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Biology and Biochemistry

D-Index
53
Citations
17540
World Ranking
15920
National Ranking
58

Overview

Andre Choo is affiliated with the Agency for Science, Technology and Research in Singapore. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these, their prominent subfields include Molecular Biology, Radiology, Nuclear Medicine and Imaging, Immunology, Genetics, and Oncology.

Their research contributions focus on several specialized topics. These include:

  • Extracellular vesicles in disease
  • Monoclonal and Polyclonal Antibodies Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Mesenchymal stem cell research
  • MicroRNA in disease regulation
  • Glycosylation and Glycoproteins Research
  • Dermatology and Skin Diseases

Andre Choo has coauthored frequently with several researchers, including Sai Kiang Lim, Ruenn Chai Lai, Ying Swan Ho, Ian Walsh, and Bin Zhang.

Their recent published papers illustrate a focus on mesenchymal stem cell-derived small extracellular vesicles and their therapeutic applications. Selected works include:

  • "Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles," 2021, Cytotherapy
  • "Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation," 2021, International Journal of Molecular Sciences
  • "Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes," 2022, Cytotherapy
  • "Mesenchymal Stem Cell Exosomes Promote Functional Osteochondral Repair in a Clinically Relevant Porcine Model," 2022, The American Journal of Sports Medicine
  • "Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)," 2021, Pharmaceuticals

Their frequent publication venues are Cytotherapy, International Journal of Molecular Sciences, Scientific Reports, Pharmaceuticals, and Journal of Extracellular Vesicles. Cytotherapy stands out as the most common venue for their articles.

Best Publications

  • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

    Ruenn Chai Lai;Fatih Arslan;May May Lee;Newman Siu Kwan Sze

  • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

    Fatih Arslan;Ruenn Chai Lai;Ruenn Chai Lai;Mirjam B. Smeets;Lars Akeroyd

  • Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

    Oluseun Adewumi;Behrouz Aflatoonian;Lars Ahrlund-Richter;Michal Amit

  • Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.

    Leo Timmers;Sai Kiang Lim;Fatih Arslan;Jeffrey S. Armstrong

  • Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

    Tian Sheng Chen;Ruenn Chai Lai;May May Lee;Andre Boon Hwa Choo

  • Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.

    Xiao Dong Zhao;Xu Han;Joon Lin Chew;Joon Lin Chew;Jun Liu

  • Mesenchymal stem cells secrete immunologically active exosomes.

    Bin Zhang;Yijun Yin;Ruenn Chai Lai;Soon Sim Tan

  • Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

    Katherine Amps;Peter W. Andrews;George Anyfantis;Lyle Armstrong

  • Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

    Ruenn Chai Lai;Soon Sim Tan;Bao Ju Teh;Siu Kwan Sze

  • Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

    Leo Timmers;Sai Kiang Lim;Imo E. Hoefer;Fatih Arslan

  • Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

    Kenneth W. Witwer;Bas W.M. Van Balkom;Stefania Bruno;Andre Choo

  • Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs.

    Tian Sheng Chen;Fatih Arslan;Yijun Yin;Soon Sim Tan

  • Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1.

    Andre B Choo;Heng Liang Tan;Sheu Ngo Ang;Wey Jia Fong

  • Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells.

    Wei Seong Toh;Eng Hin Lee;Xi-Min Guo;Jerry K.Y. Chan;Jerry K.Y. Chan

  • Long-term microcarrier suspension cultures of human embryonic stem cells.

    Steve K.W. Oh;Allen K. Chen;Yanglin Mok;Xiaoli Chen

  • MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA.

    Ruenn Chai Lai;Soon Sim Tan;Ronne Wee Yeh Yeo;Andre Boon Hwa Choo

  • Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells.

    Allen Kuan-Liang Chen;Xiaoli Chen;Andre Boon Hwa Choo;Shaul Reuveny

  • In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling

    Paul J. Boersema;Leong Yan Foong;Vanessa M.Y. Ding;Simone Lemeer

  • Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane

    Soon Sim Tan;Yijun Yin;Tricia Lee;Ruenn Chai Lai

  • Derivation and characterization of human fetal MSCs: An alternative cell source for large-scale production of cardioprotective microparticles

    Ruenn Chai Lai;Ruenn Chai Lai;Fatih Arslan;Soon Sim Tan;Betty Tan

Frequent Co-Authors

Steve Oh
Steve Oh A*STAR - Agency for Science, Technology and Research
Sai Kiang Lim
Sai Kiang Lim Agency for Science, Technology and Research
Dong-Yup Lee
Dong-Yup Lee Sungkyunkwan University
Evert Klaseboer
Evert Klaseboer Institute of High Performance Computing
Gerard Pasterkamp
Gerard Pasterkamp Utrecht University
Claus-Dieter Ohl
Claus-Dieter Ohl Otto-von-Guericke University Magdeburg
Simon M. Cool
Simon M. Cool University of Queensland
Alois Jungbauer
Alois Jungbauer BOKU University
Huck-Hui Ng
Huck-Hui Ng Genome Institute of Singapore
Siu Kwan Sze
Siu Kwan Sze Nanyang Technological University

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