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Biology and Biochemistry
China
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
99
Citations
37951
World Ranking
1579
National Ranking
36

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Ke Zen is affiliated with Nanjing University in China and has contributed extensively to research in Biochemistry, Genetics, and Molecular Biology, with a significant focus on Medicine. Their work spans multiple subfields including Molecular Biology, Cancer Research, Immunology, Nephrology, and Physiology.

The scientist's recent peer-reviewed publications demonstrate a focus on molecular and cellular mechanisms underlying disease processes. Notable papers include:

  • "Sodium-glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice" (2020) published in Cell Death and Disease
  • "SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs" (2020) published in Cell Research
  • "Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration" (2021) published in Nature Communications
  • "Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell" (2022) published in Stem Cell Research & Therapy
  • "PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling" (2021) published in Genome Medicine

Ke Zen frequently collaborates with a core group of researchers, including Shuang Qu, Hongwei Liang, Zhihong Liu, Mingchao Zhang, and Bing Yao, demonstrating consistent partnerships contributing to various projects and publications.

The scientist's work appears regularly in high-impact journals and publication venues such as Cell Death and Disease, Nature Communications, Advanced Science, SSRN Electronic Journal, and Cell Research.

Research topics explored by Ke Zen encompass:

  • Extracellular vesicles in disease
  • RNA modifications and cancer
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Renal Diseases and Glomerulopathies
  • RNA Interference and Gene Delivery
  • Cancer-related gene regulation

These topics align with their publication record and subfields of study, indicating a strong emphasis on mechanisms of disease at the molecular and cellular levels, particularly with respect to cancer biology and renal diseases.

Best Publications

  • Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

    Xi Chen;Yi Ba;Lijia Ma;Lijia Ma;Xing Cai

  • Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

    Nan Wang;Hongwei Liang;Ke Zen

  • Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

    Yujing Zhang;Danqing Liu;Xi Chen;Jing Li

  • Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA

    Lin Zhang;Dongxia Hou;Xi Chen;Donghai Li

  • Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer

    Zhibin Hu;Xi Chen;Yang Zhao;Tian Tian

  • Secreted microRNAs: a new form of intercellular communication.

    Xi Chen;Hongwei Liang;Junfeng Zhang;Ke Zen

  • Role of miR-143 targeting KRAS in colorectal tumorigenesis

    X. Chen;X. Guo;H. Zhang;H. Zhang;Y. Xiang

  • Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers.

    Ke Zen;Chen-Yu Zhang

  • Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma

    Li-Min Li;Zhi-Bin Hu;Zhen-Xian Zhou;Xi Chen

  • A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis

    Rui Liu;Chunni Zhang;Zhibin Hu;Gou Li;Gou Li

  • Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

    Zhen Zhou;Xihan Li;Jinxiong Liu;Lei Dong

  • Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products.

    Xi Chen;Chao Gao;Haijin Li;Lei Huang

  • Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer

    Rui Liu;Rui Liu;Xi Chen;Xi Chen;Yiqi Du;Weiyan Yao

  • Expression Profile of MicroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma

    Chunni Zhang;Cheng Wang;Xi Chen;Cuihua Yang

  • Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis

    Xi Chen;Zhibin Hu;Wenjing Wang;Yi Ba

  • Horizontal transfer of microRNAs: molecular mechanisms and clinical applications

    Xi Chen;Hongwei Liang;Junfeng Zhang;Ke Zen

  • Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

    Xing Cai;Yuan Yin;Ningzhu Li;Dihan Zhu

  • Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse.

    Yuchen Liu;Dameng Li;Zhengya Liu;Yu Zhou

  • Altered Profile of Seminal Plasma MicroRNAs in the Molecular Diagnosis of Male Infertility

    Cheng Wang;Cuihua Yang;Xi Chen;Bing Yao

  • Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.

    Yao Wei;Dong Wang;Fangfang Jin;Zhen Bian

Frequent Co-Authors

Chen-Yu Zhang
Chen-Yu Zhang Nanjing University
Xi Chen
Xi Chen Nanjing University
Cheng Wang
Cheng Wang University of Massachusetts Dartmouth
Yi Ba
Yi Ba Beijing Institute of Genomics
Zhihong Liu
Zhihong Liu Nanjing University
Lei Jiang
Lei Jiang Chinese Academy of Sciences
Hongwei Gu
Hongwei Gu Soochow University
Charles A. Parkos
Charles A. Parkos University of Michigan–Ann Arbor
Dong Wang
Dong Wang Peking University
Lei Huang
Lei Huang Sichuan University

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