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Chemistry

D-Index
72
Citations
30132
World Ranking
5145
National Ranking
374

Overview

Nicholas A. Meanwell is affiliated with Bristol-Myers Squibb (Germany) and has contributed extensively to the fields of Medicine and Chemistry, with a strong focus on Organic Chemistry and Materials Chemistry. Their work spans subfields such as Infectious Diseases, Molecular Biology, and Virology.

The main topics that characterize their research include

  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Synthesis and Catalytic Reactions
  • Chemical Synthesis and Analysis
  • Catalytic C-H Functionalization Methods

Meanwell's publication record highlights contributions to notable journals and specialized fields. Frequent publication venues include

  • Journal of Medicinal Chemistry
  • The Cambridge Structural Database
  • Synfacts
  • ACS Medicinal Chemistry Letters
  • The Journal of Organic Chemistry

The scientist has collaborated regularly with several coauthors, including

  • Arvind Mathur
  • Mark Krystal
  • James Kempson
  • T. G. Murali Dhar
  • Susan Jenkins

Selected recent papers authored by Nicholas A. Meanwell include

  • "Applications of Bioisosteres in the Design of Biologically Active Compounds," 2023, Journal of Agricultural and Food Chemistry
  • "Metabolic and Pharmaceutical Aspects of Fluorinated Compounds," 2020, Journal of Medicinal Chemistry
  • "Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design," 2021, Journal of Medicinal Chemistry

In addition to articles, Meanwell has contributed to book publications, including:

  • Antiprotozoal Drug Development and Delivery, published by Springer Nature in 2022

Best Publications

  • Applications of Fluorine in Medicinal Chemistry

    Eric P. Gillis;Kyle J. Eastman;Matthew D. Hill;David J. Donnelly

  • Synopsis of some recent tactical application of bioisosteres in drug design.

    Nicholas A. Meanwell

  • Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

    Nicholas A. Meanwell

  • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

    Min Gao;Richard E. Nettles;Makonen Belema;Lawrence B. Snyder

  • A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

    Brett R. Beno;Kap-Sun Yeung;Michael D. Bartberger;Lewis D. Pennington

  • Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.

    Nicholas A. Meanwell

  • Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

    Benjamin M. Johnson;Yue-Zhong Shu;Xiaoliang Zhuo;Nicholas A. Meanwell

  • Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.

    Murugaiah A. M. Subbaiah;Nicholas A. Meanwell

  • A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding

    Pin-Fang Lin;Wade Blair;Tao Wang;Timothy Spicer

  • Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.

    Valentin K. Gribkoff;John E. Starrett;Steven I. Dworetzky;Piyasena Hewawasam

  • Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.

    Tao Wang;Zhongxing Zhang;Owen B. Wallace;Milind Deshpande

  • Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

    Nicholas A. Meanwell

  • Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.

    Piyasena Hewawasam;Matthew Erway;Sandra L. Moon;Jay Knipe

  • Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.

    Qi Guo;Hsu-Tso Ho;Ira Dicker;Li Fan

  • The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.

    Piyasena Hewawasam;Valentin K. Gribkoff;Yadagiri Pendri;Steven I. Dworetzky

  • Azetidin-2-one derivatives as inhibitors of thrombin.

    William T. Han;Ashok K. Trehan;J.J. Kim Wright;Marianne E. Federici

  • Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.

    V K Gribkoff;J T Lum-Ragan;C G Boissard;D J Post-Munson

  • Applications of fluorine-containing amino acids for drug design.

    Haibo Mei;Jianlin Han;Karel D. Klika;Kunisuke Izawa

  • Identification of Hepatitis C Virus NS5A Inhibitors

    Julie A. Lemm;Donald O'Boyle;Mengping Liu;Peter T. Nower

  • Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

    Tao Wang;Zhongxing Zhang;Nicholas A. Meanwell;John F. Kadow

  • Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

    Fiona McPhee;Amy K. Sheaffer;Jacques Friborg;Dennis Hernandez

Frequent Co-Authors

Mark Krystal
Mark Krystal ViiV Healthcare (United Kingdom)
Lawrence G. Hamann
Lawrence G. Hamann Bristol-Myers Squibb (Germany)
Richard J. Colonno
Richard J. Colonno Bristol-Myers Squibb (Germany)
Susan B. Roberts
Susan B. Roberts Tufts University
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Vadim A. Soloshonok
Vadim A. Soloshonok University of the Basque Country
Guangxiang Luo
Guangxiang Luo University of Alabama at Birmingham
Gunda I. Georg
Gunda I. Georg University of Minnesota

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