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Michael T. Hemann

Michael T. Hemann

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
21700
World Ranking
6911
National Ranking
3188

Overview

Michael T. Hemann is a researcher affiliated with MIT in the United States, specializing in fields related to biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields including molecular biology, oncology, cancer research, immunology, and genetics, reflecting a focus on complex biological mechanisms and disease processes.

Their research topics prominently include CAR-T cell therapy research, DNA repair mechanisms, CRISPR and genetic engineering, virus-based gene therapy research, cancer genomics and diagnostics, genomics and chromatin dynamics, and acute myeloid leukemia research. These areas highlight an emphasis on cancer biology, genetic editing technologies, and immune response mechanisms.

Several research papers exemplify the scope of Michael T. Hemann's contributions:

  • A microRNA polycistron as a potential human oncogene, 2020, UNC Libraries
  • The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning, 2020, Proceedings of the National Academy of Sciences
  • Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy, 2021, Nature Communications
  • Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer, 2021, Science Advances
  • Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains, 2022, Nature Biomedical Engineering

Frequent co-authorship indicates collaboration with several scientists, including Azucena Ramos, Daniel R. Goulet, Julia Fröse, Catherine Koch, and P Leclerc. These relationships suggest active engagement in collaborative research projects within their specialized fields.

Michael T. Hemann has published extensively in several venues, with a notable number of papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Nature Communications, Nature Biomedical Engineering, and Blood. These outlets are recognized platforms for disseminating research in biological and medical sciences.

Best Publications

  • A microRNA polycistron as a potential human oncogene

    Lin Xiang He;J. Michael Thomson;Michael T Hemann;Eva Hernando-Monge

  • Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

    Christine Mayr;Michael T. Hemann;David P. Bartel

  • The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

    Michael T. Hemann;Margaret A. Strong;Ling Yang Hao;Carol W. Greider

  • Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

    Eva Hernando;Zaher Nahlé;Zaher Nahlé;Gloria Juan;Elena Diaz-Rodriguez

  • Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

    Ross A Dickins;Michael T Hemann;Jack T Zilfou;David R Simpson

  • Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

    Michael T. Hemann;Anka Bric;Julie Teruya-Feldstein;Andreas Herbst

  • An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

    Michael T. Hemann;Jordan S. Fridman;Jack T. Zilfou;Eva Hernando

  • DNA damage-mediated induction of a chemoresistant niche.

    Luke A. Gilbert;Michael T. Hemann

  • A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

    Peter M Bruno;Yunpeng Liu;Ga Young Park;Junko Murai

  • The p53-Bcl-2 connection

    M T Hemann;S W Lowe

  • Topoisomerase levels determine chemotherapy response in vitro and in vivo

    Darren J. Burgess;Jason Doles;Lars Zender;Wen Xue

  • The combined status of ATM and p53 link tumor development with therapeutic response

    Hai Jiang;H. Christian Reinhardt;Jirina Bartkova;Johanna Tommiska

  • Wild-derived inbred mouse strains have short telomeres

    Michael T. Hemann;Carol W. Greider

  • Stage-specific sensitivity to p53 restoration during lung cancer progression

    David M. Feldser;Kamena K. Kostova;Monte Meier Winslow;Sarah E. Taylor

  • Error-prone translesion synthesis mediates acquired chemoresistance.

    Kun Xie;Jason Doles;Michael T. Hemann;Graham C. Walker

  • Suppression of tumorigenesis by the p53 target PUMA.

    Michael T. Hemann;Jack T. Zilfou;Zhen Zhao;Darren J. Burgess

  • Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

    Michael T. Hemann;Karl Lenhard Rudolph;Margaret A. Strong;Ronald A. DePinho

  • Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy

    Jason D. Doles;Trudy Oliver;Eleanor Ruth Cameron;Gerald Hsu

  • Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

    Anka Bric;Cornelius Miething;Carl Uli Bialucha;Claudio Scuoppo;Claudio Scuoppo

  • A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

    Junko Murai;Yves Pommier;Michael T Hemann;Peter Michael Bruno

Frequent Co-Authors

Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Daniel J. DeAngelo
Daniel J. DeAngelo Harvard University
Richard Stone
Richard Stone Harvard University
Luke A. Gilbert
Luke A. Gilbert University of California, San Francisco
Stephen J. Elledge
Stephen J. Elledge Harvard University

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