World's Best Scientists 2026 revealed!

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Immunology

D-Index
134
Citations
83987
World Ranking
197
National Ranking
128

Medicine

D-Index
139
Citations
86549
World Ranking
1736
National Ranking
994

Research.com Recognitions

  • 2017 - Max Delbruck Prize, Division of Biological Physics of the American Physical Society For profound contributions to theoretical immunology, which bring insight and save lives.
  • 2015 - Fellow of American Physical Society (APS) Citation For seminal contributions to the development of dynamical models of HIV infection, for elucidating therapeutic responses of HCV, and for helping found the fields of viral dynamics and theoretical immunology
  • 2009 - SIAM Fellow For contributions to viral dynamics and other problems of mathematical biology.
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Fellow of the American Academy of Arts and Sciences

Overview

Alan S. Perelson is affiliated with Los Alamos National Laboratory in the United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with significant contributions to the study of Infectious Diseases, Epidemiology, Virology, Immunology, and Modeling and Simulation.

The scientist's work covers several main topics, including:

  • SARS-CoV-2 and COVID-19 Research
  • HIV Research and Treatment
  • COVID-19 Clinical Research Studies
  • COVID-19 epidemiological studies
  • Hepatitis C virus research
  • HIV/AIDS Research and Interventions
  • Immune Cell Function and Interaction

Notable recent papers published by Alan S. Perelson include:

  • "Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load," 2020, CPT Pharmacometrics & Systems Pharmacology
  • "In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness," 2021, Proceedings of the National Academy of Sciences
  • "A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2," 2021, PLoS Biology
  • "Mechanistic Modeling of SARS-CoV-2 and Other Infectious Diseases and the Effects of Therapeutics," 2021, Clinical Pharmacology & Therapeutics
  • "The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy," 2023, Journal of Clinical Investigation

The scientist frequently collaborates with the following co-authors:

  • Ruy M. Ribeiro
  • Ruian Ke
  • Jonathan Z. Li
  • Joseph J. Eron
  • Eric S. Daar

Alan S. Perelson has published extensively in several venues, among which the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • PLoS Computational Biology
  • Proceedings of the National Academy of Sciences
  • SSRN Electronic Journal

The scientist has been recognized with a number of awards, including:

  • Max Delbruck Prize, Division of Biological Physics of the American Physical Society, 2017, for contributions to theoretical immunology
  • Fellow of American Physical Society (APS), 2015, for work on dynamical models of HIV infection, therapeutic responses of HCV, and viral dynamics fields
  • SIAM Fellow, 2009, for contributions to viral dynamics and mathematical biology
  • Fellow of the American Association for the Advancement of Science (AAAS), 2006
  • Fellow of the American Academy of Arts and Sciences, 1999

Best Publications

  • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

    David D. Ho;Avidan U. Neumann;Alan S. Perelson;Wen Chen

  • HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

    Alan S. Perelson;Avidan U. Neumann;Martin Markowitz;John M. Leonard

  • Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

    Avidan U. Neumann;Nancy P. Lam;Harel Dahari;David R. Gretch

  • Decay characteristics of HIV-1-infected compartments during combination therapy

    Alan S. Perelson;Paulina Essunger;Yunzhen Cao;Mika Vesanen

  • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

    Brandon F. Keele;Elena E. Giorgi;Elena E. Giorgi;Jesus F. Salazar-Gonzalez;Julie M. Decker

  • The immune system, adaptation, and machine learning

    J D Farmer;N H Packard;A S Perelson

  • Mathematical Analysis of HIV-1 Dynamics in Vivo

    Alan S. Perelson;Patrick W. Nelson

  • Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques

    Xia Jin;Daniel E. Bauer;Sarah E. Tuttleton;Sharon Lewin

  • Dynamics of HIV infection of CD4+ T cells

    Alan S. Perelson;Denise E. Kirschner;Rob De Boer

  • Modelling viral and immune system dynamics

    Alan S. Perelson

  • Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis

    Vladimir A. Kuznetsov;Iliya A. Makalkin;Mark A. Taylor;Alan S. Perelson

  • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy.

    Linqi Zhang;B. Ramratnam;K. Tenner-Racz;Yuxian He

  • Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

    Jesus F. Salazar-Gonzalez;Maria G. Salazar;Brandon F. Keele;Gerald H. Learn

  • Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue

    Ashley T. Haase;Keith Henry;Mary Zupancic;Gerlad Sedgewick

  • Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

    Georgia D. Tomaras;Nicole L. Yates;Pinghuang Liu;Li Qin

  • Kinetics of Influenza A Virus Infection in Humans

    Prasith Baccam;Catherine Beauchemin;Catherine A. Macken;Frederick G. Hayden

  • Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination.

    Alan S. Perelson;Alan S. Perelson;George F. Oster

  • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

    Nilu Goonetilleke;Michael K.P. Liu;Jesus F. Salazar-Gonzalez;Guido Ferrari

  • Immunology for physicists

    Alan S. Perelson;Gérard Weisbuch

  • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy

    Manohar R. Furtado;Duncan S. Callaway;John P. Phair;Kevin J. Kunstman

Frequent Co-Authors

Ruy M. Ribeiro
Ruy M. Ribeiro Los Alamos National Laboratory
David D. Ho
David D. Ho Columbia University
Bette T. Korber
Bette T. Korber Los Alamos National Laboratory
Stephanie Forrest
Stephanie Forrest Arizona State University
Martin Markowitz
Martin Markowitz Rockefeller University
Rob J. de Boer
Rob J. de Boer Utrecht University
George M. Shaw
George M. Shaw University of Pennsylvania
Beatrice H. Hahn
Beatrice H. Hahn University of Pennsylvania
Avidan U. Neumann
Avidan U. Neumann Bar-Ilan University
Brandon F. Keele
Brandon F. Keele National Institutes of Health

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