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Biology and Biochemistry

D-Index
62
Citations
16488
World Ranking
10650
National Ranking
725

Overview

Naoya Yahagi is affiliated with the University of Tsukuba in Japan and focuses on research in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular biology, surgery, cancer research, endocrinology, diabetes, metabolism, and genetics.

The scientist's research covers multiple significant topics, such as Kruppel-like factors research, peroxisome proliferator-activated receptors, cholesterol and lipid metabolism, pancreatic function and diabetes, cancer-related molecular mechanisms, balance, gait, and falls prevention, as well as diet, metabolism, and disease.

Naoya Yahagi has authored numerous papers, some of which include:

  • Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis (2024, Nature Communications)
  • Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models (2023, JCI Insight)
  • The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay (2020, PeerJ)
  • Rapid manipulation of mitochondrial morphology in a living cell with iCMM (2021, Cell Reports Methods)
  • Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice (2022, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease)

Frequent co-authors collaborating with Naoya Yahagi include:

  • Yoshinori Takeuchi
  • Hitoshi Shimano
  • Yuichi Aita
  • Takashi Matsuzaka
  • Motohiro Sekiya

The main publication venues where Naoya Yahagi's research has appeared are:

  • Biochemical and Biophysical Research Communications
  • Preprints.org
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • F1000Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

    Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo;Alyssa H. Hasty

  • Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

    Jun-ichi Osuga;Shun Ishibashi;Teruaki Oka;Hiroaki Yagyu

  • Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

    Tomohiro Yoshikawa;Hitoshi Shimano;Michiyo Amemiya-Kudo;Naoya Yahagi

  • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

    Tomohiro Yoshikawa;Hitoshi Shimano;Naoya Yahagi;Tomohiro Ide

  • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

    Motohiro Sekiya;Naoya Yahagi;Takashi Matsuzaka;Yuho Najima

  • Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Alyssa H. Hasty;Naoya Yahagi

  • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Takashi Matsuzaka

  • A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Michiyo Amemiya-Kudo

  • SREBPs suppress IRS-2-mediated insulin signalling in the liver

    Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi;Takashi Matsuzaka

  • Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

    Zhong Chen;Shun Ishibashi;Stéphane Perrey;Jun-ichi Osuga

  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

    Tomohiro Yoshikawa;Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi

  • Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  • Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

    Hideki Abe;Nobuhiro Yamada;Katsuo Kamata;Tomoyuki Kuwaki

  • Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene*

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Tomohiro Yoshikawa;Naoya Yahagi

  • Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor *

    Alyssa H. Hasty;Hitoshi Shimano;Jun-ichi Osuga;Ichiji Namatame

  • Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.

    Naoya Yahagi;Hitoshi Shimano;Kiyoshi Hasegawa;Kenichi Ohashi

  • Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) α and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling

    Tomohiro Ide;Hitoshi Shimano;Tomohiro Yoshikawa;Naoya Yahagi

  • The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice

    Noriko Nakanishi;Yoshimi Nakagawa;Naoko Tokushige;Naohito Aoki

  • Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Tomohiro Yoshikawa

  • p53 Activation in Adipocytes of Obese Mice

    Naoya Yahagi;Hitoshi Shimano;Takashi Matsuzaka;Yuho Najima

Frequent Co-Authors

Hitoshi Shimano
Hitoshi Shimano University of Tsukuba
Nobuhiro Yamada
Nobuhiro Yamada University of Tsukuba
Shun Ishibashi
Shun Ishibashi Jichi Medical University
Hirohito Sone
Hirohito Sone Niigata University
Takanari Gotoda
Takanari Gotoda Kyorin University
Kazuto Kobayashi
Kazuto Kobayashi Fukushima Medical University
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Takashi Yamamoto
Takashi Yamamoto Hiroshima University
Alyssa H. Hasty
Alyssa H. Hasty Vanderbilt University

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