World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
31442
World Ranking
6130
National Ranking
52

Overview

Seung-Jae Lee is affiliated with Seoul National University in South Korea and has contributed extensively to research in medicine and neuroscience, particularly within the fields of neurology, cellular and molecular neuroscience, and physiology. Their research prominently addresses mechanisms and treatments related to Parkinson's disease, as well as neuroinflammation and neurodegeneration.

Lee's main fields of study include:

  • Medicine
  • Neuroscience

Their subfields of specialization comprise:

  • Neurology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Ophthalmology

The central topics around which Lee's research revolves include:

  • Parkinson's Disease Mechanisms and Treatments
  • Nuclear Receptors and Signaling
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Neurological disorders and treatments
  • Botulinum Toxin and Related Neurological Disorders
  • Lysosomal Storage Disorders Research

Notable recent publications reflect a focus on Parkinson's disease and related neurological studies. These include:

  • Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations (2021), published in Science Advances
  • Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses (2023), published in Science Advances
  • Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations (2021), published in Annals of Neurology
  • LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies (2020), published in Science Translational Medicine
  • TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis (2022), published in Experimental & Molecular Medicine

Frequent co-authors in Lee's research include:

  • Changyoun Kim
  • Byung Chul Jung
  • Eun-Jin Bae
  • Eliezer Masliah
  • Robert A. Rissman

Lee's work has been published in a variety of scientific venues, with several recurrent publications in the following journals:

  • Experimental & Molecular Medicine
  • Science Advances
  • Science Translational Medicine
  • Molecular Brain
  • Acta Neuropathologica Communications

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

    Paula Desplats;He Jin Lee;Eun Jin Bae;Christina Patrick

  • Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

    He Jin Lee;Smita Patel;Seung Jae Lee

  • Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease†

    Michael J. Volles;Seung-Jae Lee;Jean-Christophe Rochet;Mark D. Shtilerman

  • Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

    He Jin Lee;Ji Eun Suk;Christina Patrick;Eun Jin Bae

  • Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

    Changyoun Kim;Dong Hwan Ho;Ji Eun Suk;Sungyong You

  • A detergent-insoluble membrane compartment contains Aβ in vivo

    Seung Jae Lee;Udaya Liyanage;Perry E. Bickel;Perry E. Bickel;Weiming Xia

  • Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

    He-Jin Lee;Chan Choi;Seung-Jae Lee

  • Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

    He Jin Lee;Ji Eun Suk;Eun Jin Bae;Jung Ho Lee

  • Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway

    He-Jin Lee;Farnaz Khoshaghideh;Smita S Patel;Seung-Jae Lee

  • Annular α-Synuclein Protofibrils Are Produced When Spherical Protofibrils Are Incubated in Solution or Bound to Brain-Derived Membranes†

    Tomas T. Ding;Seung Jae Lee;Jean Christophe Rochet;Peter T. Lansbury

  • Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion

    Nirmal Gosavi;He Jin Lee;Jun Sung Lee;Smita Patel

  • Antibody-Aided Clearance of Extracellular α-Synuclein Prevents Cell-to-Cell Aggregate Transmission

    Eun Jin Bae;He Jin Lee;Edward Rockenstein;Dong Hwan Ho

  • Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

    Young Ho Kim;Cheol Yong Choi;Seung-Jae Lee;Mary Anne Conti

  • Non‐classical exocytosis of α‐synuclein is sensitive to folding states and promoted under stress conditions

    Ara Jang;He Jin Lee;Ji Eun Suk;Jin Woo Jung

  • Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors

    He Jin Lee;Soon Young Shin;Chan Choi;Young Han Lee

  • Clearance and deposition of extracellular α-synuclein aggregates in microglia

    He Jin Lee;Ji Eun Suk;Eun Jin Bae;Seung-Jae Lee

  • Cell-to-cell transmission of non-prion protein aggregates.

    Seung-Jae Lee;Paula Desplats;Christina Sigurdson;Igor Tsigelny

  • Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

    He Jin Lee;Eun Jin Bae;Seung Jae Lee

  • Accelerated Oligomerization by Parkinson's Disease Linked α-Synuclein Mutants

    K. A. Conway;S.‐J Lee;J.‐C Rochet;T. T. Ding

Frequent Co-Authors

Pyo-Jam Park
Pyo-Jam Park Konkuk University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
You-Jin Jeon
You-Jin Jeon Jeju National University
Jae-Young Je
Jae-Young Je Pukyong National University
Edward Rockenstein
Edward Rockenstein University of California, San Diego
Phil Hyu Lee
Phil Hyu Lee Yonsei University
Robert A. Rissman
Robert A. Rissman University of California, San Diego
Dong-Kug Choi
Dong-Kug Choi Konkuk University
Michael Mante
Michael Mante University of California, San Diego
Smita S. Patel
Smita S. Patel Rutgers, The State University of New Jersey

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