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Immunology

D-Index
76
Citations
19717
World Ranking
1920
National Ranking
938

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Fabio Cominelli is affiliated with Case Western Reserve University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in several related subfields including Genetics, Molecular Biology, Immunology, Epidemiology, and Surgery.

Their work extensively addresses topics related to gastrointestinal health and immunological disorders. Major research themes include Inflammatory Bowel Disease, Gut microbiota and health, Microscopic Colitis, IL-33, ST2, and ILC Pathways, Eosinophilic Esophagitis, Gastrointestinal motility and disorders, and Probiotics and Fermented Foods.

Cominelli has contributed to a range of publications with frequent appearances in journals such as Gastroenterology, Inflammatory Bowel Diseases, The American Journal of Gastroenterology, bioRxiv (Cold Spring Harbor Laboratory), and Gut.

Frequent collaborators in Cominelli's research include:

  • Emad Mansoor
  • Theresa T. Pizarro
  • Alexander Rodriguez-Palacios
  • Vu Q. Nguyen
  • Abigail Basson

Notable recent papers authored or co-authored by Cominelli include:

  • Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health (2021, Gut Microbes)
  • ggpicrust2: an R package for PICRUSt2 predicted functional profile analysis and visualization (2023, Bioinformatics)
  • Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis (2020, Journal of Clinical Investigation)
  • The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease (2023, Gut)
  • Artificial Sweeteners: History and New Concepts on Inflammation (2021, Frontiers in Nutrition)

Cominelli has been recognized as a Member of the Association of American Physicians.

Best Publications

  • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.

    Dimitris Kontoyiannis;Manolis Pasparakis;Theresa Torres Pizarro;Fabio Cominelli

  • A guiding map for inflammation

    Mihai G Netea;Frances Balkwill;Michel Chonchol;Fabio Cominelli

  • IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

    Theresa T. Pizarro;Miette H. Michie;Marcia Bentz;Jan Woraratanadharm

  • Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

    Vincenzo Casini-Raggi;Lori Kam;Yoo Jin T Chong;Claudio Fiocchi

  • Probiotics promote gut health through stimulation of epithelial innate immunity

    Cristiano Pagnini;Rubina Saeed;Giorgos Bamias;Kristen O. Arseneau

  • Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

    F Cominelli;C C Nast;B D Clark;R Schindler

  • New Concepts in the Pathophysiology of Inflammatory Bowel Disease

    Giorgos Bamias;Mark R. Nyce;Sarah A. De La Rue;Fabio Cominelli

  • Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

    Giorgos Bamias;Charles Martin;Marco Marini;Sharon Hoang

  • Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.

    Dimitris Kontoyiannis;George Boulougouris;Menelaos Manoloukos;Maria Armaka

  • Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

    Yongyou Zhang;Amar Desai;Sung Yeun Yang;Sung Yeun Yang;Ki Beom Bae;Ki Beom Bae

  • Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

    Michele M. Kosiewicz;Cynthia C. Nast;Anasuya Krishnan;Jesus Rivera-Nieves

  • Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.

    Rita Del Pinto;Rita Del Pinto;Davide Pietropaoli;Davide Pietropaoli;Apoorva Krishna Chandar;Claudio Ferri

  • Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis

    Nikolaos A. Tountas;Vincenzo Casini–Raggi;Huiying Yang;Francesco S. Di Giovine

  • TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

    Marco Marini;Giorgos Bamias;Jesús Rivera-Nieves;Christopher A. Moskaluk

  • Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis

    Fabio Cominelli;Cynthia C. Nast;Andrea Duchini;Andrea Duchini;Marjorie Lee

  • The relationship between infliximab treatment and lymphoma in Crohn's disease

    Stephen J. Bickston;Gary R. Lichtenstein;Kristen O. Arseneau;Roger B. Cohen

  • Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

    Kenneth R. Youngman;Philip L. Simon;Gail A. West;Fabio Cominelli

  • Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease.

    Masaru Odashima;Giorgos Bamias;Jesus Rivera-Nieves;Joel Linden

  • Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice.

    R.Cartland Burns;Jesus Rivera-Nieves;Christopher A. Moskaluk;Satoshi Matsumoto

  • Mouse models for the study of Crohn's disease

    Theresa T. Pizarro;Kristen O. Arseneau;Giorgos Bamias;Fabio Cominelli

Frequent Co-Authors

Theresa T. Pizarro
Theresa T. Pizarro Case Western Reserve University
Christopher A. Moskaluk
Christopher A. Moskaluk University of Virginia
Klaus Ley
Klaus Ley Augusta University
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
Massimo Pinzani
Massimo Pinzani The Royal Free Hospital
Mahmoud A. Ghannoum
Mahmoud A. Ghannoum Case Western Reserve University
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Peter B. Ernst
Peter B. Ernst University of California, San Diego
Claudio Fiocchi
Claudio Fiocchi Cleveland Clinic Lerner College of Medicine
Michael T. Heneka
Michael T. Heneka University Hospital Bonn

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