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Immunology

D-Index
64
Citations
21137
World Ranking
2896
National Ranking
27

Overview

Zhiwei Chen is affiliated with the University of Hong Kong in China and has contributed extensively to the field of medicine, with a focus on infectious diseases, molecular biology, immunology, epidemiology, and oncology. Their research spans multiple interrelated domains, including SARS-CoV-2 and COVID-19 research, COVID-19 clinical studies, immune cell function and interaction, immunotherapy and immune responses, viral detection methods, epigenetics, and RNA modifications related to cancer.

The scientist has coauthored numerous publications alongside several frequent collaborators, notably Kwok-Yung Yuen, Runhong Zhou, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, and Li Liu. Their articles have appeared in a variety of scientific venues, with frequent contributions to the SSRN Electronic Journal, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, EBioMedicine, and Research Square (Research Square).

Key recent papers include:

  • Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study (2020, The Lancet Infectious Diseases)
  • Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike (2020, Nature)
  • Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility (2020, Clinical Infectious Diseases)
  • Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5 (2022, Nature)
  • Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses (2020, Immunity)

Zhiwei Chen's body of work is primarily situated within medicine, with 373 publications contributing to this field. Among these, 120 publications relate specifically to infectious diseases, highlighting the scientist's focus on viral pathogens and their clinical and immunological impact.

The scientist's frequent publication venues provide a view of their active engagement with open research platforms and peer-reviewed journals that focus on the biomedical sciences and translational medicine. The variety of venues and topics reflects a multidisciplinary approach tailored to understanding COVID-19 pathogenesis, immune responses, and potential therapeutic interventions.

Frequent co-authors:

  • Kwok-Yung Yuen
  • Runhong Zhou
  • Kelvin Kai-Wang To
  • Jasper Fuk-Woo Chan
  • Li Liu

Frequent publication venues:

  • SSRN Electronic Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • EBioMedicine
  • Research Square (Research Square)

Main fields of study:

  • Medicine

Subfields of study:

  • Infectious Diseases
  • Molecular Biology
  • Immunology
  • Epidemiology
  • Oncology

Main research topics:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • SARS-CoV-2 detection and testing
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer

Best Publications

  • Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.

    Kelvin Kai Wang To;Owen Tak Yin Tsang;Wai Shing Leung;Anthony Raymond Tam

  • Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.

    Lihong Liu;Pengfei Wang;Manoj S. Nair;Jian Yu

  • Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility.

    Jasper Fuk Woo Chan;Jasper Fuk Woo Chan;Jasper Fuk Woo Chan;Anna Jinxia Zhang;Shuofeng Yuan;Vincent Kwok Man Poon

  • Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

    Li Liu;Qiang Wei;Qingqing Lin;Jun Fang

  • Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

    Runhong Zhou;Kelvin Kai Wang To;Yik Chun Wong;Li Liu

  • Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR

    Stefan Pöhlmann;Jie Zhang;Frédéric Baribaud;Zhiwei Chen

  • Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques

    Li Liu;Qiang Wei;Xavier Alvarez;Haibo Wang

  • Genetically Divergent Strains of Simian Immunodeficiency Virus Use CCR5 as a Coreceptor for Entry

    Z Chen;P Zhou;D D Ho;N R Landau

  • International AIDS Society global scientific strategy: towards an HIV cure 2016

    Steven G Deeks;Sharon R Lewin;Anna Laura Ross;Jintanat Ananworanich

  • SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion

    Unknown

  • Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

    Joris Hemelaar;Ramyiadarsini Elangovan;Jason Yun;Leslie Dickson-Tetteh

  • The changing face of HIV in China

    Lin Lu;Manhong Jia;Yanling Ma;Li Yang

  • Genetic characterization of New West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop.

    Z Chen;P Telfier;A Gettie;P Reed

  • Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.

    Zhiwei Chen;Amara Luckay;Donald L. Sodora;Paul Telfer

  • Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction.

    Siu Ying Lau;Pui Wang;Bobo Wing Yee Mok;Anna Jinxia Zhang

  • Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.

    Zhiwei Chen;Linqi Zhang;Chuan Qin;Lei Ba

  • Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

    Man Lung Yeung;Jade Lee Lee Teng;Lilong Jia;Chaoyu Zhang

  • Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer

    Xu Chen;Jingtong Zhang;Weimei Ruan;Ming Huang

  • Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

    Linqi Zhang;Fengwen Zhang;Wenjie Yu;Tian He

  • Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

    Jingying Zhou;Man Liu;Hanyong Sun;Yu Feng

  • Chemokine Coreceptor Usage by Diverse Primary Isolates of Human Immunodeficiency Virus Type 1

    Linqi Zhang;Tian He;Yaoxing Huang;Zhiwei Chen

  • Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.

    Richard Y. Kao;Wayne H.W. Tsui;Terri S.W. Lee;Julian A. Tanner

  • Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China.

    Yong Zhang;Lin Lu;Lei Ba;Li Liu;Li Liu

Frequent Co-Authors

Kwok-Yung Yuen
Kwok-Yung Yuen University of Hong Kong
David D. Ho
David D. Ho Columbia University
Kelvin K. W. To
Kelvin K. W. To University of Hong Kong
Jasper F. W. Chan
Jasper F. W. Chan University of Hong Kong
Yaoxing Huang
Yaoxing Huang Columbia University
Kwok-Hung Chan
Kwok-Hung Chan University of Hong Kong
Linqi Zhang
Linqi Zhang Tsinghua University
Preston A. Marx
Preston A. Marx Tulane University
Chuan Qin
Chuan Qin Peking Union Medical College Hospital
Hin Chu
Hin Chu University of Hong Kong

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