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Hitoshi Shimano

Hitoshi Shimano

D-Index & Metrics

Medicine

D-Index
101
Citations
42862
World Ranking
7897
National Ranking
199

Overview

Hitoshi Shimano is affiliated with the University of Tsukuba in Japan and has an extensive research portfolio primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Biology, Endocrinology, Diabetes and Metabolism, Surgery, Physiology, and Immunology.

The primary topics covered in Shimano's research include Kruppel-like factors research, pancreatic function and diabetes, diabetes-related cardiovascular risks and lipoproteins, peroxisome proliferator-activated receptors, cholesterol and lipid metabolism, trigeminal neuralgia and its treatments, and diabetes treatment and management.

Frequent coauthors in their collaborative work include Takashi Matsuzaka, Yoshimi Nakagawa, Motohiro Sekiya, Hirohito Sone, and Yoshinori Osaki.

Shimada has published multiple articles in several key scientific venues. The most frequent publication outlets are Scientific Reports, Journal of Atherosclerosis and Thrombosis, Nutrients, bioRxiv (Cold Spring Harbor Laboratory), and Journal of Diabetes Investigation.

Some recent publications include:

  • Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis (2020, ESC Heart Failure)
  • Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study (2021, Neurosurgery)
  • Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021, Journal of Gastroenterology)
  • Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes (2020, Scientific Reports)
  • ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma (2021, Oncology Reports)

Best Publications

  • Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis

    Satoru Kodama;Kazumi Saito;Shiro Tanaka;Miho Maki

  • SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

    Hitoshi Shimano;Ryuichiro Sato

  • Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

    Hitoshi Shimano

  • EFFECT OF AEROBIC EXERCISE TRAINING ON SERUM LEVELS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: A META-ANALYSIS

    Satoru Kodama;Shiro Tanaka;Kazumi Saito;Miao Shu

  • Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

    Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo;Alyssa H. Hasty

  • TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.

    Mitsuo Kato;Sumanth Putta;Mei Wang;Hang Yuan

  • Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

    Hitoshi Shimano;Iichiro Shimomura;Robert E. Hammer;Joachim Herz

  • Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

    Tomohiro Yoshikawa;Hitoshi Shimano;Michiyo Amemiya-Kudo;Naoya Yahagi

  • Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Naoya Yahagi;Toyonori Kato

  • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

    Tomohiro Yoshikawa;Hitoshi Shimano;Naoya Yahagi;Tomohiro Ide

  • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

    Motohiro Sekiya;Naoya Yahagi;Takashi Matsuzaka;Yuho Najima

  • Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Alyssa H. Hasty;Naoya Yahagi

  • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Takashi Matsuzaka

  • A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Michiyo Amemiya-Kudo

  • SREBPs suppress IRS-2-mediated insulin signalling in the liver

    Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi;Takashi Matsuzaka

  • Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

    Zhong Chen;Shun Ishibashi;Stéphane Perrey;Jun-ichi Osuga

  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

    Tomohiro Yoshikawa;Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi

  • Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  • Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis.

    Chika Horikawa;Satoru Kodama;Yoko Yachi;Yoriko Heianza

  • HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

    Yoriko Heianza;Shigeko Hara;Yasuji Arase;Kazumi Saito

Frequent Co-Authors

Nobuhiro Yamada
Nobuhiro Yamada University of Tsukuba
Hirohito Sone
Hirohito Sone Niigata University
Naoya Yahagi
Naoya Yahagi University of Tsukuba
Shun Ishibashi
Shun Ishibashi Jichi Medical University
Takanari Gotoda
Takanari Gotoda Kyorin University
Kazuto Kobayashi
Kazuto Kobayashi Fukushima Medical University
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Takashi Yamamoto
Takashi Yamamoto Hiroshima University
Alyssa H. Hasty
Alyssa H. Hasty Vanderbilt University

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