World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
70
Citations
15325
World Ranking
2286
National Ranking
1024

Overview

Robert M. Brosh is affiliated with the National Institutes of Health in the United States. Their research predominantly falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a specialized focus on Molecular Biology, Cancer Research, Plant Science, Genetics, and Physiology.

The scientist's work covers multiple topics, including:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Genomics and Chromatin Dynamics
  • Advanced biosensing and bioanalysis techniques

Frequent collaborators in their research include Joshua A. Sommers, Arindam Datta, Tomasz Kulikowicz, Vilhelm A. Bohr, and Steven W. Matson.

Robert M. Brosh has published extensively, contributing major papers such as:

  • "Repeat expansions confer WRN dependence in microsatellite-unstable cancers," 2020, Nature
  • "History of DNA Helicases," 2020, Genes
  • "Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro," 2020, Human Molecular Genetics
  • "WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells," 2021, Nature Communications
  • "DNA helicases and their roles in cancer," 2020, DNA repair

Their frequent publication venues include UNC Libraries, Journal of Biological Chemistry, Cytogenetic and Genome Research, Nature Communications, and Genes.

Best Publications

  • The Bloom’s and Werner’s syndrome proteins are DNA structure-specific helicases

    Payam Mohaghegh;Julia K. Karow;Robert M. Brosh;Vilhelm A. Bohr

  • Detection of G-quadruplex DNA in mammalian cells

    Alexander Henderson;Yuliang Wu;Yu Chuan Huang;Elizabeth A. Chavez

  • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.

    Angelos Constantinou;Madalena Tarsounas;Julia K Karow;Robert M Brosh

  • FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.

    Yuliang Wu;Kazuo Shin-ya;Robert M. Brosh

  • G-quadruplexes and helicases.

    Oscar Mendoza;Anne Bourdoncle;Anne Bourdoncle;Jean-Baptiste Boulé;Jean-Baptiste Boulé;Robert M. Brosh

  • Functional and physical interaction between WRN helicase and human replication protein A.

    Robert M. Brosh;David K. Orren;Jan O. Nehlin;Peter H. Ravn

  • Ku complex interacts with and stimulates the Werner protein

    Marcus P. Cooper;Amrita Machwe;David K. Orren;Robert M. Brosh

  • DNA helicases involved in DNA repair and their roles in cancer

    Robert M. Brosh

  • Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.

    Robert M. Brosh;Ji-Liang Li;Mark K. Kenny;Julia K. Karow;Julia K. Karow

  • Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.

    Robert M. Brosh;Cayetano von Kobbe;Joshua A. Sommers;Parimal Karmakar

  • G‐quadruplex nucleic acids and human disease

    Yuliang Wu;Robert M. Brosh

  • Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.

    Sudha Sharma;Kevin M. Doherty;Robert M. Brosh

  • Human premature aging, DNA repair and RecQ helicases

    Robert M. Brosh;Vilhelm A. Bohr

  • Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

    Monika Aggarwal;Joshua A. Sommers;Robert H. Shoemaker;Robert M. Brosh

  • The FANCJ/MutLα interaction is required for correction of the cross-link response in FA-J cells

    Min Peng;Rachel Litman;Jenny X. Xie;Sudha Sharma

  • Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation

    Parimal Karmakar;Jason Piotrowski;Robert M. Brosh;Joshua A. Sommers

  • The Werner syndrome protein is involved in RNA polymerase II transcription.

    Adayabalam S. Balajee;Amrita Machwe;Alfred May;Matthew D. Gray

  • Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.

    Kevin M. Doherty;Joshua A. Sommers;Matthew D. Gray;Jae Wan Lee

  • Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase.

    Robert M. Brosh;Juwaria Waheed;Joshua A. Sommers

  • Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1

    Sudha Sharma;Joshua A. Sommers;Saba Choudhary;Jinnifer Korin Faulkner

Frequent Co-Authors

Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Ian D. Hickson
Ian D. Hickson University of Copenhagen
Michael M. Seidman
Michael M. Seidman National Institutes of Health
Patricia L. Opresko
Patricia L. Opresko University of Pittsburgh
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
Kazuo Shin-ya
Kazuo Shin-ya National Institute of Advanced Industrial Science and Technology
Tinna Stevnsner
Tinna Stevnsner Aarhus University
Alexander V. Mazin
Alexander V. Mazin Drexel University
Caroline Kisker
Caroline Kisker University of Würzburg

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Genetics, there are several related online degree options and career pathways that complement your studies. Many roles in the healthcare industry benefit from a background in genetics, and pursuing these pathways can broaden your career opportunities.

If you’re looking for a fast entry into the healthcare field, consider medical coding courses. These programs can prepare you for certification and allow you to work in hospitals, clinics, or insurance companies.

Nursing is another popular option. Some students choose easiest nursing programs to get into to quickly start their clinical careers while continuing their studies in genetics or related fields.

If you’re interested in leadership or administrative roles, a healthcare administration degree online accredited can help advance your career. These programs are designed for flexibility, allowing you to balance work and study.

For those seeking a strong foundation in healthcare management, a bachelors in health administration is a valuable credential. With a genetics background, graduates can bring unique insights into healthcare policy and technology fields.

Best Scientists Citing Robert M. Brosh

Trending Scientists