World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
34117
World Ranking
2414
National Ranking
1281

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Fellow of American Physical Society (APS) Citation For pioneering contributions in the field of molecular biomechanics and seminal impacts in developing molecular sensors for diagnosis of cellular functions

Overview

Gang Bao is affiliated with Rice University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, they have contributed extensively to subfields including Molecular Biology, Genetics, Biomedical Engineering, Immunology, and Pulmonary and Respiratory Medicine.

The scientist's main research topics include:

  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Nanoparticle-Based Drug Delivery
  • Cystic Fibrosis Research Advances
  • RNA Interference and Gene Delivery
  • Hemoglobinopathies and Related Disorders

Gang Bao has coauthored numerous papers with frequent collaborators such as Ciaran M. Lee (17 joint publications), William R. Lagor (12), Linlin Zhang (10), Qingbo Zhang (9), and Matthew H. Porteus (8).

The scientist's work has appeared in various publication venues, including:

  • arXiv (Cornell University)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cystic Fibrosis
  • Blood
  • Science Advances

Selected recent papers include:

  • "AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9," 2020, Molecular Therapy
  • "Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease," 2021, Science Translational Medicine
  • "The NIH Somatic Cell Genome Editing program," 2021, Nature
  • "CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells," 2020, Science Advances
  • "Tools for experimental and computational analyses of off-target editing by programmable nucleases," 2020, Nature Protocols

In addition to journal articles, Gang Bao has contributed to academic books, including a publication through Springer Nature titled "Maxwell's Equations in Periodic Structures" published in 2021.

Their professional recognition includes election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009 and as a Fellow of the American Physical Society (APS) in 2007. The APS fellowship citation notes contributions in molecular biomechanics and the development of molecular sensors for diagnosing cellular functions.

Best Publications

  • DNA targeting specificity of RNA-guided Cas9 nucleases

    Patrick D Hsu;David Arthur Scott;David Arthur Scott;Joshua A Weinstein;Joshua A Weinstein;F. Ann Ran;F. Ann Ran;F. Ann Ran

  • The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.

    Nazanin Hoshyar;Samantha Gray;Hongbin Han;Gang Bao;Gang Bao

  • Cell and molecular mechanics of biological materials

    G. Bao;S. Suresh

  • Physical Principles of Nanoparticle Cellular Endocytosis.

    Sulin Zhang;Huajian Gao;Gang Bao

  • CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

    Thomas J. Cradick;Eli J. Fine;Christopher J. Antico;Gang Bao

  • Particle reinforcement of ductile matrices against plastic flow and creep

    G. Bao;J.W. Hutchinson;R.M. McMeeking

  • CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

    Yanni Lin;Thomas J. Cradick;Matthew T. Brown;Harshavardhan Deshmukh

  • A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.

    Christopher A. Vakulskas;Daniel P. Dever;Garrett R. Rettig;Rolf Turk

  • Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

    Gang Bao;Samir Mitragotri;Sheng Tong

  • Cell mechanics: mechanical response, cell adhesion, and molecular deformation.

    Cheng Zhu;Gang Bao;Ning Wang

  • CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery

    Hong-Xia Wang;Mingqiang Li;Ciaran M. Lee;Syandan Chakraborty

  • Dual FRET molecular beacons for mRNA detection in living cells

    Philip J. Santangelo;Brent Nix;Andrew Tsourkas;Gang Bao

  • Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent.

    N. Nitin;L. E. W. LaConte;O. Zurkiya;X. Hu

  • The biomechanics toolbox: experimental approaches for living cells and biomolecules

    K.J Van Vliet;K.J Van Vliet;G Bao;S Suresh

  • Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

    Lin Ye;Jiaming Wang;Ashley I. Beyer;Fernando Teque

  • COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

    Thomas J Cradick;Peng Qiu;Ciaran M Lee;Eli J Fine

  • CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.

    Diogo Gomes-Silva;Madhuwanti Srinivasan;Madhuwanti Srinivasan;Madhuwanti Srinivasan;Sandhya Sharma;Sandhya Sharma;Sandhya Sharma;Ciaran M. Lee

  • Multiple cracking in functionally graded ceramic/metal coatings

    G. Bao;L. Wang

  • Quantum Dot-Fluorescent Protein FRET Probes for Sensing Intracellular pH

    Allison M. Dennis;Won Jong Rhee;David Sotto;Steven N. Dublin

  • Hybridization kinetics and thermodynamics of molecular beacons

    Andrew Tsourkas;Mark A. Behlke;Scott D. Rose;Gang Bao

Frequent Co-Authors

Matthew H. Porteus
Matthew H. Porteus Stanford University
Zhong Lin Wang
Zhong Lin Wang Georgia Institute of Technology
Toni Cathomen
Toni Cathomen University of Freiburg
Horacio D. Espinosa
Horacio D. Espinosa Northwestern University
Zhifei Dai
Zhifei Dai Peking University
Andrew M. Scharenberg
Andrew M. Scharenberg Seattle Children's Hospital
Mark A. Behlke
Mark A. Behlke Integrated DNA Technologies (United States)
Zhigang Suo
Zhigang Suo Harvard University
David Roth
David Roth University of Miami

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