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Biology and Biochemistry

D-Index
48
Citations
10181
World Ranking
18296
National Ranking
7472

Overview

Stephen L. Sturley is affiliated with Columbia University Medical Center in the United States and specializes in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, including Cell Biology, Molecular Biology, Physiology, Genetics, and Immunology.

Their research has contributed to multiple topics such as Cellular transport and secretion, Virus-based gene therapy research, Phagocytosis and Immune Regulation, COVID-19 Clinical Research Studies, Lysosomal Storage Disorders Research, Calcium signaling and nucleotide metabolism, and Single-cell and spatial transcriptomics.

Recent publications by Stephen L. Sturley include the following papers:

  • Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity (2020, Journal of Lipid Research)

Other papers featuring Sturley as a co-author with colleagues include:

  • Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential (2023, Genetics)
  • Ordinary differential equations to construct invertible generative models of cell type and tissue-specific regulatory networks (2023, bioRxiv (Cold Spring Harbor Laboratory))
  • Arv1; a "Mover and Shaker" of Subcellular Lipids (2025, Contact)

Frequent collaborators in their research include Andrew B. Munkacsi, Natalie Hammond, Tamayanthi Rajakumar, Katsumi Higaki, and Zsuzsa Márka. The frequent publication venues where their work appears include Journal of Lipid Research, Genetics, bioRxiv (Cold Spring Harbor Laboratory), and Contact.

Best Publications

  • Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

    Eugene D. Carstea;Jill A. Morris;Katherine G. Coleman;Stacie K. Loftus

  • Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

    Estela Area-Gomez;Maria del Carmen Lara Castillo;Marc D Tambini;Cristina Guardia-Laguarta

  • Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes

    Peter Oelkers;Ajay Behari;Debra Cromley;Jeffrey T. Billheimer

  • Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.

    Tilla S. Worgall;Tilla S. Worgall;Stephen L. Sturley;Toru Seo;Toru Seo;Timothy F. Osborne

  • The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast

    Peter Oelkers;Debra Cromley;Mahajabeen Padamsee;Jeffrey T. Billheimer

  • Transcriptional Profiling Identifies Two Members of the ATP-binding Cassette Transporter Superfamily Required for Sterol Uptake in Yeast

    Lisa J. Wilcox;Dina A. Balderes;Brook Wharton;Arthur H. Tinkelenberg

  • Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase

    Pierrette Bouvier-Navé;Pierre Benveniste;Peter Oelkers;Stephen L. Sturley

  • Sterol Esterification in Yeast: A Two-Gene Process

    Hongyuan Yang;Martin Bard;Debora A. Bruner;Anne Gleeson

  • HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia.

    Jun-Shan Liang;Oliver Distler;Oliver Distler;David A. Cooper;Haris Jamil

  • A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.

    Peter Oelkers;Arthur Tinkelenberg;Naz Erdeniz;Debra Cromley

  • The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds

    Martha C.A. Laboissière;Stephen L. Sturley;Ronald T. Raines

  • The pathophysiology and mechanisms of NP-C disease.

    Stephen L. Sturley;Marc C. Patterson;William Balch;Laura Liscum

  • Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death

    Jeanne Garbarino;Mahajabeen Padamsee;Lisa Wilcox;Peter M. Oelkers

  • Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C–related protein reveals a primordial role in subcellular sphingolipid distribution

    Krishnamurthy Malathi;Katsumi Higaki;Arthur H. Tinkelenberg;Dina A. Balderes

  • Saturated with fat: new perspectives on lipotoxicity.

    Jeanne Garbarino;Stephen L Sturley

  • Phosphatidate Phosphatase Activity Plays Key Role in Protection against Fatty Acid-induced Toxicity in Yeast

    Stylianos Fakas;Yixuan Qiu;Joseph L. Dixon;Gil-Soo Han

  • Overexpression of Human Diacylglycerol Acyltransferase 1, Acyl-CoA:Cholesterol Acyltransferase 1, or Acyl-CoA:Cholesterol Acyltransferase 2 Stimulates Secretion of Apolipoprotein B-containing Lipoproteins in McA-RH7777 Cells

    John J. Liang;Peter Oelkers;Cuiying Guo;Pi-Chun Chu

  • Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport

    Laura Liscum;Stephen L. Sturley

  • Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.

    Aaron R. Turkish;Annette L. Henneberry;Debra Cromley;Mahajabeen Padamsee

  • A Molecular Target for Viral Killer Toxin: TOK1 Potassium Channels

    Aamir Ahmed;Federico Sesti;Nitza Ilan;Theodore M Shih

Frequent Co-Authors

Alan D. Attie
Alan D. Attie University of Wisconsin–Madison
Jeffrey T. Billheimer
Jeffrey T. Billheimer University of Pennsylvania
Richard J. Deckelbaum
Richard J. Deckelbaum Columbia University
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Martin Bard
Martin Bard Indiana University – Purdue University Indianapolis
Hongyuan Yang
Hongyuan Yang University of New South Wales
Henry N. Ginsberg
Henry N. Ginsberg Columbia University
David A. Cooper
David A. Cooper University of New South Wales
Peter G. Pentchev
Peter G. Pentchev National Institutes of Health
Michael R. Culbertson
Michael R. Culbertson University of Wisconsin–Madison

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