World's Best Scientists 2026 revealed!
Charles A. Gersbach

Charles A. Gersbach

D-Index & Metrics

Molecular Biology

D-Index
67
Citations
25867
World Ranking
1545
National Ranking
782

Research.com Recognitions

  • 2017 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Charles A. Gersbach is affiliated with Duke University in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology and genetics. They have published over 120 works primarily in these domains, exploring topics related to CRISPR and genetic engineering, virus-based gene therapy, and CAR-T cell therapy among others.

Their research spans several main topics, including:

  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Genomics and Chromatin Dynamics
  • RNA regulation and disease
  • RNA Interference and Gene Delivery
  • Muscle Physiology and Disorders

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Regular and Young Investigator Award Abstracts
  • Nucleic Acids Research
  • Nature Methods

Some of the recent papers featuring work associated with their research topics are:

  • The once and future gene therapy, 2020, Nature Communications
  • Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models, 2021, Nature Communications
  • Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems, 2020, Nucleic Acids Research
  • The NIH Somatic Cell Genome Editing program, 2021, Nature
  • Transgenic mice for in vivo epigenome editing with CRISPR-based systems, 2021, Nature Methods

Collaborations are an important component of their work, with frequent co-authors including:

  • Alejandro Barrera
  • Aravind Asokan
  • Sean R. McCutcheon
  • Timothy E. Reddy
  • Keith Siklenka

The body of work they have contributed to covers a significant amount of research into gene editing technologies, genome dynamics, and therapeutic methodologies, reflecting a multidisciplinary approach centered around molecular and cellular biology.

In recognition of contributions to engineering and technology, they were awarded the title of Fellow of the Indian National Academy of Engineering (INAE) in 2017.

Best Publications

  • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

    Thomas Gaj;Charles A. Gersbach;Carlos F. Barbas

  • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

    Isaac B Hilton;Anthony M D'Ippolito;Christopher M Vockley;Pratiksha I Thakore

  • RNA-guided gene activation by CRISPR-Cas9-based transcription factors

    Pablo Perez-Pinera;D Dewran Kocak;Christopher M Vockley;Andrew F Adler

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

    Christopher E. Nelson;Chady H. Hakim;David G. Ousterout;Pratiksha I. Thakore

  • The next generation of CRISPR-Cas technologies and applications.

    Adrian Pickar-Oliver;Charles A. Gersbach

  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

    Pratiksha I Thakore;Anthony M D'Ippolito;Lingyun Song;Alexias Safi

  • Genome-editing Technologies for Gene and Cell Therapy

    Morgan L Maeder;Charles A Gersbach

  • A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

    Lauren R Polstein;Charles A Gersbach

  • Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy

    David G. Ousterout;Ami M. Kabadi;Pratiksha I. Thakore;William H. Majoros

  • Editing the epigenome: technologies for programmable transcription and epigenetic modulation

    Pratiksha I Thakore;Joshua B Black;Isaac B Hilton;Charles A Gersbach

  • CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

    Tyler S Klann;Joshua B Black;Malathi Chellappan;Alexias Safi

  • Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

    Ami M. Kabadi;David G. Ousterout;Isaac B. Hilton;Charles A. Gersbach

  • Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

    Christopher E. Nelson;Yaoying Wu;Matthew P. Gemberling;Matthew L. Oliver

  • Synergistic and tunable human gene activation by combinations of synthetic transcription factors

    Pablo Perez-Pinera;David G Ousterout;Jonathan M Brunger;Alicia M Farin

  • Increasing the specificity of CRISPR systems with engineered RNA secondary structures.

    D. Dewran Kocak;Eric A. Josephs;Eric A. Josephs;Vidit Bhandarkar;Shaunak S. Adkar

  • How vinculin regulates force transmission

    David W. Dumbauld;Ted T. Lee;Ankur Singh;Jan Scrimgeour

  • Advances in targeted genome editing

    Pablo Perez-Pinera;David G Ousterout;Charles A Gersbach

  • The once and future gene therapy

    Karen Bulaklak;Charles A. Gersbach

  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries

    Michael A. Lan;Charles A. Gersbach;Kristin E. Michael;Benjamin G. Keselowsky

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

    C. E. Nelson;C. H. Hakim;D. G. Ousterout;P. I. Thakore

Frequent Co-Authors

Farshid Guilak
Farshid Guilak Washington University in St. Louis
Gregory E. Crawford
Gregory E. Crawford Duke University
Andrés J. García
Andrés J. García Georgia Institute of Technology
Carlos F. Barbas
Carlos F. Barbas Scripps Research Institute
Kam W. Leong
Kam W. Leong Columbia University
Aravind Asokan
Aravind Asokan Duke University
Lingyun Song
Lingyun Song Duke University
Dongsheng Duan
Dongsheng Duan University of Missouri
Rodolphe Barrangou
Rodolphe Barrangou North Carolina State University

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