World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
79
Citations
21844
World Ranking
17607
National Ranking
8800

Overview

James T. Dalton is affiliated with St. Jude Children's Research Hospital in the United States. Their research spans several fields, with significant focus in medicine and biochemistry, genetics, and molecular biology. The scientist's work notably covers areas such as prostate cancer treatment and research, hormonal and reproductive studies, estrogen and related hormone effects, as well as evolution and genetic dynamics.

Dalton's publications address a range of topics within biomedical research. Recent work includes the following papers:

  • "Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth," 2021, Journal of Clinical Investigation
  • "Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth," 2021, Journal of Clinical Investigation
  • "Deregulation of DUX4 and ERG in acute lymphoblastic leukemia," 2020, UNC Libraries
  • "An automated system for interrogating the evolution of microbial endosymbiosis," 2022, Lab on a Chip
  • "Modulation of the Androgen Receptor Axis," 2021, Burger's Medicinal Chemistry and Drug Discovery

The scientist has frequently collaborated with colleagues such as Michael D. Nyquist, Lisa S. Ang, Alexandra Corella, Ilsa M. Coleman, and Michael P. Meers. These collaborations reflect joint contributions of multiple publications, particularly in the area of prostate cancer and hormonal studies.

Dalton's research has been published across various venues, indicating a breadth of scholarly engagement. These include:

  • Journal of Clinical Investigation
  • UNC Libraries
  • Lab on a Chip
  • Burger's Medicinal Chemistry and Drug Discovery
  • The Journal of Heart and Lung Transplantation

Their body of work intersects with several subfields, including genetics, pulmonary and respiratory medicine, endocrinology, diabetes and metabolism, and biomedical engineering. This diversity underlines engagement with multidisciplinary approaches in biomedical research.

Main topics in Dalton's research encompass:

  • Prostate cancer treatment and research
  • Hormonal and reproductive studies
  • Estrogen and related hormone effects
  • Evolution and genetic dynamics
  • Innovative microfluidic and catalytic techniques innovation
  • Bacterial genetics and biotechnology
  • Mechanical circulatory support devices

Best Publications

  • BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

    Charles G. Mullighan;Christopher B. Miller;Ina Radtke;Letha A. Phillips

  • Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations

    Margaret C. Thompson;Christine Fuller;Twala L. Hogg;James Dalton

  • Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

    Xiang Chen;Armita Bahrami;Alberto Pappo;John Easton

  • Chemistry and structural biology of androgen receptor

    Wenqing Gao;Casey E. Bohl;James T. Dalton

  • Structural basis for antagonism and resistance of bicalutamide in prostate cancer.

    Casey E. Bohl;Wenqing Gao;Duane D. Miller;Charles E. Bell

  • Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

    Nai-Kong V. Cheung;Jinghui Zhang;Charles Lu;Matthew Parker

  • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia.

    John C. Byrd;Thomas S. Lin;James T. Dalton;Di Wu

  • YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

    Africa Fernandez-L;Paul A. Northcott;James Dalton;Charles Fraga

  • The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

    James T. Dalton;Kester G. Barnette;Casey E. Bohl;Michael L. Hancock

  • Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

    Adrian S Dobs;Ralph V Boccia;Christopher C Croot;Nashat Y Gabrail

  • Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

    Shontelle Dodson;Vickie E. Baracos;Aminah Jatoi;William J. Evans

  • Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging.

    Shalender Bhasin;Olga M Calof;Thomas W Storer;Martin L Lee

  • Discovery of Nonsteroidal Androgens

    James T. Dalton;Arnab Mukherjee;Zixin Zhu;Leonid Kirkovsky

  • Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs).

    Wenqing Gao;James T. Dalton

  • Selective androgen receptor modulators in preclinical and clinical development

    Ramesh K. Narayanan;Michael L. Mohler;Casey E. Bohl;Duane D Miller

  • Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry.

    Zengru Wu;Wenqing Gao;Mitch A. Phelps;Di Wu

  • Structural basis for accommodation of nonsteroidal ligands in the androgen receptor.

    Casey E. Bohl;Duane D. Miller;Jiyun Chen;Charles E. Bell

  • Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

    Michael L. Mohler;Casey E. Bohl;Amanda Jones;Christopher C. Coss

  • Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele

    Robert S. Kidd;Arthur B. Straughn;Marvin C. Meyer;Joyce Blaisdell

  • Pharmacodynamics of Selective Androgen Receptor Modulators

    Donghua Yin;Wenqing Gao;Jeffrey D. Kearbey;Huiping Xu

Frequent Co-Authors

Duane D. Miller
Duane D. Miller University of Tennessee Health Science Center
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Wei Li
Wei Li University of Tennessee Health Science Center
Michael R. Grever
Michael R. Grever The Ohio State University
Ching-Shih Chen
Ching-Shih Chen The Ohio State University
Amar Gajjar
Amar Gajjar St. Jude Children's Research Hospital
Richard J. Gilbertson
Richard J. Gilbertson University of Cambridge
Erin G. Schuetz
Erin G. Schuetz St. Jude Children's Research Hospital
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Ellis R. Levin
Ellis R. Levin University of California, Irvine

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