World's Best Scientists 2026 revealed!

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Genetics

D-Index
82
Citations
47064
World Ranking
1444
National Ranking
678

Overview

Philip D. Gregory is affiliated with Sangamo BioSciences in the United States. Their research primarily intersects the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Oncology, Biomedical Engineering, Immunology, Genetics, and Molecular Biology.

The scientist has contributed to multiple areas of study including CAR-T cell therapy research, nanowire synthesis and applications, monoclonal and polyclonal antibodies research, advancements in semiconductor devices and circuit design, immune cell function and interaction, T-cell and B-cell immunology, and ocular disorders and treatments.

Frequent co-authors collaborating with Philip D. Gregory include Jordan Jarjour, Michael C. Jensen, Unja Martin, Alexander Astrakhan, and Christine E. Brown.

Publication venues for their work include:

  • UNC Libraries
  • Neuro-Oncology
  • Journal of Clinical Investigation
  • Cancer Research
  • Molecular Therapy

Representative recent papers authored or co-authored by Philip D. Gregory are:

  • Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma (2022, Neuro-Oncology)
  • Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing (2024, Journal of Clinical Investigation)
  • Ocular Gene Transfer with Self-Complementary AAV Vectors (2021, UNC Libraries)
  • Abstract 581: bbT369, a dual-targeted and CBLB gene-edited autologous CART product, demonstrates anti-lymphoma activity in preclinical mouse models (2022, Cancer Research)
  • Factors Associated with Potential Medication-Herb/Natural Product Interactions in a Rural Community (2020, UNC Libraries)

Philip D. Gregory's work encapsulates extensive investigation in CAR-T cell therapies, focusing on approaches such as generating steroid-resistant, IL13Rα2-specific CAR T cells for glioblastoma treatment and harnessing drug-regulated CD33-targeted CAR T cells for acute myeloid leukemia. This demonstrates a strong involvement in both the immunotherapy and genetic engineering aspects of oncology research.

The scientist also has engaged in research on ocular gene transfer techniques utilizing self-complementary AAV vectors, indicating an interest in gene therapy related to ocular disorders.

Additional topics covered include nanowire synthesis and applications alongside monoclonal and polyclonal antibodies research, highlighting a multidisciplinary approach crossing biomedical engineering and molecular biology domains.

Best Publications

  • Genome editing with engineered zinc finger nucleases

    Fyodor D. Urnov;Edward J. Rebar;Michael C. Holmes;H. Steve Zhang

  • A TALE nuclease architecture for efficient genome editing

    Jeffrey C Miller;Siyuan Tan;Guijuan Qiao;Kyle A Barlow

  • Highly efficient endogenous human gene correction using designed zinc-finger nucleases

    Fyodor D. Urnov;Jeffrey C. Miller;Ya-Li Lee;Christian M. Beausejour

  • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

    Pablo Tebas;David Stein;Winson W. Tang;Ian Frank

  • Genetic engineering of human pluripotent cells using TALE nucleases

    Dirk Hockemeyer;Haoyi Wang;Samira Kiani;Christine S Lai

  • An improved zinc-finger nuclease architecture for highly specific genome editing

    Jeffrey C Miller;Michael C Holmes;Jianbin Wang;Dmitry Y Guschin

  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

    Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis

  • Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

    Elena E. Perez;Jianbin Wang;Jeffrey C. Miller;Yann Jouvenot;Yann Jouvenot

  • Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

    Dirk Hockemeyer;Frank Soldner;Caroline Beard;Qing Gao

  • Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

    Aron M. Geurts;Gregory J. Cost;Yevgeniy Freyvert;Bryan Zeitler

  • Precise genome modification in the crop species Zea mays using zinc-finger nucleases

    Vipula K. Shukla;Yannick Doyon;Jeffrey C. Miller;Russell C. DeKelver

  • Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

    Yannick Doyon;Jasmine M McCammon;Jeffrey C Miller;Farhoud Faraji

  • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

    A. Lombardo;A. Lombardo;P. Genovese;P. Genovese;C.M. Beausejour;C.M. Beausejour;S. Colleoni;S. Colleoni

  • Histone deimination antagonizes arginine methylation

    Graeme L. Cuthbert;Sylvain Daujat;Andrew W. Snowden;Hediye Erdjument-Bromage

  • Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

    Frank Soldner;Josée Laganière;Albert W. Cheng;Dirk Hockemeyer

  • Targeted genome editing across species using ZFNs and TALENs.

    Andrew J. Wood;Te-Wen Lo;Bryan Zeitler;Catherine S. Pickle

  • K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

    Judith Straimer;Nina F. Gnädig;Benoit Witkowski;Chanaki Amaratunga

  • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

    Nathalia Holt;Jianbin Wang;Kenneth Kim;Geoffrey Friedman

  • Knockout rats generated by embryo microinjection of TALENs

    Laurent Tesson;Laurent Tesson;Laurent Tesson;Claire Usal;Claire Usal;Claire Usal;Séverine Ménoret;Séverine Ménoret;Séverine Ménoret;Elo Leung

  • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

    Wulan Deng;Wulan Deng;Jongjoo Lee;Hongxin Wang;Jeff Miller

Frequent Co-Authors

Michael C. Holmes
Michael C. Holmes Ambys Medicines
Edward J. Rebar
Edward J. Rebar Sangamo BioSciences (United States)
Fyodor D. Urnov
Fyodor D. Urnov University of California, Berkeley
Jeffrey C. Miller
Jeffrey C. Miller Sangamo BioSciences (United States)
Lei Zhang
Lei Zhang Sangamo BioSciences (United States)
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Chiara Bonini
Chiara Bonini Vita-Salute San Raffaele University
Adrian J. Thrasher
Adrian J. Thrasher University College London
Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia

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