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Biology and Biochemistry

D-Index
81
Citations
21920
World Ranking
3929
National Ranking
94

Overview

Andrew J. Brown is affiliated with the University of New South Wales in Australia. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine. Their scholarly work includes 73 publications in Biochemistry, Genetics and Molecular Biology and 70 in Medicine, reflecting a broad interdisciplinary approach.

Brown's research covers several primary topics, including cholesterol and lipid metabolism, cancer, lipids, and metabolism, lipid metabolism and biosynthesis, plant biochemistry and biosynthesis, ubiquitin and proteasome pathways, steroid chemistry and biochemistry, and peroxisome proliferator-activated receptors.

The scientist has contributed frequently to a number of publication venues. These include arXiv (Cornell University) with 9 papers, Journal of Biological Chemistry with 7 papers, The FASEB Journal with 6 papers, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids with 5 papers, and Journal of Lipid Research with 3 papers.

Brown has collaborated with several frequent co-authors, among them Laura J. Sharpe with 20 joint publications, Hudson W. Coates with 14, Isabelle M. Capell-Hattam with 9, Hongyuan Yang with 8, and Nicole Fenton with 8 as well.

Selected recent papers authored or co-authored by Andrew J. Brown include:

  • Oxysterols: From physiological tuners to pharmacological opportunities, 2020, British Journal of Pharmacology
  • Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis, 2020, Gastroenterology
  • Squalene monooxygenase: a journey to the heart of cholesterol synthesis, 2020, Progress in Lipid Research
  • A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, 2021, Science
  • A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate, 2020, Proceedings of the National Academy of Sciences

Best Publications

  • Oxysterols and atherosclerosis

    Andrew J Brown;Wendy Jessup

  • Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers.

    P Simmonds;P Balfe;J F Peutherer;C A Ludlam

  • The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State

    G. Enrico Rovati;Valérie Capra;Richard R. Neubig

  • ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

    Ingrid C. Gelissen;Matthew Harris;Kerry-Anne Rye;Carmel Quinn

  • Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism

    Andrew J Brown;Liping Sun;Jamison D Feramisco;Michael S Brown

  • Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.

    Weihua Fei;Guanghou Shui;Bruno Gaeta;Ximing Du

  • Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

    Laura J. Sharpe;Laura J. Sharpe;Andrew J. Brown

  • A role for phosphatidic acid in the formation of "supersized" lipid droplets.

    Weihua Fei;Guanghou Shui;Yuxi Zhang;Natalie Krahmer

  • The Akt–SREBP nexus: cell signaling meets lipid metabolism

    James R. Krycer;Laura J. Sharpe;Winnie Luu;Andrew J. Brown

  • Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.

    Andrew J. Brown;Wendy Jessup

  • A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

    Ximing Du;Jaspal Kumar;Charles Ferguson;Timothy A. Schulz

  • Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

    Saloni Gill;Julian Stevenson;Ika Kristiana;Andrew J. Brown

  • 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque.

    A J Brown;S L Leong;R T Dean;W Jessup

  • Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised

    Saloni Gill;Renee Chow;Andrew J Brown

  • Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n−3 polyunsaturated fatty acids: study design implications

    A. J. Brown;E. Pang;D. C. K. Roberts

  • GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

    Nariman A B Balenga;Elma Aflaki;Julia Kargl;Wolfgang Platzer

  • Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages.

    Andrew J. Brown;Roger T. Dean;Wendy Jessup

  • Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.

    Shane R. Thomas;Steven B. Leichtweis;Knut Pettersson;Kevin D. Croft

  • Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis.

    Joanne M. Upston;Xianwa Niu;Andrew J. Brown;Ryuichi Mashima

  • Involvement of Akt in ER-to-Golgi Transport of SCAP/SREBP: A Link between a Key Cell Proliferative Pathway and Membrane Synthesis

    Ximing Du;Ika Kristiana;Jenny Wong;Andrew J. Brown

Frequent Co-Authors

Wendy Jessup
Wendy Jessup Concord Repatriation General Hospital
Roger T. Dean
Roger T. Dean Western Sydney University
Hongyuan Yang
Hongyuan Yang University of New South Wales
Kerry-Anne Rye
Kerry-Anne Rye University of New South Wales
Robert G. Parton
Robert G. Parton University of Queensland
Elina Ikonen
Elina Ikonen University of Helsinki
Brett Garner
Brett Garner University of Wollongong
Roland Stocker
Roland Stocker The Heart Research Institute
Vesa M. Olkkonen
Vesa M. Olkkonen University of Helsinki
Ian W. Dawes
Ian W. Dawes University of New South Wales

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