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Biology and Biochemistry

D-Index
55
Citations
11869
World Ranking
14971
National Ranking
273

Overview

Olivier Staub is affiliated with the University of Lausanne in Switzerland. Their research spans several disciplines, primarily focusing on biochemistry, genetics, and molecular biology, with significant work in medicine. The main areas of study include molecular biology, endocrinology, diabetes and metabolism, pulmonary and respiratory medicine, physiology, and nephrology.

The scientist's research topics cover:

  • Ion transport and channel regulation
  • Hormonal regulation and hypertension
  • Electrolyte and hormonal disorders
  • Ion channel regulation and function
  • Renal function and acid-base balance
  • Circadian rhythm and melatonin
  • Birth, development, and health

Olivier Staub has contributed to several scientific publications, with a focus on kidney function, ion channels, and hormonal effects on electrolyte balance. Their recent papers include:

  • "Function and Regulation of the Epithelial Na+ChannelENaC," 2021, Comprehensive physiology
  • "Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis," 2020, Journal of Clinical Investigation
  • "Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone," 2022, Hypertension
  • "Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule," 2020, Journal of the American Society of Nephrology
  • "SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation," 2021, EMBO Reports

Staub has published frequently in several journals, indicating areas of recurring focus:

  • The FASEB Journal (5 publications)
  • American Journal of Physiology-Renal Physiology (3 publications)
  • Comprehensive physiology (2 publications)
  • Journal of Clinical Investigation (1 publication)
  • Hypertension (1 publication)

Collaborations play a role in their work, with several frequent co-authors contributing to multiple publications. These co-authors include Miguel X. van Bemmelen, Wen-Hui Wang, Xin-Peng Duan, Anne Debonneville, and Matteo Stifanelli, with collaboration counts ranging from three to six joint works.

Best Publications

  • WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

    O. Staub;S. Dho;P. C. Henry;J. Correa

  • Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

    O. Staub;I. Gautschi;T. Ishikawa;K. Breitschopf

  • Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression

    Christophe Debonneville;Christophe Debonneville;Sandra Y. Flores;Sandra Y. Flores;Elena Kamynina;Pamela J. Plant

  • Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases.

    D. Rotin;O. Staub;R. Haguenauer-Tsapis

  • Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

    Hugues Abriel;Johannes Loffing;John F. Rebhun;J. Howard Pratt

  • A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

    Elena Kamynina;Christophe Debonneville;Marcelle Bens;Alain Vandewalle

  • Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.

    Stan F.J. van de Graaf;Joost G.J. Hoenderop;Dimitra Gkika;Dennis Lamers

  • Role of ubiquitylation in cellular membrane transport.

    Olivier Staub;Daniela Rotin

  • Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

    Olivier Staub;Hugues Abriel;Pamela Plant;Toru Ishikawa

  • Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

    Miguel X. van Bemmelen;Jean-Sébastien Rougier;Bruno Gavillet;Florine Apothéloz

  • The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization.

    Pamela J. Plant;Herman Yeger;Olivier Staub;Perry Howard

  • Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.

    Elena Kamynina;Olivier Staub

  • Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

    Vivek Bhalla;Dorothée Daidié;Hongyan Li;Alan C. Pao

  • Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.

    Vincent Blot;Fabien Perugi;Marie-Christine Prévost

  • SGK KINASES AND THEIR ROLE IN EPITHELIAL TRANSPORT

    Johannes Loffing;Sandra Y. Flores;Olivier Staub

  • Nedd4-2 Modulates Renal Na+-Cl− Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

    Juan Pablo Arroyo;Dagmara Lagnaz;Caroline Ronzaud;Norma Vázquez

  • Salt-sensitive Hypertension and Cardiac Hypertrophy in Mice Deficient in the Ubiquitin Ligase Nedd4-2

    Peijun P. Shi;Xiao R. Cao;Eileen M. Sweezer;Thomas S. Kinney

  • Early Aldosterone-Induced Gene Product Regulates the Epithelial Sodium Channel by Deubiquitylation

    Panagiotis Fakitsas;Gabriele Adam;Dorothée Daidié;Miguel X. van Bemmelen

  • The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

    Thomas Jespersen;Mathieu Membrez;Céline S. Nicolas;Bruno Pitard

  • Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na+ channel regulation

    Elena Kamynina;Caroline Tauxe;Olivier Staub

Frequent Co-Authors

Daniela Rotin
Daniela Rotin University of Toronto
Gerardo Gamba
Gerardo Gamba National Autonomous University of Mexico
François Verrey
François Verrey University of Zurich
John B. Stokes
John B. Stokes University of Iowa
Jean-Daniel Horisberger
Jean-Daniel Horisberger University of Lausanne
Jean-Pierre Kraehenbuhl
Jean-Pierre Kraehenbuhl University of Lausanne
Wen-Hui Wang
Wen-Hui Wang New York Medical College
Käthi Geering
Käthi Geering University of Lausanne
Sharad Kumar
Sharad Kumar University of Adelaide
Malcolm K. Jones
Malcolm K. Jones University of Queensland

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