World's Best Scientists 2026 revealed!
Stephen J. Lippard

Stephen J. Lippard

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Best Scientists
2025
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Chemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
167
Citations
128442
World Ranking
962
National Ranking
570

Chemistry

D-Index
166
Citations
128167
World Ranking
76
National Ranking
42

Research.com Recognitions

  • 2026 - Research.com Chemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Chemistry in United States Leader Award
  • 2016 - F.A. Cotton Medal for Excellence in Chemical Research, American Chemical Society (ACS)
  • 2016 - Welch Award in Chemistry, Robert A. Welch Foundation
  • 2014 - Priestley Medal, American Chemical Society (ACS)
  • 2011 - Fellow of the American Chemical Society
  • 2010 - Centenary Prize, Royal Society of Chemistry (UK)
  • 2009 - Linus Pauling Award, American Chemical Society (ACS)
  • 2004 - US President's National Medal of Science "For pioneering research in bioinorganic chemistry, which enriched our understanding of how metal compounds interact with DNA, provided important synthetic models for the active sites of metalloproteins, and elucidated key structural and mechanistic features of methane monooxygenase.", Presented by President George W. Bush in a White House East Room ceremony on February 13, 2006.
  • 2004 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Chemistry
  • 2002 - Member of the Royal Irish Academy
  • 1995 - William H. Nichols Medal, American Chemical Society (ACS)
  • 1993 - Member of the National Academy of Medicine (NAM)
  • 1989 - Member of the National Academy of Sciences
  • 1986 - Fellow of the American Academy of Arts and Sciences
  • 1981 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1971 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1968 - Fellow of Alfred P. Sloan Foundation
  • Member of the Norwegian Academy of Science and Letters Geoscience
  • Member of the Norwegian Academy of Science and Letters Geoscience
  • Member of the Norwegian Academy of Science and Letters Geoscience
  • Member of the Norwegian Academy of Science and Letters Geoscience
  • Member of the Norwegian Academy of Science and Letters Geoscience
  • Member of the Norwegian Academy of Science and Letters Geoscience

Overview

Stephen J. Lippard is affiliated with MIT in the United States. Their research spans several fields with a primary focus on Biochemistry, Genetics and Molecular Biology, Materials Science, and Medicine. Within these broad disciplines, subfields of study include Molecular Biology, Electronic, Optical and Magnetic Materials, Materials Chemistry, Oncology, and Cancer Research.

The scientist's work covers a range of topics reflecting diverse interests, notably:

  • Advanced biosensing and bioanalysis techniques
  • Nanocluster synthesis and applications
  • Gold and silver nanoparticles synthesis and applications
  • Molecular sensors and ion detection
  • Metal complexes synthesis and properties
  • Microtubule and mitosis dynamics
  • Cancer genomics and diagnostics

Their recent publications document active engagement in fields intersecting chemistry and biology. Selected recent papers include:

  • "Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division," 2020, Proceedings of the National Academy of Sciences
  • "Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints," 2020, Nature Communications
  • "HaloTag-Based Hybrid Targetable and Ratiometric Sensors for Intracellular Zinc," 2020, ACS Chemical Biology
  • "A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain," 2020, Journal of Medicinal Chemistry
  • "Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells," 2020, Journal of the American Chemical Society

Frequent publication venues for their work include Nature Communications, Proceedings of the National Academy of Sciences, ACS Chemical Biology, Journal of Medicinal Chemistry, and Journal of the American Chemical Society.

Collaborations are a notable aspect of their scientific activity, with frequent co-authors being Wen Zhou, Ömer Yılmaz, Jacob M. Goldberg, Shanta Dhar, and Weston L. Daniel.

Stephen J. Lippard has received numerous awards and honors from established institutions. These include:

  • Welch Award in Chemistry, Robert A. Welch Foundation, 2016
  • F.A. Cotton Medal for Excellence in Chemical Research, American Chemical Society (ACS), 2016
  • Priestley Medal, American Chemical Society (ACS), 2014
  • Fellow of the American Chemical Society, 2011
  • Centenary Prize, Royal Society of Chemistry (UK), 2010
  • Linus Pauling Award, American Chemical Society (ACS), 2009
  • German National Academy of Sciences Leopoldina, 2004, Chemistry
  • US President's National Medal of Science, 2004, "For pioneering research in bioinorganic chemistry, which enriched our understanding of how metal compounds interact with DNA, provided important synthetic models for the active sites of metalloproteins, and elucidated key structural and mechanistic features of methane monooxygenase."
  • Member of the Royal Irish Academy, 2002
  • William H. Nichols Medal, American Chemical Society (ACS), 1995
  • Member of the National Academy of Medicine (NAM), 1993
  • Member of the National Academy of Sciences, 1989
  • Fellow of the American Academy of Arts and Sciences, 1986
  • Fellow of the American Association for the Advancement of Science (AAAS), 1981
  • Fellow of John Simon Guggenheim Memorial Foundation, 1971
  • Fellow of Alfred P. Sloan Foundation, 1968
  • Member of the Norwegian Academy of Science and Letters, Geoscience

Best Publications

  • Structure, Recognition, and Processing of Cisplatin-DNA Adducts.

    Elizabeth R. Jamieson;Stephen J. Lippard

  • Cellular processing of platinum anticancer drugs.

    Dong Wang;Stephen J. Lippard

  • Tools and tactics for the optical detection of mercuric ion.

    Elizabeth M Nolan;Stephen J Lippard

  • Principles of bioinorganic chemistry

    Stephen J. Lippard;Jeremy M. Berg

  • The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

    Timothy C. Johnstone;Kogularamanan Suntharalingam;Stephen J. Lippard

  • Direct cellular responses to platinum-induced DNA damage

    Yongwon Jung;Stephen J Lippard

  • Structural aspects of platinum anticancer drug interactions with DNA

    Suzanne E. Sherman;Stephen J. Lippard

  • New metal complexes as potential therapeutics.

    Christiana Xin Zhang;Stephen J Lippard

  • Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane

    Amy C. Rosenzweig;Christin A. Frederick;Stephen J. Lippard;Pär Nordlund

  • Reactions of Non-Heme Iron(II) Centers with Dioxygen in Biology and Chemistry

    Andrew L. Feig;Stephen J. Lippard

  • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles

    Shanta Dhar;Frank X. Gu;Robert Langer;Omid C. Farokhzad;Omid C. Farokhzad

  • Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

    Patricia M. Takahara;Amy C. Rosenzweig;Christin A. Frederick;Stephen J. Lippard

  • A "turn-on" fluorescent sensor for the selective detection of mercuric ion in aqueous media.

    Elizabeth M Nolan;Stephen J Lippard

  • Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry.

    Elizabeth M. Nolan;Stephen J. Lippard

  • Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design

    Rodney P. Feazell;Nozomi Nakayama-Ratchford;Hongjie Dai;Stephen J. Lippard

  • Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins

    Maarten Merkx;Daniel A. Kopp;Matthew H. Sazinsky;Jessica L. Blazyk

  • Fluorescent Sensors for Zn2+ Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution

    Shawn C. Burdette;Grant K. Walkup;Bernhard Spingler;Roger Y. Tsien

  • Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.

    Shanta Dhar;Zhuang Liu;Jürgen Thomale;Hongjie Dai

  • Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.

    Uta-Maria Ohndorf;Mark A. Rould;Mark A. Rould;Qing He;Carl O. Pabo

  • Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics.

    Edit Y. Tshuva;Stephen J. Lippard

  • Cisplatin: from DNA damage to cancer chemotherapy.

    Seth M. Cohen;Stephen J. Lippard

Frequent Co-Authors

Amy C. Rosenzweig
Amy C. Rosenzweig Northwestern University
Omid C. Farokhzad
Omid C. Farokhzad Harvard Medical School
Richard A. Friesner
Richard A. Friesner Columbia University
William H. Armstrong
William H. Armstrong Appalachian State University
Simon G. Bott
Simon G. Bott University of Houston
Bernhard Spingler
Bernhard Spingler University of Zurich
Ian D. Williams
Ian D. Williams Hong Kong University of Science and Technology
Michael D. Pluth
Michael D. Pluth University of Oregon

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