World's Best Scientists 2026 revealed!
W. Mark Saltzman

W. Mark Saltzman

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
33171
World Ranking
1467
National Ranking
835

Research.com Recognitions

  • 2018 - Member of the National Academy of Engineering For contributions in drug delivery, biomaterials, and tissue engineering that have led to improved patient treatments.
  • 2014 - Member of the National Academy of Medicine (NAM)
  • 2013 - Fellow, National Academy of Inventors
  • 1997 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

W. Mark Saltzman is affiliated with Yale University in the United States, with a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work primarily addresses molecular biology and biomaterials, with additional contributions in genetics, pulmonary and respiratory medicine, and surgery.

The scientist's research topics include RNA interference and gene delivery, nanoparticle-based drug delivery, advanced biosensing and bioanalysis techniques, CRISPR and genetic engineering, virus-based gene therapy research, glioma diagnosis and treatment, and nanoplatforms for cancer theranostics.

Recent publications illustrate a focus on vaccine development, nucleic acid delivery systems, and therapeutic approaches for gliomas. Examples include:

  • "Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses" (2022, Science)
  • "Polymeric vehicles for nucleic acid delivery" (2020, Advanced Drug Delivery Reviews)
  • "Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance" (2021, Nature Biomedical Engineering)
  • "Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination" (2023, Science Translational Medicine)
  • "The NIH Somatic Cell Genome Editing program" (2021, Nature)

There are frequent collaborations with several researchers, notably Alexandra S. Piotrowski-Daspit, Peter M. Glazer, Hee-Won Suh, Ranjit S. Bindra, and Elias Quijano.

Saltzman has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Cystic Fibrosis, Bioengineering & Translational Medicine, Cancer Research, and Biomaterials.

Their accolades include membership in the National Academy of Engineering (2018) for contributions related to drug delivery, biomaterials, and tissue engineering, as well as memberships and fellowships in the National Academy of Medicine (2014), National Academy of Inventors (2013), and the Indian National Academy of Engineering (1997).

Best Publications

  • MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

    Christopher J. Cheng;Raman Bahal;Imran A. Babar;Zachary Pincus

  • Selective cell transplantation using bioabsorbable artificial polymers as matrices.

    Joseph P. Vacanti;Martin A. Morse;W. Mark Saltzman;Abraham J. Domb

  • Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling

    Jason D. Roh;Rajendra Sawh-Martinez;Matthew P. Brennan;Steven M. Jay

  • Polymeric nanoparticles for drug delivery to the central nervous system

    Toral Patel;Jiangbing Zhou;Joseph M. Piepmeier;W. Mark Saltzman

  • Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

    Imran A. Babar;Christopher J. Cheng;Carmen J. Booth;Xianping Liang

  • Drug Delivery: Engineering Principles for Drug Therapy

    W. Mark Saltzman

  • Poly(ethylene glycol)-Conjugated PAMAM Dendrimer for Biocompatible, High-Efficiency DNA Delivery

    Dan Luo;Kraig Haverstick;Nadya Belcheva;Ernest Han

  • Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA.

    Kim A. Woodrow;Yen Cu;Carmen J. Booth;Jennifer K. Saucier-Sawyer

  • The uptake and intracellular fate of PLGA nanoparticles in epithelial cells.

    Malgorzata S. Cartiera;Katherine M. Johnson;Vanathy Rajendran;Michael J. Caplan

  • A holistic approach to targeting disease with polymeric nanoparticles

    Christopher J. Cheng;Gregory T. Tietjen;Jennifer K. Saucier-Sawyer;W. Mark Saltzman

  • Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles

    Hong Shen;Anne L. Ackerman;Virginia Cody;Alessandra Giodini

  • PEGylated PLGA nanoparticles for the improved delivery of doxorubicin

    Jason Park;Peter M. Fong;Jing Lu;Kerry S. Russell

  • Pharmacokinetics of Interstitial Delivery of Carmustine, 4-Hydroperoxycyclophosphamide, and Paclitaxel from a Biodegradable Polymer Implant in the Monkey Brain

    Lawrence K. Fung;Matthew G. Ewend;Allen Sills;Eric P. Sipos

  • Building drug delivery into tissue engineering design

    W. Mark Saltzman;William L. Olbricht

  • Biodegradable poly(amine- co -ester) terpolymers for targeted gene delivery

    Jiangbing Zhou;Jie Liu;Christopher J. Cheng;Toral R. Patel

  • Therapeutic siRNA: principles, challenges, and strategies.

    Kseniya Gavrilov;W Mark Saltzman

  • Controlled release of dopamine from a polymeric brain implant: In vivo characterization

    Matthew J. During;Matthew J. During;Andrew Freese;Bernhard A. Sabel;W. Mark Saltzman;W. Mark Saltzman

  • Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy.

    Stacey L. Demento;Stephanie C. Eisenbarth;Harald G. Foellmer;Craig Platt

  • Materials for protein delivery in tissue engineering.

    Samuel P Baldwin;W Mark Saltzman

  • Pharmacokinetics of the Carmustine Implant

    Alison B. Fleming;W. Mark Saltzman

Frequent Co-Authors

Jordan S. Pober
Jordan S. Pober Yale University
Peter M. Glazer
Peter M. Glazer Yale University
Themis R. Kyriakides
Themis R. Kyriakides Yale University
Frank J. Slack
Frank J. Slack Beth Israel Deaconess Medical Center
Michael J. Caplan
Michael J. Caplan Yale University
Donald M. Engelman
Donald M. Engelman Yale University
Alessandro D. Santin
Alessandro D. Santin Yale University
Christopher K. Ober
Christopher K. Ober Cornell University
Federica Chiellini
Federica Chiellini University of Pisa

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