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John M. Essigmann

John M. Essigmann

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
22246
World Ranking
4761
National Ranking
2305

Overview

John M. Essigmann is affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their research spans key areas within biochemistry, genetics, molecular biology, and materials science, focusing on the interface between chemical processes and biological systems.

The primary fields of study include Biochemistry, Genetics and Molecular Biology, and Materials Science. Within these disciplines, subfields addressed in their work comprise Materials Chemistry, Molecular Biology, Cancer Research, Health, Toxicology and Mutagenesis, and Spectroscopy.

The main research topics covered by Essigmann's publications are:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Epigenetics and DNA Methylation
  • Carcinogens and Genotoxicity Assessment
  • DNA Repair Mechanisms
  • Water Treatment and Disinfection
  • Cancer Genomics and Diagnostics

Essigmann has contributed to research published in various scientific venues, with frequent publications in:

  • The Cambridge Structural Database
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Research in Toxicology
  • Journal of the American Chemical Society
  • SSRN Electronic Journal

Recent papers authored or co-authored by Essigmann include:

  • "Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice," 2021, Cell Reports
  • "Establishing Linkages Among DNA Damage, Mutagenesis, and Genetic Diseases," 2022, Chemical Research in Toxicology
  • "Metallocalix[4]arene Polymers for Gravimetric Detection of N-Nitrosodialkylamines," 2021, Journal of the American Chemical Society
  • "Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents," 2023, NAR Cancer
  • "7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli," 2022, Nucleic Acids Research

Co-authors frequently collaborating with Essigmann include Robert G. Croy, Timothy M. Swager, Haosheng Feng, Shao-Xiong Lennon Luo, and Bogdan I. Fedeles.

Best Publications

  • Mechanisms of resistance to cisplatin.

    Maria Kartalou;John M Essigmann

  • Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

    Michael L. Wood;Miral Dizdaroglu;Ewa Gajewski;John M. Essigmann

  • Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

    J M Essigmann;R G Croy;A M Nadzan;W F Busby

  • Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions.

    David Wang;Deborah A. Kreutzer;John M. Essigmann

  • In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome

    Edward L. Loechler;Calvert L. Green;John M. Essigmann

  • Mechanisms of Formation, Genotoxicity, and Mutation of Guanine Oxidation Products

    William L. Neeley;John M. Essigmann

  • The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis

    Maryann E. Smela;Sophie S. Currier;Elisabeth A. Bailey;John M. Essigmann

  • Recognition of cisplatin adducts by cellular proteins.

    Maria Kartalou;John M Essigmann

  • Lethal mutagenesis of HIV with mutagenic nucleoside analogs.

    Lawrence A. Loeb;John M. Essigmann;Farhad Kazazi;Jue Zhang

  • Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver

    R G Croy;J M Essigmann;V N Reinhold;G N Wogan

  • The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

    Bogdan I. Fedeles;Vipender Singh;James C. Delaney;Deyu Li

  • Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes

    Jingqing Zhang;Markita P. Landry;Paul W. Barone;Jong Ho Kim;Jong Ho Kim

  • Oxidized, deaminated cytosines are a source of C → T transitions in vivo

    Deborah A. Kreutzer;John M. Essigmann

  • Repair of an Interstrand DNA Cross-link Initiated by ERCC1-XPF Repair/Recombination Nuclease

    Isao Kuraoka;William R. Kobertz;Rafael R. Ariza;Maureen Biggerstaff

  • Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation.

    Nidhi Shrivastav;Deyu Li;John M. Essigmann

  • Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.

    Suzanne L. Bruhn;Pieter M. Pil;John M. Essigmann;David E. Housman

  • Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli.

    James C. Delaney;John M. Essigmann

  • Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents.

    Ashis K. Basu;John M. Essigmann

  • Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

    Ashis K. Basu;Edward L. Loechler;Steven A. Leadon;John M. Essigmann

  • The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin.

    Jill A. Mello;Samir Acharya;Richard Fishel;John M. Essigmann

Frequent Co-Authors

John D. Groopman
John D. Groopman Johns Hopkins University
Kevin J. Yarema
Kevin J. Yarema Johns Hopkins University
Lawrence A. Loeb
Lawrence A. Loeb University of Washington
Martin G. Marinus
Martin G. Marinus University of Massachusetts Chan Medical School
Andrei Tokmakoff
Andrei Tokmakoff University of Chicago

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