World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
23396
World Ranking
6887
National Ranking
3174

Research.com Recognitions

  • 2014 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Sean P. Palecek is affiliated with the University of Wisconsin-Madison in the United States. Their research spans multiple fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine. Key subfields of their work include molecular biology, neurology, surgery, biomedical engineering, and cancer research.

The scientist's body of work covers diverse topics such as pluripotent stem cells research, barrier structure and function studies, tissue engineering and regenerative medicine, 3D printing in biomedical research, congenital heart defects research, single-cell and spatial transcriptomics, and cardiac fibrosis and remodeling.

Frequent coauthors in their research include Eric V. Shusta, Benjamin D. Gastfriend, Aaron D. Simmons, Martha E. Floy, and Koji L. Foreman. These collaborations have contributed to the depth and range of their scientific investigations.

Sean P. Palecek has published extensively in several scientific outlets. The venues with the highest frequency of their publications include bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, ACS Applied Materials & Interfaces, Journal of Molecular and Cellular Cardiology, and Fluids and Barriers of the CNS.

Notable recent papers encompass the following:

  • Transcriptomic comparison of human and mouse brain microvessels (2020) in Scientific Reports
  • A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology (2021) in Nature Medicine
  • Commentary on human pluripotent stem cell-based blood-brain barrier models (2020) in Fluids and Barriers of the CNS
  • Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis (2022) in Brain
  • Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions (2020) in The FASEB Journal

Among recognized honors, Sean P. Palecek was named a Fellow of the Indian National Academy of Engineering (INAE) in 2014.

Best Publications

  • Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

    Sean P. Palecek;Joseph C. Loftus;Mark H. Ginsberg;Douglas A. Lauffenburger

  • Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

    Xiaojun Lian;Cheston Hsiao;Gisela Wilson;Kexian Zhu

  • Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

    Xiaojun Lian;Jianhua Zhang;Samira M Azarin;Kexian Zhu

  • Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

    Jianhua Zhang;Gisela F. Wilson;Andrew G. Soerens;Chad H. Koonce

  • Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

    Ethan S Lippmann;Samira M Azarin;Jennifer E Kay;Randy A Nessler

  • Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells: The Matrix Sandwich Method

    Jianhua Zhang;Matthew Klos;Gisela F. Wilson;Amanda M. Herman

  • Regulation of Cell Migration by the Calcium-dependent Protease Calpain

    Anna Huttenlocher;Sean P. Palecek;Qin Lu;Wenli Zhang

  • A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

    Ethan S. Lippmann;Abraham Al-Ahmad;Samira M. Azarin;Sean P. Palecek

  • Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.

    Tae-Eun Park;Nur Mustafaoglu;Anna Herland;Anna Herland;Anna Herland;Ryan Hasselkus

  • Physical and biochemical regulation of integrin release during rear detachment of migrating cells.

    Sean P. Palecek;Anna Huttenlocher;Alan F. Horwitz;Douglas A. Lauffenburger

  • Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling

    Xiaojun Lian;Xiaoping Bao;Abraham Al-Ahmad;Jialu Liu

  • 3-D microwell culture of human embryonic stem cells

    Jeffrey C. Mohr;Jeffrey C. Mohr;Juan J. de Pablo;Juan J. de Pablo;Sean P. Palecek;Sean P. Palecek

  • The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells.

    Jeffrey C. Mohr;Jianhua Zhang;Samira M. Azarin;Andrew G. Soerens

  • Integrin dynamics on the tail region of migrating fibroblasts.

    Sean P. Palecek;Christine E. Schmidt;Douglas A. Lauffenburger;Alan F. Horwitz

  • Effects of Substrate Mechanics on Contractility of Cardiomyocytes Generated from Human Pluripotent Stem Cells

    Laurie B. Hazeltine;Chelsey S. Simmons;Max R. Salick;Xiaojun Lian

  • EAP1, a Candida albicans gene involved in binding human epithelial cells.

    Fang Li;Sean P. Palecek

  • An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells.

    Scott G. Canfield;Matthew J. Stebbins;Bethsymarie Soto Morales;Shusaku W. Asai

  • Inhibition of human embryonic stem cell differentiation by mechanical strain

    Somen Saha;Lin Ji;Juan J. de Pablo;Sean P. Palecek

  • Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier

    Gad D. Vatine;Abraham Al-Ahmad;Abraham Al-Ahmad;Bianca K. Barriga;Soshana Svendsen

  • Erratum: Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness (Nature (1997) 385 (537-540))

    Sean P. Palecek;Joseph C. Loftus;Mark H. Ginsberg;Douglas A. Lauffenburger

Frequent Co-Authors

Eric V. Shusta
Eric V. Shusta University of Wisconsin–Madison
Juan J. de Pablo
Juan J. de Pablo New York University
David M. Lynn
David M. Lynn University of Wisconsin–Madison
Timothy J. Kamp
Timothy J. Kamp University of Wisconsin–Madison
Stephen J. Kron
Stephen J. Kron University of Chicago
Christian M. Metallo
Christian M. Metallo University of California, San Diego
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison
Donald E. Ingber
Donald E. Ingber Harvard University
James A. Thomson
James A. Thomson University of California, Santa Barbara

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