug conjugates for targeted tumor therapy. Notable publications include:

  • "Beyond ADCs: harnessing bispecific antibodies to directly induce apoptosis for targeted tumor eradication," 2024, Antibody Therapeutics
  • "A bispecific anti-MUC16/anti-death receptor 5 antibody achieves effective and tumor-selective death receptor 5-mediated tumor regression," 2025, Scientific Reports
  • "A bispecific antibody overcomes limitations of prior strategies to achieve effective and tumor-selective Death Receptor 5 (DR5) clustering," 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • "Antibody-drug conjugates in cancer and beyond: progress, promise, and perspectives," 2025, Antibody Therapeutics

Frequent collaborators in their research include:

  • Iosif M. Gershteyn
  • Yelena Kovtun
  • Ravi Chari

The most common venues for their publications are:

  • Antibody Therapeutics
  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Cytotoxic agents comprising maytansinoids and their therapeutic use

    Ravi J. Chari;Victor S. Goldmacher;John M. Lambert;Walter A. Blattler

  • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

    Hans K. Erickson;Peter U. Park;Wayne C. Widdison;Yelena V. Kovtun

  • Immunoconjugates containing novel maytansinoids: promising anticancer drugs.

    Ravi V. J. Chari;Bridget A. Martell;Jonathan L. Gross;Sherrilyn B. Cook

  • Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen.

    Yelena V. Kovtun;Charlene A. Audette;Yumei Ye;Hongsheng Xie

  • A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.

    Anna Skaletskaya;Laura M. Bartle;Thomas Chittenden;A. Louise McCormick

  • A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

    Victor S. Goldmacher;Laura M. Bartle;Anna Skaletskaya;Cheryl A. Dionne

  • Semisynthetic maytansine analogues for the targeted treatment of cancer.

    Wayne C Widdison;Sharon D Wilhelm;Emily E Cavanagh;Kathleen R Whiteman

  • Humanization of murine monoclonal antibodies through variable domain resurfacing

    Michael A. Roguska;Jan T. Pedersen;Christine A. Keddy;Andrew H. Henry

  • SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.

    Jutta Deckert;Marie-Cécile Wetzel;Laura M. Bartle;Anna Skaletskaya

  • ERADICATION OF LARGE COLON TUMOR XENOGRAFTS BY TARGETED DELIVERY OF MAYTANSINOIDS

    C. Liu;B. M. Tadayoni;L. A. Bourret;K. M. Mattocks

  • Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

    Yelena V. Kovtun;Charlene A. Audette;Michele F. Mayo;Gregory E. Jones

  • The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

    Helena L A Vieira;Anne Sophie Belzacq;Delphine Haouzi;Francesca Bernassola

  • Cell killing by antibody-drug conjugates.

    Yelena V. Kovtun;Victor S. Goldmacher

  • Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

    Damien Arnoult;Laura M. Bartle;Anna Skaletskaya;Delphine Poncet

  • Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

    J M Lambert;P D Senter;A Yau-Young;W A Blättler

  • Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion

    ML Grossbard;AS Freedman;J Ritz;F Coral

  • Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms.

    M L Grossbard;J M Lambert;V S Goldmacher;N L Spector

  • IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

    Olga Ab;Kathleen R. Whiteman;Laura M. Bartle;Xiuxia Sun

  • Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates.

    Robert Y. Zhao;Sharon D. Wilhelm;Charlene Audette;Gregory Jones

  • Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates

    Iwao Ojima;Xudong Geng;Xinyuan Wu;Chuanxing Qu

Frequent Co-Authors

John M. Lambert
John M. Lambert ImmunoGen (United States)
Jagesh V. Shah
Jagesh V. Shah Harvard University
Guido Kroemer
Guido Kroemer Université Paris Cité
Stuart F. Schlossman
Stuart F. Schlossman Harvard University
Nancy Kedersha
Nancy Kedersha Harvard University
Pierfrancesco Tassone
Pierfrancesco Tassone Magna Graecia University
Salvatore Venuta
Salvatore Venuta Magna Graecia University
Jerome Ritz
Jerome Ritz Harvard University
Catherine Brenner
Catherine Brenner Université Paris Cité
Edward S. Mocarski
Edward S. Mocarski Emory University

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