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Chemistry

D-Index
41
Citations
10025
World Ranking
17661
National Ranking
1278

Overview

Lawrence G. Hamann is affiliated with Bristol-Myers Squibb in Germany, working primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans a range of subfields, including Molecular Biology, Immunology, Organic Chemistry, Physiology, and Oncology.

Their work focuses on several main scientific topics:

  • Protein Degradation and Inhibitors
  • Multiple Myeloma Research and Treatments
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Vanadium and Halogenation Chemistry
  • Nitric Oxide and Endothelin Effects
  • Prostate Cancer Treatment and Research
  • Radical Photochemical Reactions

Lawrence G. Hamann has contributed to multiple peer-reviewed publications, with notable papers including:

  • Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma, 2020, Journal of Medicinal Chemistry
  • Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins, 2020, Journal of the American Chemical Society
  • Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex, 2020, Nature Structural & Molecular Biology
  • Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes, 2021, Journal of the American Chemical Society
  • Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders, 2020, Journal of Medicinal Chemistry

Their frequent co-authors include Rama Krishna Narla, Joseph R. Piccotti, Brian E. Cathers, Jake Axford, and Joshua D. Hansen, each collaborating on multiple projects.

Lawrence's research has been disseminated primarily through the following venues:

  • Journal of Medicinal Chemistry
  • Journal of the American Chemical Society
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database

Best Publications

  • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

    Min Gao;Richard E. Nettles;Makonen Belema;Lawrence B. Snyder

  • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

    Ranjan Mukherjee;Peter J. A. Davies;Diane L. Crombie;Eric D. Bischoff

  • Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

    David J Augeri;Jeffrey A Robl;David A Betebenner;David R Magnin

  • Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

    William E. Dowdle;Beat Nyfeler;Jane Nagel;Robert A. Elling

  • Development of targeted protein degradation therapeutics

    Philip P Chamberlain;Lawrence G Hamann

  • SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

    James Palacino;Susanne E Swalley;Cheng Song;Atwood K Cheung

  • SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.

    Mary E Matyskiela;Suzana Couto;Xinde Zheng;Gang Lu

  • Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

    Marian C. Bryan;Barry Dillon;Lawrence G. Hamann;Gregory J. Hughes

  • Steroid receptor modulator compounds and methods

    Todd K. Jones;Mark E. Goldman;Charlotte L.F. Pooley;David T. . Winn

  • Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.

    Lawrence G. Hamann;Robert I. Higuchi;Lin Zhi;James P. Edwards

  • Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071)

    Lawrence G. Hamann;Neelakandha S. Mani;Robert L. Davis;Xiao-Ning Wang

  • Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.

    Joshua D. Hansen;Matthew Correa;Mark A. Nagy;Matt Alexander

  • Pyrrolopyridine-based inhibitors of dipeptidyl peptidase iv and methods

    Wei Meng;Lawrence G. Hamann;Robert Paul Brigance

  • Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

    Jacek Ostrowski;Joyce E. Kuhns;John A. Lupisella;Mark C. Manfredi

  • Method and compound for producing dipeptidyl peptidase iv inhibitor and intermediate thereof

    David J Augeri;David B Brzozowski;Rita Fox;Jollie Duaine Godfrey

  • Inhibitors of 11-beta hydroxysteroid dehydrogenase type i

    James J. Li;Lawrence G. Hamann;Zheming Ruan;Christopher B. Cooper

  • Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

    William J. Metzler;Joseph Yanchunas;Carolyn Weigelt;Kevin Kish

  • Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion

    Jing He;Lawrence G. Hamann;Huw M. L. Davies;Rohan E. J. Beckwith

  • Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

    James P. Edwards;Robert I. Higuchi;David T. Winn;Charlotte L.F. Pooley

  • Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

    David R Magnin;Jeffrey A Robl;Richard B Sulsky;David J Augeri

  • Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.

    Julien Genovino;Dalibor Sames;Lawrence G. Hamann;B. Barry Touré

  • Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins.

    Claire G. Page;Simon J. Cooper;Jacob S. Dehovitz;Daniel G. Oblinsky

  • Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

    Atwood K. Cheung;Brian Hurley;Ryan Kerrigan;Lei Shu

  • Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

    George S. Tria;Tinya Abrams;Jason Baird;Heather E. Burks

Frequent Co-Authors

Nicholas A. Meanwell
Nicholas A. Meanwell Bristol-Myers Squibb (Germany)
Ashish Khanna
Ashish Khanna Maharaja Agrasen Institute of Technology (MAIT)
David W. Green
David W. Green University College London
Tao Wang
Tao Wang Stanford University
Richard J. Colonno
Richard J. Colonno Bristol-Myers Squibb (Germany)
William Fenical
William Fenical University of California, San Diego

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