Robert M. Brosh focuses on Helicase, DNA, Werner Syndrome Helicase, Molecular biology and Genetics. His Helicase research is multidisciplinary, incorporating perspectives in Genome instability, DNA repair and DNA replication. His DNA repair research is multidisciplinary, relying on both DNA damage and Proliferating cell nuclear antigen.
The DNA study combines topics in areas such as Gene and Bloom syndrome. The various areas that he examines in his Werner Syndrome Helicase study include Holliday junction, RecQ helicase and Cell biology. Robert M. Brosh has included themes like Promoter, Transcription factor II F, RNA polymerase II, Transcription factor II D and RNA polymerase II holoenzyme in his Molecular biology study.
Robert M. Brosh mostly deals with Helicase, DNA repair, DNA, Genetics and Genome instability. His work carried out in the field of Helicase brings together such families of science as Molecular biology, DNA replication and Cell biology. His Molecular biology study combines topics in areas such as Cockayne syndrome, Werner Syndrome Helicase and Recombinant DNA.
Robert M. Brosh interconnects Mutation, DNA damage and Homologous recombination in the investigation of issues within DNA repair. His DNA research includes elements of RNA Helicase A, Replication protein A and Computational biology. His Genome instability research includes themes of Flap structure-specific endonuclease 1 and Bloom syndrome.
The scientist’s investigation covers issues in DNA, Helicase, Cell biology, DNA repair and DNA replication. His studies deal with areas such as Computational biology, Transcription, Nucleic acid and Genome as well as DNA. Robert M. Brosh connects Helicase with Chromosome instability in his study.
His Cell biology research is multidisciplinary, incorporating elements of Homologous recombination, Cancer cell, Genome instability, Molecular biology and G-quadruplex. His DNA repair study incorporates themes from Nucleic acid metabolism, DNA damage and Werner syndrome. His work deals with themes such as Werner Syndrome Helicase and DNA synthesis, which intersect with DNA replication.
Robert M. Brosh mainly focuses on DNA replication, DNA repair, DNA, Helicase and Cell biology. His DNA replication study is associated with Genetics. His study in the field of Werner Syndrome Helicase, G-quadruplex and RNA Helicase A also crosses realms of Guanine.
His biological study spans a wide range of topics, including HMG-box and DNA damage, Genome instability. The study incorporates disciplines such as Epigenetics, Gene and Fanconi anemia in addition to DNA damage. His work carried out in the field of DNA brings together such families of science as Replication protein A, Nucleic acid and Molecular biology.
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The Bloom’s and Werner’s syndrome proteins are DNA structure-specific helicases
Payam Mohaghegh;Julia K. Karow;Robert M. Brosh;Vilhelm A. Bohr.
Nucleic Acids Research (2001)
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
Angelos Constantinou;Madalena Tarsounas;Julia K Karow;Robert M Brosh.
EMBO Reports (2000)
Functional and physical interaction between WRN helicase and human replication protein A.
Robert M. Brosh;David K. Orren;Jan O. Nehlin;Peter H. Ravn.
Journal of Biological Chemistry (1999)
Ku complex interacts with and stimulates the Werner protein
Marcus P. Cooper;Amrita Machwe;David K. Orren;Robert M. Brosh.
Genes & Development (2000)
Detection of G-quadruplex DNA in mammalian cells
Alexander Henderson;Yuliang Wu;Yu Chuan Huang;Elizabeth A. Chavez.
Nucleic Acids Research (2014)
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Yuliang Wu;Kazuo Shin-ya;Robert M. Brosh.
Molecular and Cellular Biology (2008)
Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity
Robert M. Brosh;Ji-Liang Li;Mark K. Kenny;Julia K. Karow;Julia K. Karow.
Journal of Biological Chemistry (2000)
DNA helicases involved in DNA repair and their roles in cancer
Robert M. Brosh.
Nature Reviews Cancer (2013)
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Robert M. Brosh;Cayetano von Kobbe;Joshua A. Sommers;Parimal Karmakar.
The EMBO Journal (2001)
G-quadruplexes and helicases.
Oscar Mendoza;Anne Bourdoncle;Anne Bourdoncle;Jean-Baptiste Boulé;Jean-Baptiste Boulé;Robert M. Brosh.
Nucleic Acids Research (2016)
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