2026 Patricia L. Opresko: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	48	2680	2428	1305	1171	126	9525

Overview

Patricia L. Opresko is affiliated with the University of Pittsburgh in the United States. Their research primarily falls within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus in the subfields of Molecular Biology, Physiology, Oncology, Aging, and Biotechnology.

The scientist's work spans several main topics, including:

Telomeres, Telomerase, and Senescence
DNA Repair Mechanisms
Advanced biosensing and bioanalysis techniques
DNA and Nucleic Acid Chemistry
RNA Interference and Gene Delivery
PARP inhibition in cancer therapy
CRISPR and Genetic Engineering

Patricia L. Opresko has published extensively in various scientific journals. Frequent publication venues include:

bioRxiv (Cold Spring Harbor Laboratory)
Environmental and Molecular Mutagenesis
Nature Communications
Nucleic Acids Research
Biophysical Journal

Among the recent papers authored or co-authored by Opresko are:

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary (2022, Aging)
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening (2022, Nature Structural & Molecular Biology)
Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins (2022, Nature Communications)
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs (2020, Nature Communications)
Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress (2021, Frontiers in Cell and Developmental Biology)

Their collaborations include frequent co-authors such as Ryan Barnes, Samantha L. Sanford, Ariana C. Detwiler, Mariarosaria De Rosa, and Marcel P. Bruchez. These collaborations have contributed to multiple papers across the highlighted research topics.

Best Publications

Human RecQ helicases in DNA repair, recombination, and replication.

Deborah L. Croteau;Venkateswarlu Popuri;Patricia L. Opresko;Vilhelm A. Bohr

629
Citations
Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases

Patricia L. Opresko;Cayetano von Kobbe;Jean-Philippe Laine;Jean-Philippe Laine;Jeanine Harrigan

541
Citations
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Patricia L Opresko;Marit Otterlei;Jesper Graakjær;Per Bruheim

409
Citations
Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study

Aoife O'Donovan;Aoife O'Donovan;Matthew S. Pantell;Eli Puterman;Firdaus S. Dhabhar

376
Citations
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

Patricia L. Opresko;Jinshui Fan;Shamika Danzy;David M. Wilson

350
Citations
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.

Robert M. Brosh;Cayetano von Kobbe;Joshua A. Sommers;Parimal Karmakar

313
Citations
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

Patricia L. Opresko;Wen-Hsing Cheng;Cayetano von Kobbe;Jeanine A. Harrigan

250
Citations
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.

Patricia L. Opresko;Penelope A. Mason;Elaine R. Podell;Ming Lei

235
Citations
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

Elise Fouquerel;Ryan P. Barnes;Shikhar Uttam;Simon C. Watkins

210
Citations
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.

Cayetano von Kobbe;Jeanine A. Harrigan;Alfred May;Patricia L. Opresko

198
Citations
Oxidative guanine base damage regulates human telomerase activity

Elise Fouquerel;Justin Lormand;Arindam Bose;Hui-Ting Lee

178
Citations
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase β

Jeanine A. Harrigan;David M. Wilson;Rajendra Prasad;Patricia L. Opresko

177
Citations
The Werner Syndrome Protein Stimulates DNA Polymerase β Strand Displacement Synthesis via Its Helicase Activity

Jeanine A. Harrigan;Patricia L. Opresko;Cayetano von Kobbe;Padmini S. Kedar

166
Citations
Telomere-associated aging disorders

Patricia L. Opresko;Jerry W. Shay

163
Citations
Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1

Wen-Hsing Cheng;Cayetano von Kobbe;Patricia L. Opresko;L. Matthew Arthur

162
Citations
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.

Cayetano von Kobbe;Parimal Karmakar;Lale Dawut;Patricia Opresko

161
Citations
POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics

Helen Hwang;Noah Buncher;Patricia L. Opresko;Sua Myong

156
Citations
Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.

Nancy Adler;Matthew S. Pantell;Aoife O’Donovan;Aoife O’Donovan;Elizabeth Blackburn

147
Citations
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.

Patricia L. Opresko;Jean-Philippe Laine;Jean-Philippe Laine;Robert M. Brosh;Michael M. Seidman

146
Citations
Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

Laura Garcia-Exposito;Elodie Bournique;Valérie Bergoglio;Arindam Bose

145
Citations

Frequent Co-Authors

Vilhelm A. Bohr University of Copenhagen

Sua Myong Johns Hopkins University

Robert M. Brosh National Institutes of Health

Simon C. Watkins University of Pittsburgh

Bruce A. Armitage Carnegie Mellon University

Anne B. Newman University of Pittsburgh

Richard M. Cawthon University of Utah

Aoife O'Donovan University of California, San Francisco

Tamara B. Harris National Institutes of Health

Susan Smith New York University

External Links

Personal website of Patricia L. Opresko

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