World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
120
Citations
54084
World Ranking
378
National Ranking
191

Medicine

D-Index
123
Citations
56693
World Ranking
3352
National Ranking
1843

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - Fellow of the American Statistical Association (ASA)

Overview

Hongyu Zhao is a researcher affiliated with Yale University in the United States. Their work spans multiple fields, primarily focusing on Biochemistry, Genetics, and Molecular Biology, with substantial contributions to Medicine.

Their research covers several subfields including:

  • Molecular Biology
  • Genetics
  • Immunology
  • Artificial Intelligence
  • Epidemiology

Key topics in Zhao's work involve:

  • Genetic Associations and Epidemiology
  • Single-cell and spatial transcriptomics
  • Gene expression and cancer classification
  • Genetic Mapping and Diversity in Plants and Animals
  • Genetic and phenotypic traits in livestock
  • Bioinformatics and Genomic Networks
  • Epigenetics and DNA Methylation

Zhao has published extensively, with notable recent papers including:

  • "Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors" (2020, Nature Medicine)
  • "A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response" (2021, Science Immunology)
  • "Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men" (2020, Cell stem cell)
  • "Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program" (2021, Nature Genetics)
  • "Genotyping Array Design and Data Quality Control in the Million Veteran Program" (2020, The American Journal of Human Genetics)

Zhao frequently collaborates with other researchers, including:

  • Yixuan Ye
  • Wei Jiang
  • Jianlei Gu
  • Saiju Pyarajan
  • Jiawei Wang

They have published in a variety of venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Nature Communications
  • arXiv (Cornell University)
  • Research Square (Research Square)

In addition to articles, Zhao has contributed to academic books, with a publication titled Handbook of Statistical Bioinformatics published by Springer International Publishing in 2022.

Their professional recognition includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 and a Fellow of the American Statistical Association (ASA) in 2006.

Best Publications

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

    Luke Jostins;Stephan Ripke;Rinse K Weersma;Richard H Duerr

  • Analysis of Transcription Factor HY5 Genomic Binding Sites Revealed Its Hierarchical Role in Light Regulation of Development

    Jungeun Lee;Jungeun Lee;Kun He;Viktor Stolc;Viktor Stolc;Horim Lee

  • Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project)

    Jiapeng Lu;Yuan Lu;Xiaochen Wang;Xinyue Li

  • De novo mutations in histone-modifying genes in congenital heart disease

    Samir Zaidi;Murim Choi;Hiroko Wakimoto;Lijiang Ma

  • Rare independent mutations in renal salt handling genes contribute to blood pressure variation

    Weizhen Ji;Jia Nee Foo;Brian J O'Roak;Hongyu Zhao

  • Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

    Sheng Chih Jin;Jason Homsy;Samir Zaidi;Qiongshi Lu

  • Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

    Raymond K. Walters;Raymond K. Walters;Renato Polimanti;Emma C. Johnson;Jeanette N. McClintick

  • Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

    Alexander G Bick;Joshua S Weinstock;Satish K Nandakumar;Satish K Nandakumar;Charles P Fulco;Charles P Fulco

  • Light Control of Arabidopsis Development Entails Coordinated Regulation of Genome Expression and Cellular Pathways

    Ligeng Ma;Ligeng Ma;Jinming Li;Lijia Qu;Janet Hager

  • Serum protein markers for early detection of ovarian cancer

    Gil Mor;Irene Visintin;Yinglei Lai;Hongyu Zhao

  • International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

    Caroline M. Nievergelt;Caroline M. Nievergelt;Adam X. Maihofer;Adam X. Maihofer;Torsten Klengel;Torsten Klengel;Elizabeth G. Atkinson;Elizabeth G. Atkinson

  • Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data

    Baolin Wu;Tom Abbott;David Fishman;Walter McMurray

  • Direct interaction of Arabidopsis cryptochromes with COP1 in light control development.

    Haiyang Wang;Li-Geng Ma;Li-Geng Ma;Jin-Ming Li;Hong-Yu Zhao

  • Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.

    Keith S Hoek;David L Rimm;Kenneth R Williams;Hongyu Zhao

  • Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

    Zhongyu Xie;Di Zhang;Dongjun Chung;Dongjun Chung;Zhanyun Tang

  • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

    L. E. Duncan;A. Ratanatharathorn;A. E. Aiello;L. M. Almli

  • Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

    Yan Gao;Simone A. Nish;Ruoyi Jiang;Lin Hou

  • Next-generation sequencing in liquid biopsy: cancer screening and early detection.

    Ming Chen;Hongyu Zhao

  • An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

    Catherine A. Brownstein;Alan H. Beggs;Nils Homer;Barry Merriman

  • Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

    Henry R. Kranzler;Henry R. Kranzler;Hang Zhou;Hang Zhou;Rachel L. Kember;Rachel L. Kember;Rachel Vickers Smith;Rachel Vickers Smith

Frequent Co-Authors

Joel Gelernter
Joel Gelernter Yale University
Henry R. Kranzler
Henry R. Kranzler University of Pennsylvania
Lindsay A. Farrer
Lindsay A. Farrer Boston University
John Concato
John Concato Yale University
Murray B. Stein
Murray B. Stein University of California, San Diego
Kei-Hoi Cheung
Kei-Hoi Cheung Yale University
Amy C. Justice
Amy C. Justice Yale University
Xing Wang Deng
Xing Wang Deng Peking University
Richard P. Lifton
Richard P. Lifton Rockefeller University
Shrikant Mane
Shrikant Mane Yale University

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