H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 195 Citations 149,009 342 World Ranking 14 National Ranking 11

Research.com Recognitions

Awards & Achievements

2003 - Albany Medical Center Prize in Medicine and Biomedical Research

1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.

1990 - Fellow of the American Association for the Advancement of Science (AAAS)

1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan at a White House Ceremony on July 15, 1988. Awarded jointly with Dr. Joseph L. Goldstein, University of Texas Southwestern Medical Center.

1987 - Member of the National Academy of Medicine (NAM)

1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism

1985 - William Allan Award, the American Society of Human Genetics

1984 - Louisa Gross Horwitz Prize, Columbia University

1981 - Canada Gairdner International Award

1981 - Fellow of the American Academy of Arts and Sciences

1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

Michael S. Brown mainly focuses on Biochemistry, Endocrinology, Internal medicine, Sterol regulatory element-binding protein and Cholesterol. LDL receptor, Sterol, Low-density lipoprotein, HMG-CoA reductase and Binding site are among the areas of Biochemistry where the researcher is concentrating his efforts. He interconnects Receptor, Endocytosis and Familial hypercholesterolemia in the investigation of issues within LDL receptor.

Michael S. Brown mostly deals with Adipose tissue in his studies of Internal medicine. Within one scientific family, Michael S. Brown focuses on topics pertaining to Endoplasmic reticulum under Sterol regulatory element-binding protein, and may sometimes address concerns connected to Membrane protein and Transport protein. His work carried out in the field of Cholesterol brings together such families of science as Macrophage and Reductase, Coenzyme A.

His most cited work include:

  • A receptor-mediated pathway for cholesterol homeostasis. (4752 citations)
  • Regulation of the mevalonate pathway. (4483 citations)
  • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (3525 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, LDL receptor, Cholesterol, Internal medicine and Endocrinology. His research combines Molecular biology and Biochemistry. His Molecular biology course of study focuses on Amino acid and Serine.

His LDL receptor research is multidisciplinary, relying on both Receptor, Cell surface receptor, Familial hypercholesterolemia and Low-density lipoprotein. His study in Low-density lipoprotein is interdisciplinary in nature, drawing from both Endocytosis and Low-density lipoprotein receptor gene family. As a member of one scientific family, Michael S. Brown mostly works in the field of Cholesterol, focusing on HMG-CoA reductase and, on occasion, 7-Dehydrocholesterol reductase and Coenzyme A.

He most often published in these fields:

  • Biochemistry (51.33%)
  • LDL receptor (25.11%)
  • Cholesterol (24.44%)

What were the highlights of his more recent work (between 2005-2020)?

  • Biochemistry (51.33%)
  • Cholesterol (24.44%)
  • Endocrinology (22.22%)

In recent papers he was focusing on the following fields of study:

Michael S. Brown focuses on Biochemistry, Cholesterol, Endocrinology, Internal medicine and Endoplasmic reticulum. His Biochemistry study is mostly concerned with Sterol, Sterol regulatory element-binding protein, Cholesterol 7 alpha-hydroxylase, Membrane and Chinese hamster ovary cell. His Sterol study combines topics from a wide range of disciplines, such as Transcription factor and HMG-CoA reductase.

His Cholesterol research includes elements of Cell biology, Binding site and NPC1. His work on Adipose tissue, Receptor, Fatty liver and LDL receptor as part of general Internal medicine study is frequently linked to Bottle, therefore connecting diverse disciplines of science. His research in Endoplasmic reticulum focuses on subjects like Membrane protein, which are connected to Transport protein and Transmembrane domain.

Between 2005 and 2020, his most popular works were:

  • Protein Sensors for Membrane Sterols (1216 citations)
  • Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1 (1147 citations)
  • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (921 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His main research concerns Cholesterol, Biochemistry, Endocrinology, Internal medicine and Sterol regulatory element-binding protein. His work on Sterol, Lipoprotein and Cholesterol 7 alpha-hydroxylase as part of general Cholesterol study is frequently connected to Extramural, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research ties Receptor and Endocrinology together.

He combines topics linked to Signal transduction with his work on Internal medicine. His Sterol regulatory element-binding protein research incorporates themes from Golgi apparatus, Endoplasmic reticulum and Membrane. The various areas that Michael S. Brown examines in his LDL receptor study include Familial hypercholesterolemia, Receptor recycling and Receptor-mediated endocytosis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

A receptor-mediated pathway for cholesterol homeostasis.

Michael S. Brown;Joseph L. Goldstein.
Science (1986)

7345 Citations

Regulation of the mevalonate pathway.

Joseph L. Goldstein;Michael S. Brown.
Nature (1990)

6888 Citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton;Joseph L. Goldstein;Michael S. Brown.
Journal of Clinical Investigation (2002)

5828 Citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

Michael S Brown;Joseph L Goldstein.
Cell (1997)

4768 Citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown.
Proceedings of the National Academy of Sciences of the United States of America (1979)

3249 Citations

Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis

Michael S. Brown;Joseph L. Goldstein.
Annual Review of Biochemistry (1983)

3063 Citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown.
Nature (1979)

2658 Citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov.
Genes & Development (2000)

2229 Citations

Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Joseph L. Goldstein;Sandip K. Basu;Michael S. Brown.
Methods in Enzymology (1983)

2055 Citations

Protein Sensors for Membrane Sterols

Joseph L. Goldstein;Russell A. DeBose-Boyd;Michael S. Brown.
Cell (2006)

1872 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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