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Immunology

D-Index
80
Citations
35169
World Ranking
1598
National Ranking
797

Overview

Michael C. Jensen is affiliated with Seattle Children's Hospital in the United States. Their research primarily focuses on medicine, with a strong emphasis on oncology, immunology, genetics, molecular biology, and biomedical engineering.

The main topics of Michael C. Jensen's work include:

  • CAR-T cell therapy research
  • Nanowire synthesis and applications
  • Immunotherapy and immune responses
  • Glioma diagnosis and treatment
  • Virus-based gene therapy research
  • Advancements in semiconductor devices and circuit design
  • Immune cell function and interaction

Frequent publication venues for their work are:

  • Neuro-Oncology
  • Journal of Clinical Oncology
  • Cancer Research
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)

Michael C. Jensen has collaborated often with the following researchers:

  • Rebecca Gardner
  • Ashley Wilson
  • Julie R. Park
  • Nicholas A. Vitanza
  • Kristy Seidel

Notable recent papers include:

  • Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial, 2025, Nature Medicine
  • Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety, 2022, Cancer Discovery
  • Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma, 2022, Neuro-Oncology
  • Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis, 2021, Nature Medicine
  • Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses, 2020, Journal for ImmunoTherapy of Cancer

Their body of work comprises over 100 publications in medicine, predominantly in oncology and immunology subfields. This reflects an interdisciplinary approach integrating molecular biology and biomedical engineering principles to advance treatment strategies, particularly in CAR-T cell therapies and glioma.

Best Publications

  • Current concepts in the diagnosis and management of cytokine release syndrome

    Daniel W. Lee;Rebecca Gardner;David L. Porter;Chrystal U. Louis

  • CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

    Cameron J. Turtle;Laïla Aïcha Hanafi;Carolina Berger;Theodore A. Gooley

  • Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

    Brown Ce;Alizadeh D;Starr R;Weng L

  • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

    Andrew T Parsa;James S Waldron;Amith Panner;Courtney A Crane

  • Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults.

    Rebecca A. Gardner;Rebecca A. Gardner;Olivia Finney;Colleen Annesley;Colleen Annesley;Hannah Brakke

  • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.

    Brian G. Till;Brian G. Till;Michael C. Jensen;Jinjuan Wang;Eric Y. Chen

  • Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.

    Carolina Berger;Michael C. Jensen;Peter M. Lansdorp;Mike Gough

  • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma.

    Julie R. Park;David L. DiGiusto;Marilyn Slovak;Christine Wright

  • A transgene encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

    Xiuli Wang;Wen Chung Chang;ChingLam W. Wong;David Colcher

  • Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

    Rebecca Gardner;David Wu;Sindhu Cherian;Min Fang

  • CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results.

    Brian G. Till;Brian G. Till;Michael C. Jensen;Michael C. Jensen;Jinjuan Wang;Xiaojun Qian

  • CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor Enhances In vivo Persistence and Antitumor Efficacy of Adoptively Transferred T Cells

    Claudia M. Kowolik;Max S. Topp;Sergio Gonzalez;Timothy Pfeiffer

  • Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans

    Michael C. Jensen;Leslie Popplewell;Laurence J. Cooper;David DiGiusto

  • Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

    Michael Hudecek;Maria Teresa Lupo-Stanghellini;Paula L. Kosasih;Daniel Sommermeyer

  • T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells

    Eugenia Zah;Meng-Yin Lin;Anne Silva-Benedict;Michael C. Jensen

  • The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

    Michael Hudecek;Michael Hudecek;Daniel Sommermeyer;Paula L. Kosasih;Anne Silva-Benedict;Anne Silva-Benedict

  • T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

    Armen Mardiros;Cedric Dos Santos;Tinisha McDonald;Christine E. Brown

  • CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

    Elad Jacoby;Sang M. Nguyen;Thomas J. Fountaine;Kathryn Welp

  • Specific Recognition and Killing of Glioblastoma Multiforme by Interleukin 13-Zetakine Redirected Cytolytic T Cells

    Kanwarpal S. Kahlon;Christine Brown;Laurence J. N. Cooper;Andrew Raubitschek

  • Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.

    Shahriar S Yaghoubi;Michael C Jensen;Nagichettiar Satyamurthy;Shradha Budhiraja

  • Safety and immunologic effects of IL-15 administration in nonhuman primates.

    S. Carolina Berger;Michael Berger;Robert C. Hackman;Robert C. Hackman;Michael Gough

Frequent Co-Authors

Stanley R. Riddell
Stanley R. Riddell University of Washington
Stephen J. Forman
Stephen J. Forman City Of Hope National Medical Center
Laurence J.N. Cooper
Laurence J.N. Cooper The University of Texas MD Anderson Cancer Center
Philip D. Greenberg
Philip D. Greenberg Fred Hutchinson Cancer Research Center
Oliver W. Press
Oliver W. Press University of Washington
David G. Maloney
David G. Maloney Fred Hutchinson Cancer Research Center
Christine E. Brown
Christine E. Brown City Of Hope National Medical Center
Cameron J. Turtle
Cameron J. Turtle Fred Hutchinson Cancer Research Center
Brent L. Wood
Brent L. Wood University of Washington
Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)

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