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Molecular Biology

D-Index
43
Citations
8706
World Ranking
2963
National Ranking
203

Overview

Inna N. Lavrik is affiliated with Otto-von-Guericke University Magdeburg in Germany. Their research is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on Molecular Biology, Oncology, Epidemiology, Immunology, and Cancer Research.

The main topics addressed in Lavrik's work include:

  • Cell death mechanisms and regulation
  • Autophagy in Disease and Therapy
  • Cancer-related Molecular Pathways
  • RNA modifications and cancer
  • Phagocytosis and Immune Regulation
  • RNA Interference and Gene Delivery
  • Protein Kinase Regulation and GTPase Signaling

Recent papers authored or coauthored by Lavrik feature research published between 2020 and 2021 across various scientific journals. These include:

  • Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks, 2021, Trends in Cancer
  • Controlling Cell Death through Post-translational Modifications of DED Proteins, 2020, Trends in Cell Biology
  • The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications, 2020, Cell Death Discovery
  • Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer, 2020, Cell Death and Differentiation
  • YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulating NF-κB Activation, 2020, Cancers

The scientist frequently collaborates with a number of coauthors. Frequent collaborators include:

  • Nikita V. Ivanisenko
  • В. А. Иванисенко
  • Kamil Seyrek
  • Corinna König
  • Laura K. Hillert-Richter

Lavrik's work has been published multiple times in venues such as:

  • Vavilov Journal of Genetics and Breeding (4 publications)
  • Trends in Cell Biology (3 publications)
  • Frontiers in Cell and Developmental Biology (3 publications)
  • Cancers (2 publications)
  • Journal of Visualized Experiments (2 publications)

Best Publications

  • Caspases: pharmacological manipulation of cell death

    Inna N. Lavrik;Alexander Golks;Peter H. Krammer

  • Life and death in peripheral T cells

    Peter H. Krammer;Rüdiger Arnold;Inna N. Lavrik

  • Death receptor signaling

    Inna Lavrik;Alexander Golks;Peter H. Krammer

  • Regulation of CD95/Fas signaling at the DISC

    I N Lavrik;P H Krammer

  • Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

    M. Bentele;I N Lavrik;M. M. W. Ulrich;S. Stößer

  • c-FLIPR, a new regulator of death receptor-induced apoptosis

    Alexander Golks;Dirk Brenner;Cornelius Fritsch;Peter H. Krammer

  • The c-FLIP–NH2 terminus (p22-FLIP) induces NF-κB activation

    Alexander Golks;Dirk Brenner;Peter H. Krammer;Inna N. Lavrik

  • Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

    Kolja Schleich;Uwe Warnken;Nicolai Fricker;Selcen Öztürk

  • Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.

    Sabine Pietkiewicz;Jörn H. Schmidt;Inna N. Lavrik

  • Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

    Nicolai Fricker;Joel Beaudouin;Petra Richter;Roland Eils;Roland Eils

  • Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

    Leo Neumann;Leo Neumann;Carina Pforr;Joel Beaudouin;Joel Beaudouin;Alexander Pappa

  • Analysis of CD95 Threshold Signaling: TRIGGERING OF CD95 (FAS/APO-1) AT LOW CONCENTRATIONS PRIMARILY RESULTS IN SURVIVAL SIGNALING

    Inna N. Lavrik;Alexander Golks;Dagmar Riess;Martin Bentele

  • Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions.

    Selcen Öztürk;Kolja Schleich;Inna N. Lavrik

  • A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

    Yannick Boege;Mohsen Malehmir;Marc E. Healy;Kira Bettermann

  • The active caspase-8 heterotetramer is formed at the CD95 DISC

    I. Lavrik;A. Krueger;I. Schmitz;S. Baumann

  • The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities

    Jia Y. Zhu;Inna N. Lavrik;Ulrich Mahlknecht;Marco Giaisi

  • Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

    Alexey V. Zamaraev;Gelina S. Kopeina;Evgeniia A. Prokhorova;Boris Zhivotovsky;Boris Zhivotovsky

  • Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

    Yves Matthess;Monika Raab;Mourad Sanhaji;Inna N. Lavrik

  • Systems biology of apoptosis signaling networks

    Inna N Lavrik

  • The E. coli Effector Protein NleF Is a Caspase Inhibitor

    Sonja Blasche;Mario Mörtl;Holger Steuber;Gabriella Siszler

Frequent Co-Authors

Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Peter H. Krammer
Peter H. Krammer German Cancer Research Center
Roland Eils
Roland Eils Charité - University Medicine Berlin
Kai Sundmacher
Kai Sundmacher Max Planck Institute for Dynamics of Complex Technical Systems
Alexei A. Bogdanov
Alexei A. Bogdanov University of Massachusetts Chan Medical School
Michael Naumann
Michael Naumann Otto-von-Guericke University Magdeburg
Evgeny I. Rogaev
Evgeny I. Rogaev University of Massachusetts Chan Medical School
Björn H. Schott
Björn H. Schott University of Göttingen
Dirk Schlüter
Dirk Schlüter Otto-von-Guericke University Magdeburg
Martina Schnölzer
Martina Schnölzer German Cancer Research Center

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