2026 Douglas A. Lauffenburger: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	140	127	112	84	74	681	72084

Research.com Recognitions

2026 - Research.com Molecular Biology in United States Leader Award
2025 - Research.com Molecular Biology in United States Leader Award
2023 - Research.com Molecular Biology in United States Leader Award
2019 - Fellow of the American Association for the Advancement of Science (AAAS)
2001 - Fellow of the American Academy of Arts and Sciences
2001 - Member of the National Academy of Engineering For contributions in molecular and cellular engineering and for interfacing modern biology with engineering principles.
1992 - Fellow of the Indian National Academy of Engineering (INAE)
1989 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Douglas A. Lauffenburger is a researcher affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their work spans multiple scientific disciplines including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

Lauffenburger has contributed extensively to subfields such as Infectious Diseases, Immunology, Molecular Biology, Epidemiology, and Oncology. Their research focus includes topics related to SARS-CoV-2 and COVID-19, COVID-19 clinical research studies, monoclonal and polyclonal antibodies research, immunotherapy and immune responses, single-cell and spatial transcriptomics, immune cell function and interaction, and tuberculosis research and epidemiology.

Among recent published papers are:

Correlates of protection against SARS-CoV-2 in rhesus macaques, 2020, Nature
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques, 2020, Nature
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival, 2020, Immunity
Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data, 2020, Genome Biology
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality, 2020, Cell

Frequent co-authors working with Douglas A. Lauffenburger include:

Galit Alter
Caroline Atyeo
Stephanie Fischinger
Carolin Loos
Dan H. Barouch

The venues where Lauffenburger has frequently published include:

bioRxiv (Cold Spring Harbor Laboratory)
SSRN Electronic Journal
Cell
Science Translational Medicine
Nature Communications

Throughout their career, Lauffenburger has been recognized with several honors such as:

Fellow of the American Association for the Advancement of Science (AAAS) in 2019
Member of the National Academy of Engineering in 2001 for contributions in molecular and cellular engineering and for interfacing modern biology with engineering principles
Fellow of the American Academy of Arts and Sciences in 2001
Fellow of the Indian National Academy of Engineering (INAE) in 1992
Fellow of John Simon Guggenheim Memorial Foundation in 1989

Best Publications

Cell Migration: A Physically Integrated Molecular Process

Douglas A Lauffenburger;Alan F Horwitz

5166
Citations
Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data

Karen Sachs;Karen Sachs;Karen Sachs;Omar Perez;Omar Perez;Omar Perez;Dana Pe'er;Dana Pe'er;Dana Pe'er;Douglas A. Lauffenburger;Douglas A. Lauffenburger;Douglas A. Lauffenburger

2004
Citations
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

Sean P. Palecek;Joseph C. Loftus;Mark H. Ginsberg;Douglas A. Lauffenburger

1759
Citations
Receptors: Models for Binding, Trafficking, and Signaling

Douglas A Lauffenburger;Jennifer J Linderman

1420
Citations
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.

Muhammad H. Zaman;Linda M. Trapani;Alisha L. Sieminski;Drew MacKellar

1410
Citations
Cell adhesion and motility depend on nanoscale RGD clustering.

G. Maheshwari;G. Brown;D.A. Lauffenburger;A. Wells

1183
Citations
Mathematical model for the effects of adhesion and mechanics on cell migration speed

P.A. DiMilla;K. Barbee;D.A. Lauffenburger

780
Citations
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength.

PA DiMilla;JA Stone;JA Quinn;SM Albelda

772
Citations
Physicochemical modelling of cell signalling pathways

Bree B. Aldridge;Bree B. Aldridge;John M. Burke;Douglas A. Lauffenburger;Peter K. Sorger;Peter K. Sorger

759
Citations
Vector unpacking as a potential barrier for receptor‐mediated polyplex gene delivery

David V. Schaffer;Nick A. Fidelman;Nily Dan;Douglas A. Lauffenburger

666
Citations
A Functional Role for Antibodies in Tuberculosis

Lenette L. Lu;Lenette L. Lu;Amy W. Chung;Amy W. Chung;Tracy R. Rosebrock;Musie Ghebremichael

634
Citations
Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules

Yi Zhang;Alejandro Wolf-Yadlin;Phillip L. Ross;Darryl J. Pappin

628
Citations
A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis

Kevin A. Janes;John G. Albeck;Suzanne Gaudet;Peter K. Sorger

626
Citations
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

Alejandro Wolf-Yadlin;Sampsa Hautaniemi;Douglas A. Lauffenburger;Forest M. White

599
Citations
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus

Lily Y. Koo;Darrell J. Irvine;Anne M. Mayes;Douglas A. Lauffenburger

511
Citations
Microfluidic Shear Devices for Quantitative Analysis of Cell Adhesion

Hang Lu;Lily Y. Koo;Wechung M. Wang;Douglas A. Lauffenburger

503
Citations
Regulation of Cell Migration by the Calcium-dependent Protease Calpain

Anna Huttenlocher;Sean P. Palecek;Qin Lu;Wenli Zhang

494
Citations
Cutting to the chase: calpain proteases in cell motility

Angela Glading;Douglas A. Lauffenburger;Alan Wells

487
Citations
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.

William Wei-Lun Chen;Birgit Schoeberl;Paul J Jasper;Mario Niepel

485
Citations
Biological surface engineering: a simple system for cell pattern formation

Shuguang Zhang;Lin Yan;Michael Altman;Michael Lässle

472
Citations

Frequent Co-Authors

Linda G. Griffith MIT

Alan Wells University of Pittsburgh

Peter K. Sorger Harvard University

Galit Alter MIT

Julio Saez-Rodriguez Heidelberg University

Frank B. Gertler MIT

Kevin M. Haigis Harvard University

Michael T. Hemann MIT

Forest M. White MIT

H. Steven Wiley Pacific Northwest National Laboratory

External Links

Personal website of Douglas A. Lauffenburger

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