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Genetics

D-Index
114
Citations
71562
World Ranking
460
National Ranking
237

Research.com Recognitions

  • 2015 - Breakthrough Prize in Life Sciences for the discovery of a new world of genetic regulation by microRNAs, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets.
  • 2014 - Gruber Prize in Genetics
  • 2012 - Dr. Paul Janssen Award for Biomedical Research, Johnson & Johnson for their collaborative discovery of microRNAs (miRNAs) as central regulators of gene expression and development.
  • 2009 - Louisa Gross Horwitz Prize, Columbia University
  • 2009 - Fellow of the American Academy of Arts and Sciences
  • 2009 - Member of the National Academy of Medicine (NAM)
  • 2008 - Member of the National Academy of Sciences
  • 2008 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2008 - Canada Gairdner International Award
  • 2008 - Benjamin Franklin Medal, Franklin Institute

Overview

Gary Ruvkun is affiliated with Harvard University in the United States and works primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research contributions span various subfields, including Molecular Biology, Aging, Astronomy and Astrophysics, Physiology, and Endocrine and Autonomic Systems.

The main topics of their research include:

  • Genetics, Aging, and Longevity in Model Organisms
  • Mitochondrial Function and Pathology
  • CRISPR and Genetic Engineering
  • RNA regulation and disease
  • Circadian rhythm and melatonin
  • Planetary Science and Exploration
  • Spaceflight effects on biology

Frequent co-authors in their work are Peter C. Breen, Kurt Warnhoff, Joshua D. Meisel, Presli P. Wiesenthal, and Vamsi K. Mootha.

Their work has been published in numerous scientific venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • PLoS Biology
  • PubMed
  • Nucleic Acids Research

Recent publications demonstrate their continued engagement with molecular genetics and related regulatory mechanisms. Examples include:

  • Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons, 2020, Proceedings of the National Academy of Sciences
  • Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism, 2020, Proceedings of the National Academy of Sciences
  • Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility, 2021, Nucleic Acids Research
  • Regulation and Functions of the ER-Associated Nrf1 Transcription Factor, 2022, Cold Spring Harbor Perspectives in Biology
  • Biological safety in the context of backward planetary protection and Mars Sample Return: conclusions from the Sterilization Working Group, 2021, International Journal of Astrobiology

Gary Ruvkun has received several awards and recognitions over the years, including the Breakthrough Prize in Life Sciences (2015) for discoveries related to microRNAs, the Gruber Prize in Genetics (2014), and the Dr. Paul Janssen Award for Biomedical Research from Johnson & Johnson (2012). They are also a member of both the National Academy of Medicine and the National Academy of Sciences, in addition to being a fellow of the American Academy of Arts and Sciences.

Other honors include the Louisa Gross Horwitz Prize, the Canada Gairdner International Award, the Albert Lasker Award for Basic Medical Research, and the Benjamin Franklin Medal by the Franklin Institute, all awarded between 2008 and 2009.

Best Publications

  • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

    Reinhart Bj;Slack Fj;Slack Fj;Basson M;Pasquinelli Ae

  • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

    Bruce Wightman;Ilho Ha;Gary Ruvkun

  • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

    Amy E. Pasquinelli;Brenda J. Reinhart;Frank Slack;Mark Q. Martindale

  • daf-2, an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

    Koutarou D. Kimura;Heidi A. Tissenbaum;Yanxia Liu;Gary Ruvkun

  • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

    Alla Grishok;Amy E. Pasquinelli;Darryl Conte Jr.;Na Li

  • A uniform system for microRNA annotation

    Victor R. Ambros;Bonnie Bartel;David P. Bartel;Christopher B. Burge

  • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

    Scott Ogg;Suzanne Paradis;Shoshanna Gottlieb;Garth I. Patterson

  • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

    Kaveh Ashrafi;Francesca Y. Chang;Jennifer L. Watts;Andrew G. Fraser

  • Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis

    H M Meade;S R Long;G B Ruvkun;S E Brown

  • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

    Jason Z. Morris;Heidi A. Tissenbaum;Gary Ruvkun

  • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.

    Siu Sylvia Lee;Raymond Y. N. Lee;Raymond Y. N. Lee;Andrew G. Fraser;Ravi S. Kamath

  • The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

    Frank J. Slack;Michael Basson;Zhongchi Liu;Victor R. Ambros

  • The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

    W Herr;R A Sturm;R G Clerc;L M Corcoran

  • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

    Suzanne Paradis;Gary Ruvkun

  • Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

    Catherine A. Wolkow;Koutarou D. Kimura;Ming-Sum Lee;Gary Ruvkun

  • A general method for site-directed mutagenesis in prokaryotes.

    Gary B. Ruvkun;Frederick M. Ausubel

  • DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

    Siu Sylvia Lee;Scott Kennedy;Scott Kennedy;Andrew C. Tolonen;Andrew C. Tolonen;Gary Ruvkun;Gary Ruvkun

  • Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

    John Kim;Anna Krichevsky;Yonatan Grad;Gabriel D. Hayes

  • Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

    Sarah B. Pierce;Michael Costa;Robert Wisotzkey;Sharmila Devadhar

  • A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

    Scott Kennedy;Duo Wang;Gary Ruvkun

Frequent Co-Authors

Frederick M. Ausubel
Frederick M. Ausubel Harvard University
Oliver Hobert
Oliver Hobert Columbia University
Frank J. Slack
Frank J. Slack Beth Israel Deaconess Medical Center
George M. Church
George M. Church Harvard University
Ronald H. A. Plasterk
Ronald H. A. Plasterk University of Amsterdam
James C. Carrington
James C. Carrington Donald Danforth Plant Science Center
Victor R. Ambros
Victor R. Ambros University of Massachusetts Chan Medical School
Annegien Broeks
Annegien Broeks Antoni van Leeuwenhoek Hospital
Georg Jander
Georg Jander Boyce Thompson Institute

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