World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
100
Citations
72122
World Ranking
737
National Ranking
369

Medicine

D-Index
100
Citations
71971
World Ranking
8101
National Ranking
4201

Overview

Frank J. Slack is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research interests primarily span the fields of Biochemistry, Genetics, and Molecular Biology, with an emphasis on molecular biology, cancer research, oncology, pulmonary and respiratory medicine, and biomedical engineering.

The scientist's work covers several main topics including cancer-related molecular mechanisms research, microRNA in disease regulation, RNA research and splicing, RNA modifications and cancer, RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, and circular RNAs in diseases.

Frequent coauthors collaborating with Frank J. Slack include Jonathan D. Lee, Raman Bahal, Wen Cai Zhang, Maria Mavrikaki, and Ioannis S. Vlachos.

Publishing often in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Nature Communications, Cancers, and RNA, Frank J. Slack has contributed extensively to these journals.

Notable recent papers authored or coauthored by Frank J. Slack include:

  • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation, 2021, Molecular Cell
  • Challenges identifying efficacious miRNA therapeutics for cancer, 2020, Expert Opinion on Drug Discovery
  • MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic, 2021, Frontiers in Cell and Developmental Biology
  • Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo, 2020, Clinical Cancer Research
  • ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity, 2020, Oncogene

Best Publications

  • Oncomirs : microRNAs with a role in cancer

    Aurora Esquela-Kerscher;Frank J. Slack

  • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

    Reinhart Bj;Slack Fj;Slack Fj;Basson M;Pasquinelli Ae

  • RAS Is Regulated by the let-7 MicroRNA Family

    Steven M. Johnson;Helge Grosshans;Jaclyn Shingara;Mike Byrom

  • MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

    Rajesha Rupaimoole;Frank J. Slack

  • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

    Amy E. Pasquinelli;Brenda J. Reinhart;Frank Slack;Mark Q. Martindale

  • Small non-coding RNAs in animal development

    Giovanni Stefani;Frank J. Slack

  • The let-7 MicroRNA represses cell proliferation pathways in human cells

    Charles D. Johnson;Aurora Esquela-Kerscher;Giovanni Stefani;Mike Byrom

  • Non-coding RNA networks in cancer.

    Eleni Anastasiadou;Leni S. Jacob;Frank J. Slack

  • The let-7 family of microRNAs.

    Sarah Roush;Frank J. Slack

  • The Role of Non-coding RNAs in Oncology

    Frank J. Slack;Frank J. Slack;Arul M. Chinnaiyan

  • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

    Pedro P. Medina;Mona Nolde;Frank J. Slack

  • Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

    Mark B. Gerstein;Zhi John Lu;Eric L. Van Nostrand;Chao Cheng

  • MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

    Andrea L. Kasinski;Frank J. Slack

  • The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

    Frank J. Slack;Michael Basson;Zhongchi Liu;Victor R. Ambros

  • MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

    Christopher J. Cheng;Raman Bahal;Imran A. Babar;Zachary Pincus

  • A SNP in a let-7 microRNA Complementary Site in the KRAS 3′ Untranslated Region Increases Non–Small Cell Lung Cancer Risk

    Lena J. Chin;Elena Ratner;Shuguang Leng;Rihong Zhai

  • Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

    Phong Trang;Jason F Wiggins;Christopher L Daige;Chris Cho

  • The let-7 microRNA reduces tumor growth in mouse models of lung cancer.

    Aurora Esquela-Kerscher;Phong Trang;Jason F. Wiggins;Lubna Patrawala

  • OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer

    Alexander A. Svoronos;Donald M. Engelman;Frank J. Slack

  • let-7 microRNAs in development, stem cells and cancer.

    Ingo Büssing;Frank J. Slack;Helge Grosshans

Frequent Co-Authors

W. Mark Saltzman
W. Mark Saltzman Yale University
Hongyu Zhao
Hongyu Zhao Yale University
Gary Ruvkun
Gary Ruvkun Harvard University
Michael J. Kerin
Michael J. Kerin University of Galway
Abraham L. Sonenshein
Abraham L. Sonenshein Tufts University
Mark Gerstein
Mark Gerstein Yale University
Peter M. Glazer
Peter M. Glazer Yale University
Donald M. Engelman
Donald M. Engelman Yale University
Chao Cheng
Chao Cheng Baylor College of Medicine

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