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Biology and Biochemistry

D-Index
87
Citations
27124
World Ranking
2831
National Ranking
1454

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1974 - Fellow of American Physical Society (APS)
  • 1971 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Kenneth A. Johnson is affiliated with The University of Texas at Austin in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine.

Their main subfields of study include Molecular Biology, Infectious Diseases, Genetics, Ecology, and Materials Chemistry. The scientist's work focuses on key topics such as:

  • RNA and protein synthesis mechanisms
  • DNA and Nucleic Acid Chemistry
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Bacterial Genetics and Biotechnology
  • Advanced biosensing and bioanalysis techniques
  • SARS-CoV-2 and COVID-19 Research

Recent publications by Kenneth A. Johnson highlight research in structural biology, enzyme mechanisms, and viral replication:

  • Structural basis for mismatch surveillance by CRISPR-Cas9, 2022, Nature
  • Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication, 2021, Molecular Cell
  • Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA, 2020, Nature Communications
  • Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase, 2020, iScience
  • Visible Light Mediated Bidirectional Control over Carbonic Anhydrase Activity in Cells and in Vivo Using Azobenzenesulfonamides, 2020, Journal of the American Chemical Society

Kenneth A. Johnson has frequently published in several scientific journals, including:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Nature

Collaborations are an important part of their career, with frequent coauthors including Tyler L. Dangerfield, David W. Taylor, Jack P. K. Bravo, Nathan Huang, and Serdal Kırmızıaltın.

Throughout their career, Kenneth A. Johnson has received multiple fellowships, such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2006
  • Fellow of American Physical Society (APS), 1974
  • Fellow of John Simon Guggenheim Memorial Foundation, 1971

Best Publications

  • The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper

    Kenneth A. Johnson;Roger S. Goody

  • Conformational Coupling in DNA Polymerase Fidelity

    Kenneth A. Johnson

  • Mechanism and fidelity of HIV reverse transcriptase.

    W. M. Kati;Kenneth Johnson;L. F. Jerva;K. S. Anderson

  • Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant.

    Smita S. Patel;Isaac Wong;Kenneth A. Johnson

  • Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors

    Rebecca A. Spence;Warren M. Kati;Karen S. Anderson;Kenneth A. Johnson

  • Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

    Carol A. Fierke;Kenneth A. Johnson;Stephen J. Benkovic

  • Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

    Kenneth A. Johnson;Zachary B. Simpson;Thomas Blom

  • An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics.

    Isaac Wong;Smita S. Patel;Kenneth A. Johnson

  • PURIFICATION OF TUBULIN AND ASSOCIATED HIGH MOLECULAR WEIGHT PROTEINS FROM PORCINE BRAIN AND CHARACTERIZATION OF MICROTUBULE ASSEMBLY IN VITRO

    G. G. Borisy;J. M. Marcum;J. B. Olmsted;D. B. Murphy

  • Kinetic Mechanism of DNA Polymerase I (Klenow)

    R. D. Kuchta;V. Mizrahi;P. A. Benkovic;K. A. Johnson

  • 1 Transient-State Kinetic Analysis of Enzyme Reaction Pathways

    Kenneth A. Johnson

  • Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

    Allison A. Johnson;Adrian S. Ray;Jeremiah W. Hanes;Zucai Suo

  • FitSpace explorer: an algorithm to evaluate multidimensional parameter space in fitting kinetic data.

    Kenneth A. Johnson;Zachary B. Simpson;Thomas Blom

  • Pathway of processive ATP hydrolysis by kinesin

    Susan P. Gilbert;Martin R. Webb;Martin Brune;Kenneth A. Johnson

  • Kinetic analysis of microtubule self-assembly in vitro

    Kenneth A. Johnson;Gary G. Borisy

  • Structure of the DNA repair helicase XPD.

    Huanting Liu;Jana Rudolf;Kenneth A. Johnson;Stephen A. McMahon

  • A New Paradigm for DNA Polymerase Specificity

    Yu-Chih Tsai;Kenneth A. Johnson

  • The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense.

    A. Di Matteo;L. Federici;B. Mattei;G. Salvi

  • Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

    Kenneth A. Johnson

  • Role of tubulin-associated proteins in microtubule nucleation and elongation.

    Douglas B. Murphy;Kenneth A. Johnson;Gary G. Borisy

Frequent Co-Authors

Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Smita S. Patel
Smita S. Patel Rutgers, The State University of New Jersey
Karen S. Anderson
Karen S. Anderson Yale University
Ron Elber
Ron Elber The University of Texas at Austin
Daniel Z. Freedman
Daniel Z. Freedman Stanford University
Gary G. Borisy
Gary G. Borisy ADA Forsyth Institute
Valerie Mizrahi
Valerie Mizrahi University of Cape Town
Carol A. Fierke
Carol A. Fierke Texas A&M University
Klaus Klumpp
Klaus Klumpp Janssen (Belgium)
Edward M. Marcotte
Edward M. Marcotte The University of Texas at Austin

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