Michael S. Brown

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United States Leader Award
• 2025 - Research.com Best Scientists Award
• 2025 - Research.com Biology and Biochemistry in United States Leader Award
• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2003 - Albany Medical Center Prize in Medicine and Biomedical Research
• 1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.
• 1990 - Fellow of the American Association for the Advancement of Science (AAAS)
• 1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan at a White House Ceremony on July 15, 1988. Awarded jointly with Dr. Joseph L. Goldstein, University of Texas Southwestern Medical Center.
• 1987 - Member of the National Academy of Medicine (NAM)
• 1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
• 1985 - William Allan Award, the American Society of Human Genetics
• 1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism
• 1984 - Louisa Gross Horwitz Prize, Columbia University
• 1981 - Fellow of the American Academy of Arts and Sciences
• 1981 - Canada Gairdner International Award
• 1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians

Overview

Best Publications

• Regulation of the mevalonate pathway.

  Joseph L. Goldstein;Michael S. Brown

  11247
  Citations

• A receptor-mediated pathway for cholesterol homeostasis.

  Michael S. Brown;Joseph L. Goldstein

  10048
  Citations

• SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

  Jay D. Horton;Joseph L. Goldstein;Michael S. Brown

  5448
  Citations

• The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

  Michael S Brown;Joseph L Goldstein

  5320
  Citations

• Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis

  Michael S. Brown;Joseph L. Goldstein

  3621
  Citations

• Binding Site on Macrophages that Mediates Uptake and Degradation of Acetylated Low Density Lipoprotein, Producing Massive Cholesterol Deposition

  Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown

  3509
  Citations

• Knowledge-based analysis of microarray gene expression data by using support vector machines

  Michael P. S. Brown;William Noble Grundy;David Lin;Nello Cristianini

  3277
  Citations

• Coated pits, coated vesicles, and receptor-mediated endocytosis

  Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown

  2956
  Citations

• HIDDEN MARKOV MODELS IN COMPUTATIONAL BIOLOGY: APPLICATIONS TO PROTEIN MODELING

  Anders Krogh;Michael Brown;I. S Mian;Kimmen Sjolander

  2811
  Citations

• Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

  Joseph L. Goldstein;Sandip K. Basu;Michael S. Brown

  2356
  Citations

• Protein Sensors for Membrane Sterols

  Joseph L. Goldstein;Russell A. DeBose-Boyd;Michael S. Brown

  2293
  Citations

• Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

  Joseph L. Goldstein;Michael S. Brown;Richard G. W. Anderson;David W. Russell

  2245
  Citations

• ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

  Jin Ye;Robert B Rawson;Ryutaro Komuro;Xi Chen

  2142
  Citations

• Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

  Joseph L. Goldstein;Michael S. Brown

  2071
  Citations

• Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

  Shun Ishibashi;Michael S Brown;Joseph L Goldstein;Robert D. Gerard

  2005
  Citations

• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

  Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov

  2000
  Citations

• The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

  Tokuo Yamamoto;C. Geoffrey Davis;Michael S. Brown;Wolfgang J. Schneider

  1974
  Citations

• A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

  Michael S. Brown;Joseph L. Goldstein

  1954
  Citations

• Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

  David A. Guertin;David A. Guertin;Deanna M. Stevens;Carson C. Thoreen;Aurora A. Burds

  1782
  Citations

• Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

  Michael S. Brown;Joseph L. Goldstein

  1670
  Citations