His primary areas of study are Biochemistry, Cholesterol, Sterol, Oxysterol and Sterol regulatory element-binding protein. His Cholesterol study integrates concerns from other disciplines, such as Liver X receptor and ABCA1. His ABCA1 research includes elements of Efflux, Transcription factor and HMG-CoA reductase.
Andrew J. Brown has included themes like Alpha, Sterol O-acyltransferase and Cytotoxicity in his Oxysterol study. The Sterol regulatory element-binding protein study combines topics in areas such as Transport protein, Cell biology and Lipid metabolism. His 27-Hydroxycholesterol course of study focuses on In vivo and Homeostasis.
Andrew J. Brown focuses on Cholesterol, Biochemistry, Cell biology, Internal medicine and Endocrinology. ABCA1 is closely connected to Liver X receptor in his research, which is encompassed under the umbrella topic of Cholesterol. His biological study spans a wide range of topics, including Ubiquitin and Ubiquitin ligase.
His Endocrinology research is multidisciplinary, incorporating perspectives in LNCaP and Antioxidant, Vitamin E. He usually deals with Oxysterol and limits it to topics linked to Metabolism and In vitro. He interconnects Flux and Homeostasis in the investigation of issues within Sterol.
Andrew J. Brown mostly deals with Cell biology, Squalene monooxygenase, Cholesterol, Enzyme and Biochemistry. The concepts of his Cell biology study are interwoven with issues in Ubiquitin ligase and Sterol. In his study, which falls under the umbrella issue of Sterol, Receptor is strongly linked to Reductase.
His Squalene monooxygenase study combines topics from a wide range of disciplines, such as Ubiquitin, Gene knockdown, Cancer stem cell, Squalene and Metastasis. His Cholesterol research is covered under the topics of Internal medicine and Endocrinology. Andrew J. Brown has researched Enzyme in several fields, including Immune system and Proteasome.
Andrew J. Brown mainly investigates Cholesterol, Cell biology, Squalene monooxygenase, Ubiquitin ligase and Enzyme. His research on Cholesterol concerns the broader Biochemistry. His Lanosterol and HMG-CoA reductase study in the realm of Biochemistry interacts with subjects such as Degradation.
His Cell biology research incorporates themes from Transcriptional regulation and Cell growth. The study incorporates disciplines such as Squalene, Computational biology, Cholesterol biosynthesis and Mechanism of action in addition to Squalene monooxygenase. The various areas that Andrew J. Brown examines in his Enzyme study include Cell metabolism, Cell, Oxysterol, Immune system and Function.
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Oxysterols and atherosclerosis
Andrew J Brown;Wendy Jessup.
ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I
Ingrid C. Gelissen;Matthew Harris;Kerry-Anne Rye;Carmel Quinn.
Arteriosclerosis, Thrombosis, and Vascular Biology (2005)
Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism
Andrew J Brown;Liping Sun;Jamison D Feramisco;Michael S Brown.
Molecular Cell (2002)
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.
Weihua Fei;Guanghou Shui;Bruno Gaeta;Ximing Du.
Journal of Cell Biology (2008)
A role for phosphatidic acid in the formation of "supersized" lipid droplets.
Weihua Fei;Guanghou Shui;Yuxi Zhang;Natalie Krahmer.
PLOS Genetics (2011)
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.
Andrew J. Brown;Wendy Jessup.
Molecular Aspects of Medicine (2009)
7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque.
A J Brown;S L Leong;R T Dean;W Jessup.
Journal of Lipid Research (1997)
Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)
Laura J. Sharpe;Laura J. Sharpe;Andrew J. Brown.
Journal of Biological Chemistry (2013)
A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking
Ximing Du;Jaspal Kumar;Charles Ferguson;Timothy A. Schulz.
Journal of Cell Biology (2011)
The Akt–SREBP nexus: cell signaling meets lipid metabolism
James R. Krycer;Laura J. Sharpe;Winnie Luu;Andrew J. Brown.
Trends in Endocrinology and Metabolism (2010)
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