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Neuroscience

D-Index
50
Citations
8309
World Ranking
5782
National Ranking
2547

Overview

Michael Mante is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields, primarily focusing on Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Within these areas, they concentrate on the subfields of Neurology, Molecular Biology, Physiology, Pharmacology, and Cell Biology.

The main topics in Michael Mante's work include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's Disease Research and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • HIV Research and Treatment
  • Neurological Disorders and Treatments
  • Cellular Transport and Secretion
  • Ginger and Zingiberaceae Research

The scientist has published in several frequent venues, notable among these are:

  • Neurobiology of Disease
  • Experimental Neurology
  • Journal of NeuroVirology
  • The Journal of Experimental Medicine
  • Experimental & Molecular Medicine

Some of the recent publications associated with Michael Mante include:

  • "Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention" (2021) in The Journal of Experimental Medicine
  • "Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells" (2021) in Experimental & Molecular Medicine
  • "Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models" (2020) in Frontiers in Neuroscience
  • "Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy" (2023) in Neurobiology of Disease
  • "CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy" (2022) in Journal of Neuroscience

Frequent collaborators in Michael Mante's research include:

  • Jazmin Florio
  • Robert A. Rissman
  • Eliezer Masliah
  • Edward Rockenstein
  • Anthony Adame

Best Publications

  • beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.

    Makoto Hashimoto;Edward Rockenstein;Michael Mante;Margaret Mallory

  • Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

    Eliezer Masliah;Edward Rockenstein;Michael Mante;Leslie Crews

  • Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation

    Edward Rockenstein;Magdalena Torrance;Anthony Adame;Michael Mante

  • Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.

    Dora Games;Elvira Valera;Brian Spencer;Edward Rockenstein

  • Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

    Edward Rockenstein;Margaret Mallory;Michael Mante;Abyanné Sisk

  • Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy

    Clifford W. Shults;Edward Rockenstein;Leslie Crews;Anthony Adame

  • Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

    Edward Rockenstein;Silke Nuber;Cassia R. Overk;Kiren Ubhi

  • Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

    Eliezer Masliah;William Samuel;Isaac Veinbergs;Margaret Mallory

  • Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.

    Jennifer Ngolab;Ivy Trinh;Edward Rockenstein;Michael Mante

  • Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

    Markus Mandler;Elvira Valera;Edward Rockenstein;Michael Mante

  • Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

    Kiren Ubhi;Edward Rockenstein;Michael Mante;Chandra Inglis

  • TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

    Andreas Bender;Andreas Bender;Paula Desplats;Brian Spencer;Edward Rockenstein

  • Mutant α-synuclein exacerbates age-related decrease of neurogenesis

    Beate Winner;Edward Rockenstein;D. Chichung Lie;Robert Aigner

  • Cerebrolysin decreases amyloid-β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease

    Edward Rockenstein;Magdalena Torrance;Michael Mante;Anthony Adame

  • Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

    Andrew O. Koob;Kiren Ubhi;Johan F. Paulsson;Jeffery Kelly

  • LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.

    Eun Jin Bae;Dong Kyu Kim;Changyoun Kim;Changyoun Kim;Michael Mante

  • Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.

    Changyoun Kim;Changyoun Kim;Changyoun Kim;Brian Spencer;Edward Rockenstein;Hodaka Yamakado

  • High β-Secretase Activity Elicits Neurodegeneration in Transgenic Mice Despite Reductions in Amyloid-β Levels IMPLICATIONS FOR THE TREATMENT OF ALZHEIMER DISEASE

    Edward Rockenstein;Michael Mante;Michael Alford;Anthony Adame

  • Role of α-Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus

    Beate Winner;Beate Winner;Martin Regensburger;Sebastian Schreglmann;Sebastian Schreglmann;Leah Boyer

  • Effects of Cerebrolysin™ on neurogenesis in an APP transgenic model of Alzheimer’s disease

    Edward Rockenstein;Michael Mante;Anthony Adame;Leslie Crews

  • Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model

    Zacharias Kohl;Beate Winner;Kiren Ubhi;Edward Rockenstein

Frequent Co-Authors

Eliezer Masliah
Eliezer Masliah National Institutes of Health
Edward Rockenstein
Edward Rockenstein University of California, San Diego
Margaret Mallory
Margaret Mallory University of California, San Diego
Beate Winner
Beate Winner University of Erlangen-Nuremberg
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Jürgen Winkler
Jürgen Winkler University of Erlangen-Nuremberg
Charles J. Heyser
Charles J. Heyser University of California, San Diego
William C. Mobley
William C. Mobley University of California, San Diego
Inge Grundke-Iqbal
Inge Grundke-Iqbal University of York
Peter St George-Hyslop
Peter St George-Hyslop Columbia University

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