World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
17245
World Ranking
12332
National Ranking
5279

Overview

Jeffrey G. McDonald is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans multiple disciplines, mainly within Biochemistry, Genetics and Molecular Biology and Medicine. The scientist's work covers 135 publications in Biochemistry, Genetics and Molecular Biology and 130 in Medicine.

The subfields of study that Jeffrey G. McDonald has contributed to include Molecular Biology, Surgery, Cancer Research, Immunology, and Cell Biology. The research topics they focus on include:

  • Cholesterol and Lipid Metabolism
  • Cancer, Lipids, and Metabolism
  • Sphingolipid Metabolism and Signaling
  • Lipid metabolism and biosynthesis
  • Mitochondrial Function and Pathology
  • Liver Disease Diagnosis and Treatment
  • Adipose Tissue and Metabolism

The scientist has published frequently in several venues, demonstrating a broad engagement with high-impact journals. Key publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory), 16 publications
  • Nature Communications, 10 publications
  • Proceedings of the National Academy of Sciences, 7 publications
  • Journal of Investigative Dermatology, 4 publications
  • Nature Metabolism, 3 publications

Some of Jeffrey G. McDonald's recent papers include:

  • "Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis," 2020, Immunity
  • "Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression," 2020, Nature Metabolism
  • "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," 2022, Nature Communications
  • "Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol," 2020, Nature Microbiology
  • "Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine," 2020, Proceedings of the National Academy of Sciences

Throughout their career, Jeffrey G. McDonald has collaborated frequently with a number of co-authors, including:

  • Gonçalo Vale, 43 collaborations
  • Bonne M. Thompson, 18 collaborations
  • Kaitlyn M. Eckert, 15 collaborations
  • Chase D. Corley, 11 collaborations
  • K. Dengke, 6 collaborations

Best Publications

  • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

    Takeshi Inagaki;Mihwa Choi;Antonio Moschetta;Li Peng

  • Lipidomics reveals a remarkable diversity of lipids in human plasma

    Oswald Quehenberger;Aaron M. Armando;Alex H. Brown;Stephen B. Milne

  • Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

    Nathanael J. Spann;Lana X. Garmire;Jeffrey G. McDonald;David S. Myers

  • Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

    Arun Radhakrishnan;Joseph L. Goldstein;Jeffrey G. McDonald;Michael S. Brown

  • 25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon

    Andrea Reboldi;Eric V. Dang;Jeffrey G. McDonald;Guosheng Liang

  • Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

    Chendong Yang;Jessica Sudderth;Tuyen Dang;Robert G. Bachoo

  • 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

    David R. Bauman;Andrew D. Bitmansour;Jeffrey G. McDonald;Bonne M. Thompson

  • Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

    D. Lee Gorden;David S. Myers;Pavlina T. Ivanova;Eoin Fahy

  • Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands

    Chendong Yang;Jeffrey G. McDonald;Amit Patel;Yuan Zhang

  • 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

    Qian Wu;Tomonori Ishikawa;Rosa Sirianni;Hao Tang

  • A Mouse Macrophage Lipidome

    Edward A. Dennis;Raymond A. Deems;Richard Harkewicz;Oswald Quehenberger

  • Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

    Eric V. Dang;Jeffrey G. McDonald;David W. Russell;Jason G. Cyster

  • Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

    Jonathan Y. Xia;William L. Holland;Christine M. Kusminski;Kai Sun

  • Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

    Jason S. Seidman;Ty D. Troutman;Mashito Sakai;Anita Gola

  • Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.

    Mashito Sakai;Ty D. Troutman;Jason S. Seidman;Zhengyu Ouyang

  • Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.

    Brian C. Monk;Thomas M. Tomasiak;Mikhail V. Keniya;Franziska U. Huschmann

  • A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

    Jeffrey G. McDonald;Daniel D. Smith;Ashlee R. Stiles;David W. Russell

  • Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

    Mahesh S. Padanad;Georgia Konstantinidou;Niranjan Venkateswaran;Margherita Melegari

  • A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

    Christie M Buchovecky;Stephen D Turley;Hannah M Brown;Hannah M Brown;Stephanie M Kyle

  • Subcellular organelle lipidomics in TLR-4-activated macrophages,

    Alexander Y. Andreyev;Eoin Fahy;Ziqiang Guan;Samuel Kelly

Frequent Co-Authors

David W. Russell
David W. Russell University of Washington
Christopher K. Glass
Christopher K. Glass University of California, San Diego
Edward A. Dennis
Edward A. Dennis University of California, San Diego
Alfred H. Merrill
Alfred H. Merrill Georgia Institute of Technology
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
H. Alex Brown
H. Alex Brown Vanderbilt University
Ronald A. Hites
Ronald A. Hites Indiana University
Ralph J. DeBerardinis
Ralph J. DeBerardinis The University of Texas Southwestern Medical Center
Oswald Quehenberger
Oswald Quehenberger University of California, San Diego
Robert C. Murphy
Robert C. Murphy University of Colorado Denver

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