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Immunology

D-Index
78
Citations
21083
World Ranking
1757
National Ranking
153

Overview

Lucy R. Wedderburn is affiliated with University College London in the United Kingdom. Their main field of study is Medicine, with a focus on several subfields including Hematology, Epidemiology, Immunology, Rheumatology, and Infectious Diseases.

The scientist's research explores a range of topics, notably autoimmune and inflammatory disorders, inflammatory myopathies and dermatomyositis, adolescent and pediatric healthcare, immunodeficiency and autoimmune disorders, acute lymphoblastic leukemia, COVID-19 clinical research studies, and celiac disease research and management.

Recent significant publications include:

  • Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission, 2020, Nature Communications
  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans, 2020, Science
  • Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells, 2020, Cell Metabolism
  • Biological classification of childhood arthritis: roadmap to a molecular nomenclature, 2021, Nature Reviews Rheumatology
  • Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells, 2020, Immunity

Frequent co-authors collaborating with Wedderburn include:

  • Kimme L Hyrich
  • Coziana Ciurtin
  • Elizabeth C. Rosser
  • Melissa Kartawinata
  • Claire T. Deakin

Their work is often published in venues such as:

  • Lara D. Veeken
  • Annals of the Rheumatic Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Rheumatology Advances in Practice
  • Nature Reviews Rheumatology

Best Publications

  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

    Kevin W. Ng;Nikhil Faulkner;Georgina H. Cornish;Annachiara Rosa

  • CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

    Ismé M. de Kleer;Lucy R. Wedderburn;Leonie S. Taams;Alka Patel

  • Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

    Elizabeth C. Rosser;Elizabeth C. Rosser;Christopher J.M. Piper;Diana E. Matei;Paul A. Blair

  • Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.

    Kiran Nistala;Stuart Adams;Helen Cambrook;Simona Ursu

  • Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

    Anne Hinks;Anne Hinks;Joanna E. Cobb;Joanna E. Cobb;Miranda C. Marion;Sampath Prahalad

  • Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.

    Kiran Nistala;Halima Moncrieffe;Katy R Newton;Hemlata Varsani

  • Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study

    Wilco de Jager;Esther P A H Hoppenreijs;Nico M Wulffraat;Lucy R Wedderburn

  • The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland)—clinical characteristics of children recruited within the first 5 yr

    L J McCann;A D Juggins;S M Maillard;L R Wedderburn

  • T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria.

    Hilton C. Whittle;Jim Brown;Kevin Marsh;Brian M. Greenwood

  • Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis

    Kiran Nistala;Lucy R Wedderburn

  • Autoantibodies to a 140‐kd protein in juvenile dermatomyositis are associated with calcinosis

    Harsha Gunawardena;L R Wedderburn;H Chinoy;Zoe E Betteridge

  • Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis

    S M Maillard;R Jones;C Owens;C Pilkington

  • Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis.

    Lucy R. Wedderburn;Nicola Robinson;Alka Patel;Hemlata Varsani

  • Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis.

    H. Gunawardena;L. R. Wedderburn;J. North;Z. Betteridge

  • Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis

    A T Chan;S D Kollnberger;L R Wedderburn;P Bowness

  • Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study

    Sarah L Tansley;Zoe E Betteridge;Harsha Gunawardena;Thomas S Jacques

  • The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis

    Dirk Holzinger;Michael Frosch;Astrid Kastrup;Femke H M Prince

  • Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort.

    Sarah L. Tansley;Sarah L. Tansley;Stefania Simou;Gavin Shaddick;Zoe E. Betteridge

  • HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

    Michael J. Ombrello;Elaine F. Remmers;Ioanna Tachmazidou;Alexei Grom;Alexei Grom

  • Structural and Functional Insights of RANKL–RANK Interaction and Signaling

    Changzhen Liu;Thomas S. Walter;Peng Huang;Shiqian Zhang

  • Clonal Expansions in Acute EBV Infection Are Detectable in the CD8 and not the CD4 Subset and Persist with a Variable CD45 Phenotype

    Mala K. Maini;Nancy Gudgeon;Lucy R. Wedderburn;Alan B. Rickinson

  • Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

    Kevin Ng;Nikhil Faulkner;Georgina Cornish;Annachiara Rosa

Frequent Co-Authors

Wendy Thomson
Wendy Thomson University of Manchester
Kimme L. Hyrich
Kimme L. Hyrich University of Manchester
Neil McHugh
Neil McHugh University of Bath
Anne Hinks
Anne Hinks University of Manchester
Janice L. Holton
Janice L. Holton University College London
Susan D. Thompson
Susan D. Thompson Cincinnati Children's Hospital Medical Center
Ingrid E. Lundberg
Ingrid E. Lundberg Karolinska University Hospital
Janine A. Lamb
Janine A. Lamb University of Manchester
John F. Bohnsack
John F. Bohnsack University of Utah
Carl D. Langefeld
Carl D. Langefeld Wake Forest University

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