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Genetics

D-Index
74
Citations
62996
World Ranking
1922
National Ranking
880

Research.com Recognitions

  • 2012 - Fellow, National Academy of Inventors
  • 2008 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Nobel Prize for their discovery of RNA interference - gene silencing by double-stranded RNA
  • 2005 - Member of the National Academy of Sciences

Overview

Craig C. Mello is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Aging, Plant Science, Genetics, and Virology. The main topics of their work include Genetics, Aging, and Longevity in Model Organisms; CRISPR and Genetic Engineering; RNA Research and Splicing; Chromosomal and Genetic Variations; Genomics and Chromatin Dynamics; Ubiquitin and proteasome pathways; and Evolution and Genetic Dynamics.

Among the recent papers associated with this research domain are:

  • Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans, 2020, Genetics
  • Microinjection for precision genome editing in Caenorhabditis elegans, 2021, STAR Protocols
  • 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing, 2021, eLife
  • Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility, 2021, Nature Communications
  • HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans, 2021, eLife

Frequent coauthors include:

  • Yue-He Ding
  • Takao Ishidate
  • Meng-Qiu Dong
  • Darryl Conte
  • Krishna S. Ghanta

Publications are often featured in venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Nature Communications, Cell Reports, and Genetics.

Craig C. Mello has been recognized with several awards throughout their career, including the Nobel Prize in 2006 for the discovery of RNA interference-gene silencing by double-stranded RNA. In addition, they were named a Fellow of the American Academy of Arts and Sciences in 2008, became a Member of the National Academy of Sciences in 2005, and a Fellow of the National Academy of Inventors in 2012.

Best Publications

  • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

    Andrew Fire;SiQun Xu;Mary K. Montgomery;Steven A. Kostas;Steven A. Kostas

  • Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

    Craig C. Mello;James M. Kramer;Dan Stinchcomb;Victor Ambros

  • Genetic inhibition of double-stranded RNA

    Andrew Z. Fire;Stephen A. Kostas;Mary K. Montgomery;Lisa Timmons

  • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

    Alla Grishok;Amy E. Pasquinelli;Darryl Conte Jr.;Na Li

  • The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

    Hiroaki Tabara;Madathia Sarkissian;William G. Kelly;Jamie Fleenor

  • Chapter 19 DNA Transformation

    Craig Mello;Andrew Fire

  • Revealing the world of RNA interference

    Craig C. Mello;Darryl Conte

  • Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

    Upasna Sharma;Colin C. Conine;Jeremy M. Shea;Ana Boskovic

  • RNAi in C. elegans: Soaking in the Genome Sequence

    Hiroaki Tabara;Alla Grishok;Craig C. Mello

  • Functional Anatomy of a dsRNA Trigger: Differential Requirement for the Two Trigger Strands in RNA Interference

    Susan Parrish;Jamie Fleenor;SiQun Xu;Craig Mello

  • Sequence-specific inhibition of small RNA function

    Gyorgy Hutvagner;Phillip D. Zamore

  • Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

    Christian E. Rocheleau;William D. Downs;William D. Downs;Rueyling Lin;Rueyling Lin;Claudia Wittmann

  • Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi

    Erbay Yigit;Pedro J. Batista;Yanxia Bei;Ka Ming Pang

  • Genetic Requirements for Inheritance of RNAi in C. elegans

    Alla Grishok;Hiroaki Tabara;Craig C. Mello

  • The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

    Hiroaki Tabara;Erbay Yigit;Haruhiko Siomi;Craig C. Mello

  • PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.

    Pedro J. Batista;J. Graham Ruby;Julie M. Claycomb;H. Rosaria Chiang

  • piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

    Masaki Shirayama;Meetu Seth;Heng-Chi Lee;Weifeng Gu

  • Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.

    Weifeng Gu;Masaki Shirayama;Darryl Conte Jr.;Jessica Vasale

  • Rna interference pathway genes as tools for targeted genetic interference

    Craig C. Mello;Andrew Fire;Hiroaki Tabara;Alla Grishok

  • The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

    Julie M. Claycomb;Pedro J. Batista;Ka Ming Pang;Weifeng Gu

Frequent Co-Authors

James R. Priess
James R. Priess University of Washington
Andrew Fire
Andrew Fire Stanford University
John R. Yates
John R. Yates Scripps Research Institute
Phillip D. Zamore
Phillip D. Zamore University of Massachusetts Chan Medical School
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School
Dirk G. de Rooij
Dirk G. de Rooij Utrecht University
Shohei Mitani
Shohei Mitani Tokyo Women's Medical University
Meng-Qiu Dong
Meng-Qiu Dong Tsinghua University
Gregory J. Hannon
Gregory J. Hannon University of Cambridge

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