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D-Index & Metrics

Molecular Biology

D-Index
119
Citations
56632
World Ranking
267
National Ranking
157

Research.com Recognitions

  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Lawrence A. Loeb is affiliated with the University of Washington in the United States and has contributed to research primarily across the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans various subfields, including Cancer Research, Molecular Biology, Hematology, Genetics, and Pathology and Forensic Medicine.

The scientist has focused extensively on topics related to Cancer Genomics and Diagnostics, Acute Myeloid Leukemia Research, as well as Genetic factors in colorectal cancer and Colorectal Cancer Treatments and Studies. Their research also covers Genomics and Rare Diseases, Histone Deacetylase Inhibitors Research, and Molecular Biology Techniques and Applications.

Lawrence A. Loeb's recent publications include:

  • Rare Mutations in Cancer Drug Resistance and Implications for Therapy, 2020, Clinical Pharmacology & Therapeutics
  • The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53, 2021, UNC Libraries
  • Accurate detection of subclonal variants in paired diagnosis-relapse acute myeloid leukemia samples by next generation Duplex Sequencing, 2022, Leukemia Research
  • Co-Occurring Mutation Clusters Predict Drug Sensitivity in Acute Myeloid Leukemia, 2020, Blood
  • PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage, 2021, Proceedings of the National Academy of Sciences

Frequent collaborators in their research include Brendan F. Kohrn, Robert A. Beckman, Jack D. Griffith, Ashwini S. Kamath-Loeb, and Elihu H. Estey.

Lawrence A. Loeb's work has been published regularly in venues such as UNC Libraries, Clinical Pharmacology & Therapeutics, Leukemia Research, Blood, and the Proceedings of the National Academy of Sciences.

Recognitions awarded to Lawrence A. Loeb include being named a Fellow of the American Academy of Arts and Sciences in 2016 and a Fellow of the American Association for the Advancement of Science (AAAS) in 1986.

Best Publications

  • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.

    Keith C. Cheng;David S. Cahill;Hiroshi Kasai;Susumu Nishimura

  • Mutator Phenotype May Be Required for Multistage Carcinogenesis

    Lawrence A. Loeb

  • Fidelity of HIV-1 reverse transcriptase

    Bradley D. Preston;Bernard J. Poiesz;Lawrence A. Loeb

  • Mutagenesis by Apurinic/Apyrimidinic Sites

    Lawrence A. Loeb;Bradley D. Preston

  • Protein tolerance to random amino acid change

    Haiwei H. Guo;Juno Choe;Lawrence A. Loeb

  • Detection of ultra-rare mutations by next-generation sequencing

    Michael W. Schmitt;Scott R. Kennedy;Jesse J. Salk;Edward J. Fox

  • Multiple mutations and cancer.

    Lawrence A. Loeb;Keith R. Loeb;Jon P. Anderson

  • A Mutator Phenotype in Cancer

    Lawrence A. Loeb

  • Environmental and chemical carcinogenesis.

    Gerald N. Wogan;Stephen S. Hecht;James S. Felton;Allan H. Conney

  • The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

    Aimee L Jackson;Lawrence A Loeb

  • Reactive Oxygen Species in Tumorigenesis

    Daniel I. Feig;Thomas M. Reid;Lawrence A. Loeb

  • Microsatellite Instability: Marker of a Mutator Phenotype in Cancer

    Lawrence A. Loeb

  • The Werner syndrome protein is a DNA helicase.

    Matthew D. Gray;Jiang Cheng Shen;Ashwini S. Kamath-Loeb;A. Blank

  • Fidelity of DNA Synthesis

    Lawrence A. Loeb;Thomas A. Kunkel

  • Errors in DNA Replication as a Basis of Malignant Changes

    Lawrence A. Loeb;Clark F. Springgate;Narayana Battula

  • Significance of multiple mutations in cancer.

    Keith R. Loeb;Lawrence A. Loeb

  • Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.

    Jesse J. Salk;Michael W. Schmitt;Michael W. Schmitt;Lawrence A. Loeb

  • Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens.

    Michael A. Sirover;Lawrence A. Loeb

  • Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

    Dao Fu Dai;Luis Fernando Santana;Marc Vermulst;Daniela M. Tomazela

  • Human Cancers Express Mutator Phenotypes: Origin, Consequences and Targeting

    Lawrence A. Loeb

Frequent Co-Authors

Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health
Michael Fry
Michael Fry Technion – Israel Institute of Technology
George M. Martin
George M. Martin University of Washington
Raymond J. Monnat
Raymond J. Monnat University of Washington
Marshall S. Horwitz
Marshall S. Horwitz University of Washington
Elihu H. Estey
Elihu H. Estey University of Washington
James I. Mullins
James I. Mullins University of Washington
Jerald P. Radich
Jerald P. Radich Fred Hutchinson Cancer Research Center
Peter S. Rabinovitch
Peter S. Rabinovitch University of Washington

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