2023 - Research.com Biology and Biochemistry in United States Leader Award
2022 - Research.com Best Scientist Award
2003 - Albany Medical Center Prize in Medicine and Biomedical Research
1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.
1990 - Fellow of the American Association for the Advancement of Science (AAAS)
1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan at a White House Ceremony on July 15, 1988. Awarded jointly with Dr. Joseph L. Goldstein, University of Texas Southwestern Medical Center.
1987 - Member of the National Academy of Medicine (NAM)
1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism
1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
1985 - William Allan Award, the American Society of Human Genetics
1984 - Louisa Gross Horwitz Prize, Columbia University
1981 - Fellow of the American Academy of Arts and Sciences
1981 - Canada Gairdner International Award
1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.
Member of the Association of American Physicians
Michael S. Brown mainly focuses on Biochemistry, Endocrinology, Internal medicine, Sterol regulatory element-binding protein and Cholesterol. LDL receptor, Sterol, Low-density lipoprotein, HMG-CoA reductase and Binding site are among the areas of Biochemistry where the researcher is concentrating his efforts. He interconnects Receptor, Endocytosis and Familial hypercholesterolemia in the investigation of issues within LDL receptor.
Michael S. Brown mostly deals with Adipose tissue in his studies of Internal medicine. Within one scientific family, Michael S. Brown focuses on topics pertaining to Endoplasmic reticulum under Sterol regulatory element-binding protein, and may sometimes address concerns connected to Membrane protein and Transport protein. His work carried out in the field of Cholesterol brings together such families of science as Macrophage and Reductase, Coenzyme A.
His primary areas of investigation include Biochemistry, LDL receptor, Cholesterol, Internal medicine and Endocrinology. His research combines Molecular biology and Biochemistry. His Molecular biology course of study focuses on Amino acid and Serine.
His LDL receptor research is multidisciplinary, relying on both Receptor, Cell surface receptor, Familial hypercholesterolemia and Low-density lipoprotein. His study in Low-density lipoprotein is interdisciplinary in nature, drawing from both Endocytosis and Low-density lipoprotein receptor gene family. As a member of one scientific family, Michael S. Brown mostly works in the field of Cholesterol, focusing on HMG-CoA reductase and, on occasion, 7-Dehydrocholesterol reductase and Coenzyme A.
Michael S. Brown focuses on Biochemistry, Cholesterol, Endocrinology, Internal medicine and Endoplasmic reticulum. His Biochemistry study is mostly concerned with Sterol, Sterol regulatory element-binding protein, Cholesterol 7 alpha-hydroxylase, Membrane and Chinese hamster ovary cell. His Sterol study combines topics from a wide range of disciplines, such as Transcription factor and HMG-CoA reductase.
His Cholesterol research includes elements of Cell biology, Binding site and NPC1. His work on Adipose tissue, Receptor, Fatty liver and LDL receptor as part of general Internal medicine study is frequently linked to Bottle, therefore connecting diverse disciplines of science. His research in Endoplasmic reticulum focuses on subjects like Membrane protein, which are connected to Transport protein and Transmembrane domain.
His main research concerns Cholesterol, Biochemistry, Endocrinology, Internal medicine and Sterol regulatory element-binding protein. His work on Sterol, Lipoprotein and Cholesterol 7 alpha-hydroxylase as part of general Cholesterol study is frequently connected to Extramural, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research ties Receptor and Endocrinology together.
He combines topics linked to Signal transduction with his work on Internal medicine. His Sterol regulatory element-binding protein research incorporates themes from Golgi apparatus, Endoplasmic reticulum and Membrane. The various areas that Michael S. Brown examines in his LDL receptor study include Familial hypercholesterolemia, Receptor recycling and Receptor-mediated endocytosis.
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A receptor-mediated pathway for cholesterol homeostasis.
Michael S. Brown;Joseph L. Goldstein.
Regulation of the mevalonate pathway.
Joseph L. Goldstein;Michael S. Brown.
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Jay D. Horton;Joseph L. Goldstein;Michael S. Brown.
Journal of Clinical Investigation (2002)
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
Michael S Brown;Joseph L Goldstein.
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown.
Proceedings of the National Academy of Sciences of the United States of America (1979)
Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
Michael S. Brown;Joseph L. Goldstein.
Annual Review of Biochemistry (1983)
Coated pits, coated vesicles, and receptor-mediated endocytosis
Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown.
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov.
Genes & Development (2000)
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
Joseph L. Goldstein;Sandip K. Basu;Michael S. Brown.
Methods in Enzymology (1983)
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
Tokuo Yamamoto;C. Geoffrey Davis;Michael S. Brown;Wolfgang J. Schneider.
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