Klaus Klumpp

Overview

Best Publications

• The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture *

  Klaus Klumpp;Vincent Lévêque;Sophie Le Pogam;Han Ma

  332
  Citations

• A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients

  Nguyet Minh Nguyen;Chau Nguyen Bich Tran;Lam Khanh Phung;Kien Thi Hue Duong

  314
  Citations

• Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure.

  Klaus Klumpp;Rob W.H. Ruigrok;Florence Baudin

  292
  Citations

• Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.

  Klaus Klumpp;Julie Qi Hang;Surendran Rajendran;Yanli Yang

  210
  Citations

• In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.

  Sophie Le Pogam;Wen-Rong Jiang;Vincent Leveque;Sonal Rajyaguru

  177
  Citations

• Structure of the Unphosphorylated STAT5a Dimer

  Dante Neculai;Ana Mirela Neculai;Sophie Verrier;Kenneth Straub

  174
  Citations

• High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

  Klaus Klumpp;Angela M. Lam;Christine Lukacs;Robert Vogel

  161
  Citations

• Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species

  Han Ma;Wen-Rong Jiang;Nicole Robledo;Vincent Leveque

  158
  Citations

• Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

  Sophie Le Pogam;Hyunsoon Kang;Seth F. Harris;Vincent Leveque

  155
  Citations

• Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

  Samir Ali;Vincent Leveque;Sophie Le Pogam;Han Ma

  154
  Citations

• Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection

  Man Fung Yuen;Edward J. Gane;Dong Joon Kim;Frank Weilert

  149
  Citations

• Robust antiviral activity of R1626, a novel nucleoside analog: A randomized, placebo‐controlled study in patients with chronic hepatitis C

  Stuart K. Roberts;Graham Cooksley;Gregory J. Dore;Richard Robson

  144
  Citations

• Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

  David B. Smith;Joseph A. Martin;Joseph A. Martin;Klaus Klumpp;Stewart J. Baker

  141
  Citations

• In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

  Xiao Tong;Sophie Le Pogam;Lewyn Li;Kristin Haines

  131
  Citations

• The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.

  David B. Smith;Genadiy Kalayanov;Christian Sund;Anna Winqvist

  130
  Citations

• H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load

  Adrianus C. M. Boon;David Finkelstein;Ming Zheng;Guochun Liao

  119
  Citations

• Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

  Julie Qi Hang;Yanli Yang;Seth F. Harris;Vincent Leveque

  118
  Citations

• 2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups

  Klaus Klumpp;Genadiy Kalayanov;Han Ma;Sophie Le Pogam

  113
  Citations

• The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.

  Choongho Lee;Han Ma;Julie Qi Hang;Vincent Leveque

  111
  Citations

• The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).

  Christopher McGuigan;Mary Rose Kelleher;Plinio Perrone;Sinead Mulready

  109
  Citations