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Biology and Biochemistry

D-Index
61
Citations
13314
World Ranking
11353
National Ranking
305

Overview

Tony Tiganis is affiliated with the Peter MacCallum Cancer Centre in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. The scientist's work encompasses several subfields including Molecular Biology, Immunology, Oncology, Epidemiology, and Physiology.

The research topics covered by Tony Tiganis include:

  • Protein Tyrosine Phosphatases
  • Galectins and Cancer Biology
  • Adipose Tissue and Metabolism
  • T-cell and B-cell Immunology
  • Liver Disease Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction

Frequent publication venues for their work include:

  • FEBS Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Nature Communications
  • Journal of Clinical Investigation

Some of the recent papers authored or co-authored by Tony Tiganis are:

  • "PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity" (2021), Cancer Discovery
  • "Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance" (2021), Science Advances
  • "A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity" (2023), Nature Communications
  • "PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells" (2020), Cell Reports
  • "Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy" (2023), Angewandte Chemie International Edition

Frequent co-authors who have collaborated with Tony Tiganis include:

  • Florian Wiede
  • Chrysovalantou E. Xirouchaki
  • Séamus J. Martin
  • Dublin Chair
  • Andrey Abramov

Best Publications

  • Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

    Andrew J. Flint;Tony Tiganis;David Barford;Nicholas K. Tonks

  • Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

    Belinda J. Michell;Zhi-ping Chen;Tony Tiganis;David Stapleton

  • Reactive oxygen species enhance insulin sensitivity.

    Kim Yong Loh;Haiyang Deng;Atsushi Fukushima;Xiaochu Cai

  • The Akt kinase signals directly to endothelial nitric oxide synthase.

    B.J. Michell;J.E. Griffiths;K.I. Mitchelhill;I. Rodriguez-Crespo

  • Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

    Garron T Dodd;Stephanie Sylvie Decherf;Kim Y Loh;Stephanie E Simonds

  • Protein tyrosine phosphatase function: the substrate perspective

    Tony Tiganis;Anton M. Bennett

  • Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B

    Tzu-Ching Meng;Deirdre A. Buckley;Sandra Galic;Tony Tiganis

  • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

    Clare G Fedele;Lisa M Ooms;Miriel Ho;Jessica L Vieusseux

  • Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

    Marcus Grohmann;Florian Wiede;Garron Gt Dodd;Esteban Nicolas Gurzov

  • Epidermal Growth Factor Promotes MDA-MB-231 Breast Cancer Cell Migration through a Phosphatidylinositol 3′-Kinase and Phospholipase C-dependent Mechanism

    John T. Price;Tony Tiganis;Anurag Agarwal;Daniel Djakiew

  • Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase

    Tony Tiganis;Anton M. Bennett;Kodimangalam S. Ravichandran;Nicholas K. Tonks

  • Reactive oxygen species and insulin resistance: the good, the bad and the ugly

    Tony Tiganis

  • Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

    Kylie M. Quinn;Annette Fox;Kim L. Harland;Brendan E. Russ

  • Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

    Sandra Galic;Christine Hauser;Barbara B. Kahn;Fawaz G. Haj

  • T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

    Florian Wiede;Benjamin J. Shields;Sock Hui Chew;Konstantinos Kyparissoudis

  • Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP

    Sandra Galic;Manuela Klingler-Hoffmann;Michelle Teena Fodero-Tavoletti;Michelle A Puryer

  • PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis

    Tony Tiganis

  • Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

    Kim Loh;Atsushi Fukushima;Xinmei Mary Zhang;Sandra Galic

  • Selective regulation of tumor necrosis factor–induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

    Catherine Julia van Vliet;Patricia Evelina Bukczynska;Michelle A Puryer;Christine Marie Sadek

  • Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase | NOVA. The University of Newcastle's Digital Repository

    Belinda J. Michell;Zhi-ping Chen;Tony Tiganis;David Stapleton

Frequent Co-Authors

Michael A. Cowley
Michael A. Cowley Monash University
Zhong Yin Zhang
Zhong Yin Zhang Purdue University West Lafayette
Bruce E. Kemp
Bruce E. Kemp Australian Catholic University
Zane B. Andrews
Zane B. Andrews Monash University
Christina Anne Mitchell
Christina Anne Mitchell Monash University
Matthew J. Watt
Matthew J. Watt University of Melbourne
Nicholas K. Tonks
Nicholas K. Tonks Cold Spring Harbor Laboratory
Jamie Rossjohn
Jamie Rossjohn Monash University
Dale I. Godfrey
Dale I. Godfrey University of Melbourne
Benjamin G. Neel
Benjamin G. Neel New York University Langone Medical Center

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