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Molecular Biology

D-Index
67
Citations
16483
World Ranking
1569
National Ranking
790

Overview

Smita S. Patel is affiliated with Rutgers, The State University of New Jersey in the United States. Their work spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on Molecular Biology within these domains.

Their research primarily addresses topics including:

  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • Advanced biosensing and bioanalysis techniques
  • Mitochondrial Function and Pathology

Recent papers authored by Patel cover a range of molecular biology and biochemistry subjects. Notable publications include:

  • Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device (2022, Science)
  • Structure, mechanism, and regulation of mitochondrial DNA transcription initiation (2020, Journal of Biological Chemistry)
  • Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy (2020, PLoS Pathogens)
  • The dynamic landscape of transcription initiation in yeast mitochondria (2020, Nature Communications)
  • Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles (2020, The EMBO Journal)

Patel frequently collaborates with several coauthors, including:

  • Jiayu Shen
  • Anupam Singh
  • Kalyan Das
  • Urmimala Basu
  • Brent De Wijngaert

Their publications appear in various scientific venues with multiple papers in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature Communications
  • Nucleic Acids Research
  • Molecular Cell

Best Publications

  • Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

    He Jin Lee;Smita Patel;Seung Jae Lee

  • Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant.

    Smita S. Patel;Isaac Wong;Kenneth A. Johnson

  • Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

    Stanley B. Prusiner;Amanda L. Woerman;Daniel A. Mordes;Joel C. Watts

  • Structure and function of hexameric helicases.

    S S Patel;K M Picha

  • Structural basis of RNA recognition and activation by innate immune receptor RIG-I

    Fuguo Jiang;Anand Ramanathan;Matthew T. Miller;Guo Qing Tang

  • An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics.

    Isaac Wong;Smita S. Patel;Kenneth A. Johnson

  • Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway

    He-Jin Lee;Farnaz Khoshaghideh;Smita S Patel;Seung-Jae Lee

  • Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains

    Robert J. Sims;Chi-Fu Chen;Helena Santos-Rosa;Tony Kouzarides

  • Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion

    Nirmal Gosavi;He Jin Lee;Jun Sung Lee;Smita Patel

  • Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases.

    Edward H. Egelman;Xiong Yu;Robert Wild;Manju M. Hingorani

  • Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

    Swapnil C. Devarkar;Chen Wang;Matthew T. Miller;Anand Ramanathan

  • Mechanisms of Helicases

    Smita S. Patel;Ilker Donmez

  • Single-Molecule Studies Reveal Dynamics of DNA Unwinding by the Ring-Shaped T7 Helicase

    Daniel S. Johnson;Lu Bai;Benjamin Y. Smith;Smita S. Patel

  • Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction.

    Maureen J. Donlin;Smita S. Patel;Kenneth A. Johnson

  • Propagation of prions causing synucleinopathies in cultured cells

    Amanda L. Woerman;Jan Stöhr;Atsushi Aoyagi;Ryan Rampersaud

  • Histone chaperone FACT action during transcription through chromatin by RNA polymerase II

    Fu-Kai Hsieh;Olga I. Kulaeva;Olga I. Kulaeva;Smita S. Patel;Pamela N. Dyer

  • DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase

    Natalie M. Stano;Yong Joo Jeong;Yong Joo Jeong;Ilker Donmez;Padmaja Tummalapalli

  • Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss

    J J Kril;S Patel;A J Harding;G M Halliday

  • A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.

    Mikhail K Levin;Madhura Gurjar;Smita S Patel

  • Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

    Amanda L. Woerman;Atsushi Aoyagi;Atsushi Aoyagi;Smita Patel;Sabeen A. Kazmi

Frequent Co-Authors

Taekjip Ha
Taekjip Ha Johns Hopkins University
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Dong-Eun Kim
Dong-Eun Kim Konkuk University
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Kenneth A. Johnson
Kenneth A. Johnson The University of Texas at Austin
Edward H. Egelman
Edward H. Egelman University of Virginia
Seung-Jae Lee
Seung-Jae Lee Seoul National University
Xiong Yu
Xiong Yu University of Virginia
Ann M. Stock
Ann M. Stock Rutgers, The State University of New Jersey
Megerditch Kiledjian
Megerditch Kiledjian Rutgers, The State University of New Jersey

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