Takanari Gotoda

Overview

Best Publications

• Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

  Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo;Alyssa H. Hasty

  818
  Citations

• Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

  Tomohiro Yoshikawa;Hitoshi Shimano;Michiyo Amemiya-Kudo;Naoya Yahagi

  628
  Citations

• Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

  Tomohiro Yoshikawa;Hitoshi Shimano;Naoya Yahagi;Tomohiro Ide

  509
  Citations

• Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

  Michiyo Amemiya-Kudo;Hitoshi Shimano;Alyssa H. Hasty;Naoya Yahagi

  454
  Citations

• Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

  Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Takashi Matsuzaka

  453
  Citations

• A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

  Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Michiyo Amemiya-Kudo

  440
  Citations

• Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

  Zhong Chen;Shun Ishibashi;Stéphane Perrey;Jun-ichi Osuga

  431
  Citations

• Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

  Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  347
  Citations

• Enhanced Aldosterone Signaling in the Early Nephropathy of Rats with Metabolic Syndrome: Possible Contribution of Fat-Derived Factors

  Miki Nagase;Shigetaka Yoshida;Shigeru Shibata;Takashi Nagase

  340
  Citations

• The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

  Hiroyuki Mori;Hiroshi Ikegami;Yoshihiko Kawaguchi;Susumu Seino

  335
  Citations

• Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene*

  Michiyo Amemiya-Kudo;Hitoshi Shimano;Tomohiro Yoshikawa;Naoya Yahagi

  302
  Citations

• Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor *

  Alyssa H. Hasty;Hitoshi Shimano;Jun-ichi Osuga;Ichiji Namatame

  283
  Citations

• Leptin receptor gene variation and obesity: lack of association in a white British male population.

  Gotoda T;Manning Bs;Manning Bs;Goldstone Ap;Imrie H

  274
  Citations

• Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) α and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling

  Tomohiro Ide;Hitoshi Shimano;Tomohiro Yoshikawa;Naoya Yahagi

  264
  Citations

• Adult-Onset Spinocerebellar Dysfunction Caused by a Mutation in the Gene for the α-Tocopherol–Transfer Protein

  Takanari Gotoda;Makoto Arita;Hiroyuki Arai;Keizo Inoue

  256
  Citations

• p53 Activation in Adipocytes of Obese Mice

  Naoya Yahagi;Hitoshi Shimano;Takashi Matsuzaka;Yuho Najima

  248
  Citations

• Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia

  Hiroaki Yagyu;Tetsuya Kitamine;Jun-ichi Osuga;Ryu-ichi Tozawa

  228
  Citations

• Salt-Induced Nephropathy in Obese Spontaneously Hypertensive Rats Via Paradoxical Activation of the Mineralocorticoid Receptor: Role of Oxidative Stress

  Miki Nagase;Hiromitsu Matsui;Shigeru Shibata;Takanari Gotoda

  217
  Citations

• Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

  H Shimano;J Ohsuga;M Shimada;Y Namba

  202
  Citations

• Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

  Hitoshi Shimano;Nobuhiro Yamada;Motoya Katsuki;Masaka Shimada

  196
  Citations