World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
64
Citations
15340
World Ranking
8009
National Ranking
2324

Biology and Biochemistry

D-Index
69
Citations
16931
World Ranking
7393
National Ranking
3378

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ta-Yuan Chang is affiliated with Dartmouth College in the United States and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Surgery, Molecular Biology, Physiology, Oncology, and Neurology.

The main research topics explored by Ta-Yuan Chang include:

  • Cholesterol and Lipid Metabolism
  • Peroxisome Proliferator-Activated Receptors
  • Lipoproteins and Cardiovascular Health
  • Drug Transport and Resistance Mechanisms
  • Lipid Membrane Structure and Behavior
  • RNA and protein synthesis mechanisms
  • Receptor Mechanisms and Signaling

They have published extensively with frequent appearances in several journals and preprint servers. The most frequent publication venues include:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Frontiers in Aging Neuroscience
  • Nature Communications

Their recent published papers cover topics related to cholesterol metabolism, inhibition mechanisms, and neurodegenerative disease research. Selected titles with publication years and venues are:

  • Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy, 2021, Frontiers in Aging Neuroscience
  • Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor, 2020, Nature Communications
  • Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity, 2023, International Journal of Molecular Sciences
  • Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells, 2022, Proceedings of the National Academy of Sciences
  • Blocking cholesterol storage to treat Alzheimer's disease, 2021, Exploration of Neuroprotective Therapy

Ta-Yuan Chang has collaborated extensively with other researchers. Frequent coauthors include:

  • Catherine C.Y. Chang
  • Thao N. Huynh
  • Adrianna L. De La Torre
  • Matthew C. Havrda
  • Dylan B. Ness

In recognition of contributions to science, Ta-Yuan Chang was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

    Eugene D. Carstea;Jill A. Morris;Katherine G. Coleman;Stacie K. Loftus

  • Potentiating the antitumour response of CD8 + T cells by modulating cholesterol metabolism

    Wei Yang;Yibing Bai;Ying Xiong;Jin Zhang

  • Cholesterol Sensing, Trafficking, and Esterification

    Ta-Yuan Chang;Catherine C Y Chang;Nobutaka Ohgami;Yoshio Yamauchi

  • ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

    T. Y. Chang;Catherine C. Y. Chang;Dong Cheng

  • Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

    Luigi Puglielli;Genevieve Konopka;Eunju Pack-Chung;Laura A. MacKenzie Ingano

  • Complementation Cloning of S2P, a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

    Robert B. Rawson;Nikolai G. Zelenski;Deepak Nijhawan;Jin Ye

  • Acyl-coenzyme A:cholesterol acyltransferases.

    Ta-Yuan Chang;Bo-Liang Li;Catherine C. Y. Chang;Yasuomi Urano

  • Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

    Catherine C Y Chang;Ho Young Huh;Kenneth M. Cadigan;Ta Yuan Chang

  • Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.

    Ta-Yuan Chang;Catherine C.Y. Chang;Song Lin;Chunjiang Yu

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine

    Catherine C.Y. Chang;Naomi Sakashita;Kim Ornvold;Oneil Lee

  • Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

    Nobutaka Ohgami;Dennis C. Ko;Matthew Thomas;Matthew P. Scott

  • Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells.

    T Y Chang;J S Limanek

  • ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

    Elena Y. Bryleva;Maximillian A. Rogers;Catherine C.Y. Chang;Floyd Buen

  • Role of Niemann-Pick Type C1 Protein in Intracellular Trafficking of Low Density Lipoprotein-derived Cholesterol *

    Jonathan C. Cruz;Shigeki Sugii;Chunjiang Yu;Ta-Yuan Chang

  • Activation of Acyl-Coenzyme A:Cholesterol Acyltransferase by Cholesterol or by Oxysterol in a Cell-free System

    Dong Cheng;Catherine C.Y. Chang;Xian-ming Qu;Ta-Yuan Chang

  • Niemann-Pick Type C Disease and Intracellular Cholesterol Trafficking

    Ta-Yuan Chang;Patrick C. Reid;Shigeki Sugii;Nobutaka Ohgami

  • Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells

    Tsuneo Yamazaki;Ta-Yuan Chang;Christian Haass;Yasuo Ihara

  • Expression of ACAT-1 Protein in Human Atherosclerotic Lesions and Cultured Human Monocytes-Macrophages

    Akira Miyazaki;Naomi Sakashita;Oneil Lee;Kiyoshi Takahashi

  • Tissue-specific Expression and Cholesterol Regulation of Acylcoenzyme A:Cholesterol Acyltransferase (ACAT) in Mice: MOLECULAR CLONING OF MOUSE ACAT cDNA, CHROMOSOMAL LOCALIZATION, AND REGULATION OF ACAT IN VIVO AND IN VITRO

    Patricia J. Uelmen;Kazuhiro Oka;Merry Sullivan;Catherine C.Y. Chang

Frequent Co-Authors

Catherine C. Y. Chang
Catherine C. Y. Chang Dartmouth College
Bao-Liang Song
Bao-Liang Song Wuhan University
Akira Miyazaki
Akira Miyazaki Showa University
Seikoh Horiuchi
Seikoh Horiuchi Kumamoto University
Li Yang
Li Yang Chinese Academy of Sciences
Motohiro Takeya
Motohiro Takeya Kumamoto Health Science University
Kiyoshi Takahashi
Kiyoshi Takahashi Kumamoto University
Shinji Yokoyama
Shinji Yokoyama Chubu University
William F. Hickey
William F. Hickey Dartmouth College
Mary Ellen Jones
Mary Ellen Jones University of North Carolina at Chapel Hill

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