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Chemistry

D-Index
51
Citations
9881
World Ranking
13894
National Ranking
2155

Overview

Peng Zhan is affiliated with Shandong University in China, contributing extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans several key subfields, including infectious diseases, molecular biology, virology, epidemiology, and organic chemistry.

The primary research topics addressed by Peng Zhan include:

  • HIV/AIDS drug development and treatment
  • HIV research and treatment
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Computational drug discovery methods
  • Click chemistry and applications
  • Hepatitis C virus research
  • SARS-CoV-2 and COVID-19 research

Peng Zhan has published numerous papers in well-known scientific venues. Frequent publication venues encompass:

  • Journal of Medicinal Chemistry (35 publications)
  • European Journal of Medicinal Chemistry (23 publications)
  • Chinese Chemical Letters (11 publications)
  • Drug Discovery Today (6 publications)
  • Bioorganic & Medicinal Chemistry (6 publications)

Among recent papers authored or co-authored by Peng Zhan are:

  • "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling," 2020, Signal Transduction and Targeted Therapy
  • "Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities," 2020, Journal of Medicinal Chemistry
  • "Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses," 2021, Chemical Society Reviews
  • "SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules," 2022, Signal Transduction and Targeted Therapy
  • "Recent developments in the medicinal chemistry of single boron atom-containing compounds," 2021, Acta Pharmaceutica Sinica B

Peng Zhan frequently collaborates with several co-authors in their field, including:

  • Xinyong Liu
  • Dongwei Kang
  • Christophe Pannecouque
  • Erik De Clercq
  • Shujing Xu

In addition to journal publications, Peng Zhan has contributed to book publications. Notably, a title published by Springer Nature is "Antiviral Drug Discovery and Development" (2021), which has received citations.

Best Publications

  • Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

    Peng Zhan;Christophe Pannecouque;Erik De Clercq;Xinyong Liu

  • Conformational restriction: an effective tactic in 'follow-on'-based drug discovery

    Zengjun Fang;Yu'ning Song;Peng Zhan;Qingzhu Zhang

  • 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

    Yu'ning Song;Hao Xu;Wenmin Chen;Peng Zhan

  • Recent applications of click chemistry in drug discovery.

    Xiangyi Jiang;Xia Hao;Lanlan Jing;Gaochan Wu

  • Current drug research on PEGylation with small molecular agents

    Wenjun Li;Peng Zhan;Erik De Clercq;Hongxiang Lou

  • Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

    Siyu Xiu;Alexej Dick;Han Ju;Sako Mirzaie

  • Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries.

    Xueshun Wang;Boshi Huang;Xinyong Liu;Peng Zhan

  • The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

    Vigneshwaran Namasivayam;Murugesan Vanangamudi;Victor G. Kramer;Sonali Kurup

  • Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

    Dongwei Kang;Zengjun Fang;Zhenyu Li;Boshi Huang

  • Overview of Recent Strategic Advances in Medicinal Chemistry

    Gaochan Wu;Tong Zhao;Dongwei Kang;Jian Zhang

  • Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

    Dongyue Li;Peng Zhan;Erik De Clercq;Xinyong Liu

  • Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

    Yue Ma;Estrella Frutos-Beltrán;Dongwei Kang;Christophe Pannecouque

  • 1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents

    Z. Li;P. Zhan;X. Liu

  • Recent advances in DAPYs and related analogues as HIV-1 NNRTIs.

    Xuwang Chen;Peng Zhan;Dongyue Li;Erik De Clercq

  • Design Strategies of Novel NNRTIs to Overcome Drug Resistance

    Peng Zhan;Xinyong Liu;Zhenyu Li;Christophe Pannecouque

  • Recent developments in the medicinal chemistry of single boron atom-containing compounds

    Shu Song;Ping Gao;Lin Sun;Dongwei Kang

  • Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

    Dongwei Kang;Zengjun Fang;Boshi Huang;Xueyi Lu

  • Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches

    Boshi Huang;Cuicui Li;Wenmin Chen;Tao Liu

  • Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies

    Peng Zhan;Xinyong Liu;Zhenyu Li;Zengjun Fang

  • Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.

    Takayoshi Suzuki;Hiroki Ozasa;Yukihiro Itoh;Peng Zhan

  • Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

    Ye Tian;Zhaoqiang Liu;Jinghan Liu;Boshi Huang

  • Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

    Ye Tian;Deping Du;Diwakar Rai;Liu Wang

  • Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

    Takayoshi Suzuki;Takayoshi Suzuki;Yuki Kasuya;Yukihiro Itoh;Yosuke Ota

  • Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

    Boshi Huang;Wenmin Chen;Tong Zhao;Zhenyu Li

  • 1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

    Peng Zhan;Xinyong Liu;Yuan Cao;Yan Wang

Frequent Co-Authors

Xinyong Liu
Xinyong Liu Shandong University
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Jan Balzarini
Jan Balzarini KU Leuven
Luis Menéndez-Arias
Luis Menéndez-Arias Spanish National Research Council
Takayoshi Suzuki
Takayoshi Suzuki Osaka University
Chin Ho Chen
Chin Ho Chen Duke University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Hong Liu
Hong Liu Shandong University
Jacob Kongsted
Jacob Kongsted University of Southern Denmark

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