World's Best Scientists 2026 revealed!
Hitoshi Shimano

Hitoshi Shimano

D-Index & Metrics

Medicine

D-Index
101
Citations
42862
World Ranking
7897
National Ranking
199

Hitoshi Shimano publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where Hitoshi Shimano sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 611 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 441 publications — 47th percentile

47% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

Hitoshi Shimano D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where Hitoshi Shimano sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 400 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 101 D-Index — 61st percentile

61% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Overview

Hitoshi Shimano is affiliated with the University of Tsukuba in Japan and has an extensive research portfolio primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Biology, Endocrinology, Diabetes and Metabolism, Surgery, Physiology, and Immunology.

The primary topics covered in Shimano's research include Kruppel-like factors research, pancreatic function and diabetes, diabetes-related cardiovascular risks and lipoproteins, peroxisome proliferator-activated receptors, cholesterol and lipid metabolism, trigeminal neuralgia and its treatments, and diabetes treatment and management.

Frequent coauthors in their collaborative work include Takashi Matsuzaka, Yoshimi Nakagawa, Motohiro Sekiya, Hirohito Sone, and Yoshinori Osaki.

Shimada has published multiple articles in several key scientific venues. The most frequent publication outlets are Scientific Reports, Journal of Atherosclerosis and Thrombosis, Nutrients, bioRxiv (Cold Spring Harbor Laboratory), and Journal of Diabetes Investigation.

Some recent publications include:

  • Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis (2020, ESC Heart Failure)
  • Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study (2021, Neurosurgery)
  • Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021, Journal of Gastroenterology)
  • Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes (2020, Scientific Reports)
  • ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma (2021, Oncology Reports)

Best Publications

  • Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis

    Satoru Kodama;Kazumi Saito;Shiro Tanaka;Miho Maki

  • SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

    Hitoshi Shimano;Ryuichiro Sato

  • Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

    Hitoshi Shimano

  • EFFECT OF AEROBIC EXERCISE TRAINING ON SERUM LEVELS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: A META-ANALYSIS

    Satoru Kodama;Shiro Tanaka;Kazumi Saito;Miao Shu

  • Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

    Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo;Alyssa H. Hasty

  • TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.

    Mitsuo Kato;Sumanth Putta;Mei Wang;Hang Yuan

  • Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

    Hitoshi Shimano;Iichiro Shimomura;Robert E. Hammer;Joachim Herz

  • Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

    Tomohiro Yoshikawa;Hitoshi Shimano;Michiyo Amemiya-Kudo;Naoya Yahagi

  • Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Naoya Yahagi;Toyonori Kato

  • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

    Tomohiro Yoshikawa;Hitoshi Shimano;Naoya Yahagi;Tomohiro Ide

  • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

    Motohiro Sekiya;Naoya Yahagi;Takashi Matsuzaka;Yuho Najima

  • Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

    Michiyo Amemiya-Kudo;Hitoshi Shimano;Alyssa H. Hasty;Naoya Yahagi

  • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Takashi Matsuzaka

  • A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

    Naoya Yahagi;Hitoshi Shimano;Alyssa H. Hasty;Michiyo Amemiya-Kudo

  • SREBPs suppress IRS-2-mediated insulin signalling in the liver

    Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi;Takashi Matsuzaka

  • Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL

    Zhong Chen;Shun Ishibashi;Stéphane Perrey;Jun-ichi Osuga

  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

    Tomohiro Yoshikawa;Tomohiro Ide;Hitoshi Shimano;Naoya Yahagi

  • Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

    Takashi Matsuzaka;Hitoshi Shimano;Naoya Yahagi;Michiyo Amemiya-Kudo

  • Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis.

    Chika Horikawa;Satoru Kodama;Yoko Yachi;Yoriko Heianza

  • HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

    Yoriko Heianza;Shigeko Hara;Yasuji Arase;Kazumi Saito

Frequent Co-Authors

Nobuhiro Yamada
Nobuhiro Yamada University of Tsukuba
Hirohito Sone
Hirohito Sone Niigata University
Naoya Yahagi
Naoya Yahagi University of Tsukuba
Shun Ishibashi
Shun Ishibashi Jichi Medical University
Takanari Gotoda
Takanari Gotoda Kyorin University
Kazuto Kobayashi
Kazuto Kobayashi Fukushima Medical University
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Takashi Yamamoto
Takashi Yamamoto Hiroshima University
Alyssa H. Hasty
Alyssa H. Hasty Vanderbilt University

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