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Genetics

D-Index
72
Citations
77524
World Ranking
2075
National Ranking
944

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2015 - Breakthrough Prize in Life Sciences for the discovery of a new world of genetic regulation by microRNAs, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets.
  • 2014 - Gruber Prize in Genetics
  • 2013 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 2012 - Dr. Paul Janssen Award for Biomedical Research, Johnson & Johnson for their collaborative discovery of microRNAs (miRNAs) as central regulators of gene expression and development.
  • 2011 - Fellow of the American Academy of Arts and Sciences
  • 2009 - Louisa Gross Horwitz Prize, Columbia University
  • 2008 - Canada Gairdner International Award
  • 2008 - Benjamin Franklin Medal, Franklin Institute
  • 2008 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2007 - Member of the National Academy of Sciences
  • 2006 - Genetics Society of America Medal

Overview

Victor R. Ambros is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to the subfields of molecular biology, cancer research, aging, materials chemistry, and endocrinology.

The scientist's work extensively covers several key topics including microRNA in disease regulation, genetics, aging, and longevity in model organisms, CRISPR and genetic engineering, RNA research and splicing, circular RNAs in diseases, RNA interference and gene delivery, as well as RNA and protein synthesis mechanisms.

Recent publications highlight diverse research areas spanning molecular biology and genetics, including:

  • Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides, 2020, Proceedings of the National Academy of Sciences
  • Critical contribution of 3' non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA, 2022, Cell Reports
  • A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans, 2023, Cell Reports
  • Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes, 2020, PLoS Biology
  • Modeling neurodevelopmental disorder-associated human AGO1 mutations in Caenorhabditis elegans Argonaute alg-1, 2024, Proceedings of the National Academy of Sciences

Victor R. Ambros has collaborated frequently with several scientists, including:

  • Ye Duan
  • Charles Nelson
  • Isana Veksler-Lublinsky
  • Ganesh Panzade
  • Amélie Piton

Their work has been published in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Proceedings of the National Academy of Sciences, PubMed, and Postępy Biochemii.

Victor R. Ambros has received multiple awards throughout their career. These include the Fellowship of the American Association for the Advancement of Science (2018), the Breakthrough Prize in Life Sciences (2015) for discoveries in genetic regulation by microRNAs, the Gruber Prize in Genetics (2014), the Keio Medical Science Prize (2013), and the Dr. Paul Janssen Award for Biomedical Research presented by Johnson & Johnson (2012) for collaborative discoveries related to microRNAs.

Additional recognitions comprise Fellowship of the American Academy of Arts and Sciences (2011), the Louisa Gross Horwitz Prize from Columbia University (2009), the Canada Gairdner International Award (2008), the Benjamin Franklin Medal (2008), the Albert Lasker Award for Basic Medical Research (2008), membership in the National Academy of Sciences (2007), and the Genetics Society of America Medal (2006).

Best Publications

  • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

    Rosalind C. Lee;Rhonda L. Feinbaum;Victor R. Ambros

  • The functions of animal microRNAs

    Victor R. Ambros

  • Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

    Craig C. Mello;James M. Kramer;Dan Stinchcomb;Victor Ambros

  • An Extensive Class of Small RNAs in Caenorhabditis elegans

    Rosalind C. Lee;Victor R. Ambros

  • A uniform system for microRNA annotation

    Victor R. Ambros;Bonnie Bartel;David P. Bartel;Christopher B. Burge

  • microRNAs: Tiny Regulators with Great Potential

    Victor R. Ambros

  • Role of MicroRNAs in Plant and Animal Development

    James C. Carrington;Victor Ambros

  • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

    Lorenzo F. Sempere;Sarah J Freemantle;Ian Pitha-Rowe;Eric Moss

  • MicroRNA Pathways in Flies and Worms: Growth, Death, Fat, Stress, and Timing

    Victor R. Ambros

  • The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

    Philip H. Olsen;Victor R. Ambros

  • The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA

    Eric G. Moss;Rosalind C. Lee;Victor R. Ambros

  • Heterochronic mutants of the nematode Caenorhabditis elegans

    V Ambros;HR Horvitz

  • The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

    Frank J. Slack;Michael Basson;Zhongchi Liu;Victor R. Ambros

  • MicroRNAs and other tiny endogenous RNAs in C. elegans

    Victor R. Ambros;Rosalind C. Lee;Ann Lavanway;Peter T. Williams

  • Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines

    Arti Gaur;David A. Jewell;Yu Liang;Dana Ridzon

  • The let-7 MicroRNA Family Members mir -48, mir -84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

    Allison L. Abbott;Ezequiel Alvarez-Saavedra;Eric A. Miska;Nelson C. Lau

  • Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability

    Eric Alexander Miska;Ezequiel Alvarez-Saavedra;Allison L Abbott;Nelson C Lau

  • Potent effect of target structure on microRNA function.

    Dang Long;Rosalind Lee;Peter Williams;Chi Yu Chan

  • Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth

    Nicholas S. Sokol;Victor R. Ambros

  • A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans

    Victor R. Ambros

Frequent Co-Authors

David Baltimore
David Baltimore California Institute of Technology
Jane E. Freedman
Jane E. Freedman Vanderbilt University Medical Center
Zhongchi Liu
Zhongchi Liu University of Maryland, College Park
Gary Ruvkun
Gary Ruvkun Harvard University
Frederick M. Ausubel
Frederick M. Ausubel Harvard University
John F. Keaney
John F. Keaney Brigham and Women's Hospital
Albertha J.M. Walhout
Albertha J.M. Walhout University of Massachusetts Chan Medical School
James C. Carrington
James C. Carrington Donald Danforth Plant Science Center

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