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Klaus Klumpp

Klaus Klumpp

Janssen (Belgium)
Belgium

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
6998
World Ranking
17777
National Ranking
295

Klaus Klumpp publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Klaus Klumpp sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 134 publications — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Klaus Klumpp D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Klaus Klumpp sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 50 D-Index — 11th percentile

11% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Klaus Klumpp is affiliated with Janssen in Belgium and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields, including infectious diseases, molecular biology, epidemiology, oncology, and hepatology.

The scientist's work encompasses several key topics, notably SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, ubiquitin and proteasome pathways, hepatitis B virus studies, hepatitis C virus research, Pneumocystis jirovecii pneumonia detection and treatment, and animal virus infections studies.

Klumpp has published numerous papers, with recent notable publications including:

  • Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19 (2022, Nature)
  • Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19 (2021, bioRxiv - Cold Spring Harbor Laboratory)
  • First-in-human experience using RBS2418, an oral ENPP1 inhibitor within an expanded access protocol in combination with pembrolizumab in a patient with metastatic adrenal cancer (2022, Journal of Clinical Oncology)
  • Identification of a new class of HBV capsid assembly modulator (2021, Bioorganic & Medicinal Chemistry Letters)
  • Oxadiazepinone HBV capsid assembly modulators (2021, Bioorganic & Medicinal Chemistry Letters)

The scientist frequently publishes in journals such as the Journal of Clinical Oncology, bioRxiv (Cold Spring Harbor Laboratory), Bioorganic & Medicinal Chemistry Letters, Nature, and PLoS Pathogens.

Klumpp collaborates often with several co-authors, including:

  • Kevin Wilhelmsen
  • Jian Zheng
  • Fred Aswad
  • Justin Rebo
  • David K. Meyerholz

The collective research efforts explore therapeutic avenues and molecular mechanisms particularly relevant to infectious diseases and oncology. Their publications show a focus on viral infections and immune response modulation, aligning closely with investigations into COVID-19 and hepatitis viruses.

Best Publications

  • The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture *

    Klaus Klumpp;Vincent Lévêque;Sophie Le Pogam;Han Ma

  • A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients

    Nguyet Minh Nguyen;Chau Nguyen Bich Tran;Lam Khanh Phung;Kien Thi Hue Duong

  • Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure.

    Klaus Klumpp;Rob W.H. Ruigrok;Florence Baudin

  • Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.

    Klaus Klumpp;Julie Qi Hang;Surendran Rajendran;Yanli Yang

  • In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.

    Sophie Le Pogam;Wen-Rong Jiang;Vincent Leveque;Sonal Rajyaguru

  • Structure of the Unphosphorylated STAT5a Dimer

    Dante Neculai;Ana Mirela Neculai;Sophie Verrier;Kenneth Straub

  • High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

    Klaus Klumpp;Angela M. Lam;Christine Lukacs;Robert Vogel

  • Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species

    Han Ma;Wen-Rong Jiang;Nicole Robledo;Vincent Leveque

  • Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

    Sophie Le Pogam;Hyunsoon Kang;Seth F. Harris;Vincent Leveque

  • Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

    Samir Ali;Vincent Leveque;Sophie Le Pogam;Han Ma

  • Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection

    Man Fung Yuen;Edward J. Gane;Dong Joon Kim;Frank Weilert

  • Robust antiviral activity of R1626, a novel nucleoside analog: A randomized, placebo‐controlled study in patients with chronic hepatitis C

    Stuart K. Roberts;Graham Cooksley;Gregory J. Dore;Richard Robson

  • Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

    David B. Smith;Joseph A. Martin;Joseph A. Martin;Klaus Klumpp;Stewart J. Baker

  • In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

    Xiao Tong;Sophie Le Pogam;Lewyn Li;Kristin Haines

  • The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.

    David B. Smith;Genadiy Kalayanov;Christian Sund;Anna Winqvist

  • H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load

    Adrianus C. M. Boon;David Finkelstein;Ming Zheng;Guochun Liao

  • Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

    Julie Qi Hang;Yanli Yang;Seth F. Harris;Vincent Leveque

  • 2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups

    Klaus Klumpp;Genadiy Kalayanov;Han Ma;Sophie Le Pogam

  • The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.

    Choongho Lee;Han Ma;Julie Qi Hang;Vincent Leveque

  • The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).

    Christopher McGuigan;Mary Rose Kelleher;Plinio Perrone;Sinead Mulready

Frequent Co-Authors

Mark D. Smith
Mark D. Smith University of South Carolina
George D. Hartman
George D. Hartman Janssen (Belgium)
Maura Dandri
Maura Dandri Universität Hamburg
Marc Lütgehetmann
Marc Lütgehetmann University Medical Center Hamburg-Eppendorf
Jeffrey S. Glenn
Jeffrey S. Glenn Stanford University
Fabien Zoulim
Fabien Zoulim Inserm
Kenneth A. Johnson
Kenneth A. Johnson The University of Texas at Austin
Antonio Bertoletti
Antonio Bertoletti Duke NUS Graduate Medical School
David Durantel
David Durantel Inserm
Staffan Eriksson
Staffan Eriksson Swedish University of Agricultural Sciences

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Best Scientists Citing Klaus Klumpp

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Fabien Zoulim

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Antonio Bertoletti

Antonio Bertoletti

Duke NUS Graduate Medical School

Publications: 36

Christophe Pannecouque

Christophe Pannecouque

Rega Institute for Medical Research

Publications: 30

Pei-Yong Shi

Pei-Yong Shi

GlaxoSmithKline (United Kingdom)

Publications: 26

Johan Neyts

Johan Neyts

Rega Institute for Medical Research

Publications: 25

Maura Dandri

Maura Dandri

Universität Hamburg

Publications: 25

Bruno Canard

Bruno Canard

Aix-Marseille University

Publications: 22

David Durantel

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Inserm

Publications: 21

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Stefan Zeuzem

Goethe University Frankfurt

Publications: 21

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Ralf Bartenschlager

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Publications: 19

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Hongmei Mo

Gilead Sciences (United States)

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